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Fusion gene ID: 14926 |
FusionGeneSummary for GNB1_TXN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNB1_TXN | Fusion gene ID: 14926 | Hgene | Tgene | Gene symbol | GNB1 | TXN | Gene ID | 2782 | 25828 |
| Gene name | G protein subunit beta 1 | thioredoxin 2 | |
| Synonyms | MRD42 | COXPD29|MT-TRX|MTRX|TRX2|TXN | |
| Cytomap | 1p36.33 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1 | thioredoxin, mitochondrialmitochondrial thioredoxin | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P62873 | P10599 | |
| Ensembl transtripts involved in fusion gene | ENST00000378609, ENST00000472614, | ENST00000374515, ENST00000374517, ENST00000487892, | |
| Fusion gene scores | * DoF score | 23 X 23 X 14=7406 | 3 X 3 X 3=27 |
| # samples | 35 | 3 | |
| ** MAII score | log2(35/7406*10)=-4.4032677223393 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GNB1 [Title/Abstract] AND TXN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-LN-A9FR-01A | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000378609 | ENST00000374515 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| 5CDS-intron | ENST00000378609 | ENST00000374517 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| 5CDS-intron | ENST00000378609 | ENST00000487892 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| intron-intron | ENST00000472614 | ENST00000374515 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| intron-intron | ENST00000472614 | ENST00000374517 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
| intron-intron | ENST00000472614 | ENST00000487892 | GNB1 | chr1 | 1721834 | - | TXN | chr9 | 113013144 | - |
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FusionProtFeatures for GNB1_TXN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNB1 | TXN |
| Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GNB1_TXN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GNB1_TXN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNB1 | ARHGEF18, KCNJ3, GNG13, GNG10, GNG4, GNG11, GNGT1, GNGT2, GNG3, GNG5, GNG7, HDAC5, HDAC4, DISC1, ELAVL1, UBQLN1, PLEKHG2, WDR26, GNB2L1, GNG2, RGS6, GNG12, RADIL, RAP1A, PAK1, ATXN10, RASD1, MCF2, KALRN, MCF2L, ADRBK1, PDCL, CCT5, RASD2, SPAG1, BTK, ADRB2, AVPR2, ADRA2A, MRGPRX1, TBXA2R, GNAS, ARRB1, NR3C1, GNAI1, GNAI2, GNAI3, AKT1, ATP6V1B1, GNA11, ESR1, VCAM1, NCF2, MTNR1A, SVIL, PAN2, NOL11, AFP, EPHA7, CYFIP1, GNG8, MTOR, RICTOR, RPTOR, CCDC8, ABCE1, PIK3R5, PIK3CG, COX4I1, GNAQ, NTRK1, FYN, PTK2, CEP128, XPO1, PDLIM7, SYNPO, CUL4A, GLI1, ESRRB, PIK3R1, PIK3CA, DUSP9, COX15, HSD17B10, SOD1, TRIM25, AKT2, PIK3CB | TXN | COL1A1, NCF4, PINX1, VHL, CD40, GAPDH, NR3C1, FST, VIM, TXNIP, MAP3K5, NFKB1, TP53, UCHL5, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, PTPN6, WDR1, UBQLN4, AHCYL1, UBE2V1, SSSCA1, ATP6V1F, SFPQ, SFXN1, UBL5, UBE2D2, SYNCRIP, ATIC, UBE2K, TAX1BP3, PRDX1, MYC, IFIT3, UBL4A, PAN2, NPM1, MYD88, GPRASP2, DYNLT1, CDKN1A, MLH1, NFE2, SIAH1, ACTN4, PARK2, APEX1, SRP9, GPX1, UNK, NTRK1, AKR7A2, ARHGDIA, CCS, EEF2, EIF4EBP2, GLOD4, GSTO1, HINT1, HSPE1, IMPA2, PDCD6, PRDX2, RAB1A, SOD1, STIP1, TAGLN2, TAGLN3, ASS1, C4orf27, ENO1, ENO2, ENO3, FKBP1A, FKBP2, GLRX5, GSTO2, HSPA5, IMPA1, LGALS3, MAP2K2, PGAM1, PGAM2, PSMD14, RAE1, TMX1, TXN2, TYMS, REV3L, PTEN, EWSR1, SRPK2, GEMIN5, TOR1AIP1, EGFR, CRY1, MCM2, OTUB1, PCGF1, DPPA4, NANOG, POU5F1, CRBN, DUSP13, CDK1, COQ2, COX15, DLD, DNM1L, PARK7, SOAT1, VDAC1, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNB1_TXN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNB1_TXN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNB1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Hgene | GNB1 | C0011581 | Depressive disorder | 1 | CTD_human |
| Tgene | TXN | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
| Tgene | TXN | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | TXN | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | TXN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | TXN | C0242488 | Acute Lung Injury | 1 | CTD_human |
| Tgene | TXN | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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