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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14969

FusionGeneSummary for GNL1_REPS1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNL1_REPS1
Fusion gene ID: 14969
HgeneTgene
Gene symbol

GNL1

REPS1

Gene ID

2794

85021

Gene nameG protein nucleolar 1 (putative)RALBP1 associated Eps domain containing 1
SynonymsHSR1NBIA7|RALBP1
Cytomap

6p21.33

6q24.1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein-like 1GTP-binding protein HSR1HSR1 GTP-binding proteinralBP1-associated Eps domain-containing protein 1ralBP1-interacting protein 1
Modification date2018051920180519
UniProtAcc

P36915

Q96D71

Ensembl transtripts involved in fusion geneENST00000376621, ENST00000383450, 
ENST00000441604, ENST00000550904, 
ENST00000428189, ENST00000551708, 
ENST00000437917, ENST00000548423, 
ENST00000383596, ENST00000550942, 
ENST00000454829, ENST00000552589, 
ENST00000417834, ENST00000551903, 
ENST00000450536, ENST00000367663, 
ENST00000409812, ENST00000258062, 
ENST00000415951, ENST00000531675, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 5 X 3=90
# samples 56
** MAII scorelog2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNL1 [Title/Abstract] AND REPS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGNL1

GO:0006974

cellular response to DNA damage stimulus

17525332


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3U5-01AGNL1chr6

30520244

-REPS1chr6

139242261

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000376621ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
Frame-shiftENST00000376621ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
Frame-shiftENST00000376621ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
Frame-shiftENST00000376621ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
Frame-shiftENST00000376621ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
5CDS-intronENST00000376621ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383450ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383450ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383450ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383450ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383450ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000383450ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000441604ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000441604ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000441604ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000441604ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000441604ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000441604ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550904ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550904ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550904ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550904ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550904ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000550904ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000428189ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000428189ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000428189ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000428189ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000428189ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000428189ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551708ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551708ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551708ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551708ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551708ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000551708ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000437917ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000437917ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000437917ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000437917ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000437917ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000437917ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000548423ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000548423ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000548423ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000548423ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000548423ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000548423ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383596ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383596ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383596ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383596ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000383596ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000383596ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550942ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550942ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550942ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550942ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000550942ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000550942ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000454829ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000454829ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000454829ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000454829ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000454829ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000454829ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000552589ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000552589ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000552589ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000552589ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000552589ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000552589ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000417834ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000417834ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000417834ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000417834ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000417834ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000417834ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551903ENST00000450536GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551903ENST00000367663GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551903ENST00000409812GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551903ENST00000258062GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-3CDSENST00000551903ENST00000415951GNL1chr6

30520244

-REPS1chr6

139242261

-
intron-intronENST00000551903ENST00000531675GNL1chr6

30520244

-REPS1chr6

139242261

-

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FusionProtFeatures for GNL1_REPS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNL1

P36915

REPS1

Q96D71

Possible regulatory or functional link with thehistocompatibility cluster.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNL1_REPS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNL1_REPS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GNL1RAD21, RPL5, RPS15A, GDI1, PTP4A1, ZNF212, ALDOC, ALYREF, DDX18, EIF5B, HNRNPC, HUWE1, KPNA3, KRR1, NOP58, PABPC4, PES1, RANGAP1, RPL7, RPLP0, NTRK1, TULP3, ABCF2, CCDC116, KLHL40, HINT1, DYNC1I2, C2orf44, PAPSS1, SLC2A12, FGBREPS1RALBP1, RAB11FIP2, ITSN2, SGIP1, ITSN1, AMPH, ABL1, AP2M1, CFTR, REPS1, WWC2, ATF4, PIN1, TRAPPC2L, SLC25A41, CCDC101, LIMS1, LRFN4, NTRK1, CLTC, GTSE1, AAK1, REPS2, AP2S1, PNMA1, BMP2K, CLINT1, HIP1R, RUNDC3A, LSR, PNMA2, STAMBPL1, STX11, AP2A2, AP2A1, TRIM11, MYO6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GNL1_REPS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNL1_REPS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource