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Fusion gene ID: 14898 |
FusionGeneSummary for GNAZ_MIF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNAZ_MIF | Fusion gene ID: 14898 | Hgene | Tgene | Gene symbol | GNAZ | MIF | Gene ID | 2781 | 6280 |
| Gene name | G protein subunit alpha z | S100 calcium binding protein A9 | |
| Synonyms | gz-alpha | 60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14 | |
| Cytomap | 22q11.22-q11.23 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(z) subunit alphag(x) alpha chainguanine nucleotide binding protein (G protein), alpha z polypeptidetransducin alpha | protein S100-A9MRP-14calgranulin Bcalprotectin L1H subunitleukocyte L1 complex heavy chainmigration inhibitory factor-related protein 14 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P19086 | P14174 | |
| Ensembl transtripts involved in fusion gene | ENST00000248996, ENST00000492538, | ENST00000215754, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 1 X 3=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GNAZ [Title/Abstract] AND MIF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MIF | GO:0002523 | leukocyte migration involved in inflammatory response | 12626582 |
| Tgene | MIF | GO:0006914 | autophagy | 19935772 |
| Tgene | MIF | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 19935772 |
| Tgene | MIF | GO:0030593 | neutrophil chemotaxis | 12626582 |
| Tgene | MIF | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation | 25417112 |
| Tgene | MIF | GO:0035821 | modification of morphology or physiology of other organism | 12874352 |
| Tgene | MIF | GO:0050729 | positive regulation of inflammatory response | 12626582 |
| Tgene | MIF | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12874352 |
| Tgene | MIF | GO:0070488 | neutrophil aggregation | 12626582 |
| Tgene | MIF | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 19935772 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-2019-01A | GNAZ | chr22 | 23412756 | + | MIF | chr22 | 24236959 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000248996 | ENST00000215754 | GNAZ | chr22 | 23412756 | + | MIF | chr22 | 24236959 | + |
| intron-3CDS | ENST00000492538 | ENST00000215754 | GNAZ | chr22 | 23412756 | + | MIF | chr22 | 24236959 | + |
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FusionProtFeatures for GNAZ_MIF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNAZ | MIF |
| Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. | Pro-inflammatory cytokine. Involved in the innate immuneresponse to bacterial pathogens. The expression of MIF at sites ofinflammation suggests a role as mediator in regulating thefunction of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvatetautomerase and dopachrome tautomerase activity (in vitro), butthe physiological substrate is not known. It is not clear whetherthe tautomerase activity has any physiological relevance, andwhether it is important for cytokine activity.{ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:17443469,ECO:0000269|PubMed:23776208}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GNAZ_MIF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GNAZ_MIF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNAZ | RGS19, RGS20, RGS10, EYA2, RAP1GAP, RGS7, ELAVL1, APP, GNAZ, ABCE1, SLC25A41, HOXB5, NUFIP1, FYTTD1, DAAM1, MTHFR, RAP1GDS1, C1orf85, ATP6V0A1, THOC7, TUBB8, RNF123, EPHA4, APOL2, DCAF10, FAM171A2, P2RY8, TMEM185A, CCNL2, GNG3, GJB7, BIRC2, ACBD7, MED21, SDC1, RNASE3, ISG20, PCDHGC3, RD3, GLRX3, DMWD | MIF | GORASP2, FIBP, CD74, BNIPL, COPS5, VHL, STUB1, HSP90AA1, CDK2, NME1, TP53, IGBP1, CLNS1A, VCAM1, FN1, ITGA4, NGFRAP1, UPF2, ZNF408, ASB15, MIF, WDYHV1, CUL7, AKR1C2, LOC101930400, ANXA11, CAPG, COX17, CRIP1, DSTN, ENO1, FSCN1, GBE1, HINT1, LAP3, LDHA, LDHB, MPI, NANP, PABPC1, PAICS, PARK7, PCBP1, PCMT1, PDCD6, PDCD6IP, PIR, SPR, TIMM13, TKT, YKT6, UFM1, CEP290, MKNK2, VPS26A, MCM2, EGFR, CDC73, DLD, SOD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNAZ_MIF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MIF | P14174 | DB04272 | Citric Acid | Macrophage migration inhibitory factor | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for GNAZ_MIF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MIF | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | MIF | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | MIF | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | MIF | C0009319 | Colitis | 1 | CTD_human |
| Tgene | MIF | C0011581 | Depressive disorder | 1 | CTD_human |
| Tgene | MIF | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | MIF | C0022548 | Keloid | 1 | CTD_human |
| Tgene | MIF | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | MIF | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | MIF | C0025261 | Memory Disorders | 1 | CTD_human |
| Tgene | MIF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | MIF | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | MIF | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | MIF | C0243026 | Sepsis | 1 | CTD_human |
| Tgene | MIF | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | MIF | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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