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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14975

FusionGeneSummary for GNL3L_PAGE5

check button Fusion gene summary
Fusion gene informationFusion gene name: GNL3L_PAGE5
Fusion gene ID: 14975
HgeneTgene
Gene symbol

GNL3L

PAGE5

Gene ID

54552

90737

Gene nameG protein nucleolar 3 likePAGE family member 5
SynonymsGNL3BCT16|CT16.1|CT16.2|GAGEE1|PAGE-5
Cytomap

Xp11.22

Xp11.21

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein-like 3-like proteinG protein nucleolar 3Bguanine nucleotide binding protein-like 3 (nucleolar)-likenovel GTPaseP antigen family member 5P antigen family, member 5 (prostate associated)cancer/testis antigen 16.1cancer/testis antigen family 16, member 1cancer/testis antigen family 16, member 2g antigen family E member 1prostate-associated gene 5 protein
Modification date2018052320180519
UniProtAcc

Q9NVN8

Q96GU1

Ensembl transtripts involved in fusion geneENST00000336470, ENST00000360845, 
ENST00000489691, 
ENST00000289619, 
ENST00000374955, ENST00000374952, 
Fusion gene scores* DoF score4 X 5 X 4=801 X 1 X 1=1
# samples 61
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: GNL3L [Title/Abstract] AND PAGE5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGNL3L

GO:0031647

regulation of protein stability

19487455

HgeneGNL3L

GO:0032091

negative regulation of protein binding

19487455

HgeneGNL3L

GO:1904816

positive regulation of protein localization to chromosome, telomeric region

19487455


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5KV-01AGNL3LchrX

54559018

+PAGE5chrX

55247808

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336470ENST00000289619GNL3LchrX

54559018

+PAGE5chrX

55247808

+
5CDS-5UTRENST00000336470ENST00000374955GNL3LchrX

54559018

+PAGE5chrX

55247808

+
5CDS-5UTRENST00000336470ENST00000374952GNL3LchrX

54559018

+PAGE5chrX

55247808

+
In-frameENST00000360845ENST00000289619GNL3LchrX

54559018

+PAGE5chrX

55247808

+
5CDS-5UTRENST00000360845ENST00000374955GNL3LchrX

54559018

+PAGE5chrX

55247808

+
5CDS-5UTRENST00000360845ENST00000374952GNL3LchrX

54559018

+PAGE5chrX

55247808

+
3UTR-3CDSENST00000489691ENST00000289619GNL3LchrX

54559018

+PAGE5chrX

55247808

+
3UTR-5UTRENST00000489691ENST00000374955GNL3LchrX

54559018

+PAGE5chrX

55247808

+
3UTR-5UTRENST00000489691ENST00000374952GNL3LchrX

54559018

+PAGE5chrX

55247808

+

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FusionProtFeatures for GNL3L_PAGE5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNL3L

Q9NVN8

PAGE5

Q96GU1

Stabilizes TERF1 telomeric association by preventingTERF1 recruitment by PML. Stabilizes TERF1 protein by preventingits ubiquitination and hence proteasomal degradation. Does so byinterfering with TERF1-binding to FBXO4 E3 ubiquitin-proteinligase. Required for cell proliferation. By stabilizing TRF1protein during mitosis, promotes metaphase-to-anaphase transition.Stabilizes MDM2 protein by preventing its ubiquitination, andhence proteasomal degradation. By acting on MDM2, may affect TP53activity. Required for normal processing of ribosomal pre-rRNA.Binds GTP. {ECO:0000269|PubMed:16251348,ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455,ECO:0000269|PubMed:21132010}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+21658_886583Coiled coilOntology_term=ECO:0000255
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+21658_886583Coiled coilOntology_term=ECO:0000255
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+216125_3106583DomainCP-type G
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+216125_3106583DomainCP-type G
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+216173_1766583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+216259_2666583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+216303_3066583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+216173_1766583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+216259_2666583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+216303_3066583Nucleotide bindingGTP
HgeneGNL3LchrX:54559018chrX:55247808ENST00000336470+2169_356583RegionNote=Required for nucleolar localization
HgeneGNL3LchrX:54559018chrX:55247808ENST00000360845+2169_356583RegionNote=Required for nucleolar localization


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FusionGeneSequence for GNL3L_PAGE5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GNL3L_ENST00000336470_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_120aa
MMKLRHMRDMSEHVTRSQSSERGNDQESSQPVGPVIVQQPTEEKRQEEEPPTDNQGIAPSGEIKNEGAPAVQGTDVEAFQQELALLKIED

