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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14852

FusionGeneSummary for GNAL_GNAL

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAL_GNAL
Fusion gene ID: 14852
HgeneTgene
Gene symbol

GNAL

GNAL

Gene ID

2774

2774

Gene nameG protein subunit alpha LG protein subunit alpha L
SynonymsDYT25DYT25
Cytomap

18p11.21

18p11.21

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(olf) subunit alphaadenylate cyclase-stimulating G alpha protein, olfactory typeguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeguanine nucleotide binding protein guanine nucleotide-binding protein G(olf) subunit alphaadenylate cyclase-stimulating G alpha protein, olfactory typeguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory typeguanine nucleotide binding protein
Modification date2018052320180523
UniProtAcc

P38405

P38405

Ensembl transtripts involved in fusion geneENST00000334049, ENST00000535121, 
ENST00000269162, ENST00000423027, 
ENST00000590972, ENST00000602628, 
ENST00000334049, ENST00000535121, 
ENST00000269162, ENST00000423027, 
ENST00000590972, ENST00000602628, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 5 X 4=140
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAL [Title/Abstract] AND GNAL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX507339GNALchr18

11852054

-GNALchr18

11851484

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000334049ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000334049ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000334049ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000334049ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000334049ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000334049ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000535121ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000269162ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000423027ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000590972ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000334049GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000535121GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000269162GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000423027GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000590972GNALchr18

11852054

-GNALchr18

11851484

+
intron-intronENST00000602628ENST00000602628GNALchr18

11852054

-GNALchr18

11851484

+

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FusionProtFeatures for GNAL_GNAL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAL

P38405

GNAL

P38405

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. G(olf) alpha mediates signal transductionwithin the olfactory neuroepithelium and the basal ganglia. May beinvolved in some aspect of visual transduction, and in mediatingthe effect of one or more hormones/neurotransmitters. Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. G(olf) alpha mediates signal transductionwithin the olfactory neuroepithelium and the basal ganglia. May beinvolved in some aspect of visual transduction, and in mediatingthe effect of one or more hormones/neurotransmitters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNAL_GNAL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNAL_GNAL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNAL_GNAL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNAL_GNAL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNALC0005586Bipolar Disorder1PSYGENET
HgeneGNALC0013421Dystonia1CTD_human
HgeneGNALC0036341Schizophrenia1PSYGENET
HgeneGNALC0393593Dystonia Disorders1CTD_human
HgeneGNALC3554447DYSTONIA 251ORPHANET;UNIPROT
TgeneGNALC0005586Bipolar Disorder1PSYGENET
TgeneGNALC0013421Dystonia1CTD_human
TgeneGNALC0036341Schizophrenia1PSYGENET
TgeneGNALC0393593Dystonia Disorders1CTD_human
TgeneGNALC3554447DYSTONIA 251ORPHANET;UNIPROT