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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14947

FusionGeneSummary for GNG12_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: GNG12_FAU
Fusion gene ID: 14947
HgeneTgene
Gene symbol

GNG12

FAU

Gene ID

55970

2197

Gene nameG protein subunit gamma 12FAU, ubiquitin like and ribosomal protein S30 fusion
Synonyms-FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

1p31.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12G-protein gamma-12 subunitguanine nucleotide binding protein (G protein), gamma 12ubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052320180522
UniProtAcc

Q9UBI6

P62861

Ensembl transtripts involved in fusion geneENST00000370982, ENST00000494936, 
ENST00000529639, ENST00000531743, 
ENST00000525297, ENST00000527548, 
ENST00000279259, ENST00000529259, 
ENST00000434372, 
Fusion gene scores* DoF score7 X 6 X 7=2947 X 6 X 2=84
# samples 117
** MAII scorelog2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNG12 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA467956GNG12chr1

68659108

-FAUchr11

64888102

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370982ENST00000529639GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000531743GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000525297GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000527548GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000279259GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000529259GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000370982ENST00000434372GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000529639GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000531743GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000525297GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000527548GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000279259GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000529259GNG12chr1

68659108

-FAUchr11

64888102

+
intron-intronENST00000494936ENST00000434372GNG12chr1

68659108

-FAUchr11

64888102

+

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FusionProtFeatures for GNG12_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNG12

Q9UBI6

FAU

P62861

Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNG12_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNG12_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNG12_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNG12_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource