FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14967

FusionGeneSummary for GNGT1_UBE2I

check button Fusion gene summary
Fusion gene informationFusion gene name: GNGT1_UBE2I
Fusion gene ID: 14967
HgeneTgene
Gene symbol

GNGT1

UBE2I

Gene ID

2792

7329

Gene nameG protein subunit gamma transducin 1ubiquitin conjugating enzyme E2 I
SynonymsGNG1C358B7.1|P18|UBC9
Cytomap

7q21.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(T) subunit gamma-T1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1transducin gamma chainSUMO-conjugating enzyme UBC9RING-type E3 SUMO transferase UBC9SUMO-1-protein ligaseSUMO-protein ligaseubiquitin carrier protein 9ubiquitin carrier protein Iubiquitin conjugating enzyme 9ubiquitin conjugating enzyme E2Iubiquitin-conjugating enzyme
Modification date2018052320180523
UniProtAcc

P63211

P63279

Ensembl transtripts involved in fusion geneENST00000455502, ENST00000248572, 
ENST00000429473, ENST00000430875, 
ENST00000428834, 		ENST00000339021, 
ENST00000355803, ENST00000325437, 
ENST00000397514, ENST00000397515, 
ENST00000403747, ENST00000566587, 
ENST00000406620, ENST00000402301, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 5 X 5=125
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNGT1 [Title/Abstract] AND UBE2I [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2I

GO:0016925

protein sumoylation

15660128|19955185|21968017

TgeneUBE2I

GO:0045892

negative regulation of transcription, DNA-templated

16631117

TgeneUBE2I

GO:1903755

positive regulation of SUMO transferase activity

19955185


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW995893GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000455502ENST00000339021GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000355803GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000325437GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000397514GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000397515GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000403747GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000455502ENST00000566587GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000455502ENST00000406620GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000455502ENST00000402301GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000248572ENST00000339021GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000355803GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000325437GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000397514GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000397515GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000403747GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000248572ENST00000566587GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000248572ENST00000406620GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000248572ENST00000402301GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000429473ENST00000339021GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000355803GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000325437GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000397514GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000397515GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000403747GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000429473ENST00000566587GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000429473ENST00000406620GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000429473ENST00000402301GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000430875ENST00000339021GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000355803GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000325437GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000397514GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000397515GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000403747GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000430875ENST00000566587GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000430875ENST00000406620GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000430875ENST00000402301GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000428834ENST00000339021GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000355803GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000325437GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000397514GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000397515GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000403747GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000428834ENST00000566587GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-3UTRENST00000428834ENST00000406620GNGT1chr7

93516673

-UBE2Ichr16

1375024

+
intron-intronENST00000428834ENST00000402301GNGT1chr7

93516673

-UBE2Ichr16

1375024

+

Top

FusionProtFeatures for GNGT1_UBE2I


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNGT1

P63211

UBE2I

P63279

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes theircovalent attachment to other proteins with the help of an E3ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formationof poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5.Essential for nuclear architecture and chromosome segregation.Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333,ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555,ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494,ECO:0000269|PubMed:8668529}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GNGT1_UBE2I


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GNGT1_UBE2I


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GNGT1_UBE2I


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GNGT1_UBE2I


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBE2IC0024667Animal Mammary Neoplasms1CTD_human
TgeneUBE2IC0024668Mammary Neoplasms, Experimental1CTD_human