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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1485

FusionGeneSummary for ALDH3A2_SLC47A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH3A2_SLC47A1
Fusion gene ID: 1485
HgeneTgene
Gene symbol

ALDH3A2

SLC47A1

Gene ID

224

55244

Gene namealdehyde dehydrogenase 3 family member A2solute carrier family 47 member 1
SynonymsALDH10|FALDH|SLSMATE1
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionfatty aldehyde dehydrogenasealdehyde dehydrogenase 10aldehyde dehydrogenase family 3 member A2microsomal aldehyde dehydrogenasemultidrug and toxin extrusion protein 1MATE-1hMATE-1multidrug and toxin extrusion 1solute carrier family 47 (multidrug and toxin extrusion), member 1
Modification date2018052320180523
UniProtAcc

P51648

Q96FL8

Ensembl transtripts involved in fusion geneENST00000176643, ENST00000581518, 
ENST00000395575, ENST00000339618, 
ENST00000579855, ENST00000571163, 
ENST00000574597, 
ENST00000584348, 
ENST00000571335, ENST00000436810, 
ENST00000542886, ENST00000457293, 
ENST00000270570, ENST00000575023, 
ENST00000395585, 
Fusion gene scores* DoF score5 X 4 X 5=1005 X 5 X 4=100
# samples 56
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH3A2 [Title/Abstract] AND SLC47A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDH3A2

GO:0006081

cellular aldehyde metabolic process

9133646

HgeneALDH3A2

GO:0046458

hexadecanal metabolic process

25047030

HgeneALDH3A2

GO:0055114

oxidation-reduction process

9133646


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-34-5236-01AALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000176643ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000176643ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000581518ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000395575ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000339618ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000579855ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000571163ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000584348ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000571335ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000436810ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000542886ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000457293ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000270570ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000575023ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+
intron-3UTRENST00000574597ENST00000395585ALDH3A2chr17

19558700

+SLC47A1chr17

19452948

+

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FusionProtFeatures for ALDH3A2_SLC47A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH3A2

P51648

SLC47A1

Q96FL8

Catalyzes the oxidation of long-chain aliphaticaldehydes to fatty acids. Active on a variety of saturated andunsaturated aliphatic aldehydes between 6 and 24 carbons in length(PubMed:9133646, PubMed:22633490, PubMed:25047030). Responsiblefor conversion of the sphingosine 1-phosphate (S1P) degradationproduct hexadecenal to hexadecenoic acid (PubMed:22633490).{ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:25047030,ECO:0000269|PubMed:9133646}. Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide(NMN), metformin, creatinine, guanidine, procainamide, topotecan,estrone sulfate, acyclovir, ganciclovir and also the zwitterioniccephalosporin, cephalexin and cephradin. Seems to also play a rolein the uptake of oxaliplatin (a new platinum anticancer agent).Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium);a widely used herbicid. Responsible for the secretion of cationicdrugs across the brush border membranes.{ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16996621,ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534,ECO:0000269|PubMed:17582384}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ALDH3A2_SLC47A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ALDH3A2_SLC47A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALDH3A2USP50, MME, NELFB, CUL3, CAND1, MMS19, LMNA, EGFR, PPP6R1, PPP6R2, HUWE1, SMPD1, CAND2, DDX20, TBC1D9B, TBC1D15, FANCD2, SAAL1, KIAA1524, HEATR1, GEMIN4, INTS12, XPO4, TSC2, ATR, IPO13, EIF4G3, SMEK2, VPS8, ARFGEF1, LTN1, NCAPH2, INTS3, INTS1, BRAT1, THADA, HOOK2, STAG2, ATP5L, MTCH2, SLC25A3, UQCRQ, ATP6V1C1, BTRC, TCTN2, TCTN3, CEP135, NINL, CEP19, EVC2, TMEM237, TMEM17, TMEM216, CAPZA2, KPNB1, ATL3, C1orf112, TUBA1C, FBXL12, FAF2, CTDNEP1, ALDH3A1, SLC9A6, NCDNSLC47A1PTH1R, GABRE, NT5E, SLC39A4, POMK, ZACN, HTR3C, LYPD6, GPR21, UPK1A, SLC17A2, TCTN2, CHRND, SLC39A12, KIAA1467, HTR3A, TM2D2, ATP2B2, GPR114, CLEC2D, B4GAT1, NRN1, TMPRSS12, TPM2, PTGIR, GABRA3, FAM189B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALDH3A2_SLC47A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ALDH3A2_SLC47A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH3A2C0037231Sjogren-Larsson Syndrome6CTD_human;ORPHANET;UNIPROT
TgeneSLC47A1C0022658Kidney Diseases1CTD_human