>In-frame_GNL3L_ENST00000360845_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_120aa
MMKLRHMRDMSEHVTRSQSSERGNDQESSQPVGPVIVQQPTEEKRQEEEPPTDNQGIAPSGEIKNEGAPAVQGTDVEAFQQELALLKIED


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GNL3L_ENST00000336470_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_360nt
ATGATGAAACTTAGACACATGAGAGATATGAGTGAGCATGTAACAAGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAG
CCAGTTGGACCTGTGATTGTCCAGCAGCCCACTGAGGAAAAACGTCAAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGT
GGGGAGATCAAAAATGAAGGAGCACCTGCTGTTCAAGGGACTGATGTGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGAT
GCACCTGGAGATGGTCCTGATGTCAGGGAGGGGACTCTGCCCACTTTTGATCCCACTAAAGTGCTGGAAGCAGGTGAAGGGCAACTATAG

>In-frame_GNL3L_ENST00000360845_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_360nt
ATGATGAAACTTAGACACATGAGAGATATGAGTGAGCATGTAACAAGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAG
CCAGTTGGACCTGTGATTGTCCAGCAGCCCACTGAGGAAAAACGTCAAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGT
GGGGAGATCAAAAATGAAGGAGCACCTGCTGTTCAAGGGACTGATGTGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGAT
GCACCTGGAGATGGTCCTGATGTCAGGGAGGGGACTCTGCCCACTTTTGATCCCACTAAAGTGCTGGAAGCAGGTGAAGGGCAACTATAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_GNL3L_ENST00000336470_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_602nt
GATCCGGAAGTCGGAGCCTAGCTGCGCGAGAGTTTCTGCTCGCTCAACCGAGTTGTCGTGTTGCCCTCGCTTCTCAGATCCCCGCCGGAA
GTGAAGAGAGCAAGCAGATTTGAACCTATCTGCTTTCAAGCTGGTCATCATGATGAAACTTAGACACATGAGAGATATGAGTGAGCATGT
AACAAGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAGCCAGTTGGACCTGTGATTGTCCAGCAGCCCACTGAGGAAAA
ACGTCAAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGTGGGGAGATCAAAAATGAAGGAGCACCTGCTGTTCAAGGGAC
TGATGTGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGCACCTGGAGATGGTCCTGATGTCAGGGAGGGGACTCTGCC
CACTTTTGATCCCACTAAAGTGCTGGAAGCAGGTGAAGGGCAACTATAGGTTTAAACCAAGACAAATGAAGACTGAAACCAAGAATATTG

>In-frame_GNL3L_ENST00000360845_chrX_54559018_+_PAGE5_ENST00000289619_chrX_55247808_+_688nt
GTTTCTGCTCGCTCAACCGAGTTGTCGTGTTGCCCTCGCTTCTCAGATCCCCGCCGGAAGTGTAAGTAAGAAACTTCTCTCCTCTTTTCT
CACAATGTGCGCTCACCTAGACGGCCGGGCAGTTAGGATCGTCTATTGGATGTGAAACCAGAGATGCCCGCCAACCTGGAATAGAGAGGA
AGAGAGCAAGCAGATTTGAACCTATCTGCTTTCAAGCTGGTCATCATGATGAAACTTAGACACATGAGAGATATGAGTGAGCATGTAACA
AGATCCCAATCCTCAGAAAGAGGAAATGACCAAGAGTCTTCCCAGCCAGTTGGACCTGTGATTGTCCAGCAGCCCACTGAGGAAAAACGT
CAAGAAGAGGAACCACCAACTGATAATCAGGGTATTGCACCTAGTGGGGAGATCAAAAATGAAGGAGCACCTGCTGTTCAAGGGACTGAT
GTGGAAGCTTTTCAACAGGAACTGGCTCTGCTTAAGATAGAGGATGCACCTGGAGATGGTCCTGATGTCAGGGAGGGGACTCTGCCCACT
TTTGATCCCACTAAAGTGCTGGAAGCAGGTGAAGGGCAACTATAGGTTTAAACCAAGACAAATGAAGACTGAAACCAAGAATATTGTTCT


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FusionGenePPI for GNL3L_PAGE5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNL3LLDOC1, MDM2, TP53, TERF1, TERT, ELAVL1, SLC2A4, ADRB2, ALAS1, ROPN1, LZTS2, BRCA1, BSG, NT5E, PRSS50, TGOLN2, OLFM4, FTSJ3, GTPBP4, SRP72, NMD3, NOP58, OLA1, PES1, KRAS, HIST1H2BG, HNRNPU, RPL10, SMC3, FTSJ1, EXOSC5, CD70, ERP44, APLNR, LAMP2, PROZ, BBS7, TOR1AIP2, FAM174A, TRIM25PAGE5POT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNL3L_PAGE5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNL3L_PAGE5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource