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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14976

FusionGeneSummary for GNL3L_XAGE3

check button Fusion gene summary
Fusion gene informationFusion gene name: GNL3L_XAGE3
Fusion gene ID: 14976
HgeneTgene
Gene symbol

GNL3L

XAGE3

Gene ID

54552

170626

Gene nameG protein nucleolar 3 likeX antigen family member 3
SynonymsGNL3BCT12.3a|CT12.3b|GAGED4|PLAC6|XAGE-3|pp9012
Cytomap

Xp11.22

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein-like 3-like proteinG protein nucleolar 3Bguanine nucleotide binding protein-like 3 (nucleolar)-likenovel GTPaseX antigen family member 3CT12.3G antigen, family D, 4cancer/testis antigen 12.3cancer/testis antigen family 12, member 3acancer/testis antigen family 12, member 3bg antigen family D member 4placenta-specific 6placenta-specific gene 6 proteinprote
Modification date2018052320180519
UniProtAcc

Q9NVN8

Q8WTP9

Ensembl transtripts involved in fusion geneENST00000336470, ENST00000360845, 
ENST00000489691, 
ENST00000375491, 
ENST00000346279, 
Fusion gene scores* DoF score4 X 5 X 4=801 X 1 X 1=1
# samples 61
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: GNL3L [Title/Abstract] AND XAGE3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGNL3L

GO:0031647

regulation of protein stability

19487455

HgeneGNL3L

GO:0032091

negative regulation of protein binding

19487455

HgeneGNL3L

GO:1904816

positive regulation of protein localization to chromosome, telomeric region

19487455


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-ZJ-A8QR-01AGNL3LchrX

54556852

+XAGE3chrX

52896172

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000336470ENST00000375491GNL3LchrX

54556852

+XAGE3chrX

52896172

-
intron-5UTRENST00000336470ENST00000346279GNL3LchrX

54556852

+XAGE3chrX

52896172

-
5UTR-5UTRENST00000360845ENST00000375491GNL3LchrX

54556852

+XAGE3chrX

52896172

-
5UTR-5UTRENST00000360845ENST00000346279GNL3LchrX

54556852

+XAGE3chrX

52896172

-
3UTR-5UTRENST00000489691ENST00000375491GNL3LchrX

54556852

+XAGE3chrX

52896172

-
3UTR-5UTRENST00000489691ENST00000346279GNL3LchrX

54556852

+XAGE3chrX

52896172

-

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FusionProtFeatures for GNL3L_XAGE3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNL3L

Q9NVN8

XAGE3

Q8WTP9

Stabilizes TERF1 telomeric association by preventingTERF1 recruitment by PML. Stabilizes TERF1 protein by preventingits ubiquitination and hence proteasomal degradation. Does so byinterfering with TERF1-binding to FBXO4 E3 ubiquitin-proteinligase. Required for cell proliferation. By stabilizing TRF1protein during mitosis, promotes metaphase-to-anaphase transition.Stabilizes MDM2 protein by preventing its ubiquitination, andhence proteasomal degradation. By acting on MDM2, may affect TP53activity. Required for normal processing of ribosomal pre-rRNA.Binds GTP. {ECO:0000269|PubMed:16251348,ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455,ECO:0000269|PubMed:21132010}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNL3L_XAGE3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNL3L_XAGE3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNL3LLDOC1, MDM2, TP53, TERF1, TERT, ELAVL1, SLC2A4, ADRB2, ALAS1, ROPN1, LZTS2, BRCA1, BSG, NT5E, PRSS50, TGOLN2, OLFM4, FTSJ3, GTPBP4, SRP72, NMD3, NOP58, OLA1, PES1, KRAS, HIST1H2BG, HNRNPU, RPL10, SMC3, FTSJ1, EXOSC5, CD70, ERP44, APLNR, LAMP2, PROZ, BBS7, TOR1AIP2, FAM174A, TRIM25XAGE3HTT, GMCL1, ZNF644, METAP1D, WIZ, EHMT2, EHMT1, GAST, RSPRY1, GTSE1, DEFA5, RNPEPL1, PSMG2, CROCCP2, PSMG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNL3L_XAGE3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNL3L_XAGE3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource