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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14841

FusionGeneSummary for GNAI2_PRKAG1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAI2_PRKAG1
Fusion gene ID: 14841
HgeneTgene
Gene symbol

GNAI2

PRKAG1

Gene ID

2771

5571

Gene nameG protein subunit alpha i2protein kinase AMP-activated non-catalytic subunit gamma 1
SynonymsGIP|GNAI2B|H_LUCA15.1|H_LUCA16.1AMPKG
Cytomap

3p21.31

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide5'-AMP-activated protein kinase subunit gamma-15'-AMP-activated protein kinase, gamma-1 subunitAMPK gamma-1 chainAMPK gamma1protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Modification date2018052320180522
UniProtAcc

P04899

P54619

Ensembl transtripts involved in fusion geneENST00000422163, ENST00000491100, 
ENST00000313601, ENST00000536647, 
ENST00000440628, ENST00000451956, 
ENST00000266027, 		ENST00000395170, 
ENST00000547306, ENST00000316299, 
ENST00000548065, ENST00000552212, 
Fusion gene scores* DoF score8 X 7 X 3=1687 X 7 X 3=147
# samples 87
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAI2 [Title/Abstract] AND PRKAG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKAG1

GO:0006468

protein phosphorylation

17028174

TgenePRKAG1

GO:0010628

positive regulation of gene expression

17028174


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK725123GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000422163ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000422163ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000422163ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000422163ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000422163ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000491100ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000491100ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000491100ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000491100ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000491100ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000313601ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000313601ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000313601ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000313601ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000313601ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000536647ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000536647ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000536647ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000536647ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000536647ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000440628ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000440628ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000440628ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000440628ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000440628ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000451956ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000451956ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000451956ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000451956ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
intron-intronENST00000451956ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000266027ENST00000395170GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000266027ENST00000547306GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000266027ENST00000316299GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000266027ENST00000548065GNAI2chr3

50296583

-PRKAG1chr12

49396800

+
3UTR-intronENST00000266027ENST00000552212GNAI2chr3

50296583

-PRKAG1chr12

49396800

+

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FusionProtFeatures for GNAI2_PRKAG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAI2

P04899

PRKAG1

P54619

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems. The G(i) proteins are involved in hormonalregulation of adenylate cyclase: they inhibit the cyclase inresponse to beta-adrenergic stimuli. May play a role in celldivision. {ECO:0000269|PubMed:17635935}. Isoform sGi2: Regulates the cell surface density ofdopamine receptors DRD2 by sequestrating them as an intracellularpool. {ECO:0000269|PubMed:17550964}. AMP/ATP-binding subunit of AMP-activated protein kinase(AMPK), an energy sensor protein kinase that plays a key role inregulating cellular energy metabolism. In response to reduction ofintracellular ATP levels, AMPK activates energy-producing pathwaysand inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis, as well as cell growth andproliferation. AMPK acts via direct phosphorylation of metabolicenzymes, and by longer-term effects via phosphorylation oftranscription regulators. Also acts as a regulator of cellularpolarity by remodeling the actin cytoskeleton; probably byindirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK:AMP-binding results in allosteric activation of alpha catalyticsubunit (PRKAA1 or PRKAA2) both by inducing phosphorylation andpreventing dephosphorylation of catalytic subunits. ADP alsostimulates phosphorylation, without stimulating alreadyphosphorylated catalytic subunit. ATP promotes dephosphorylationof catalytic subunit, rendering the AMPK enzyme inactive.{ECO:0000269|PubMed:21680840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GNAI2_PRKAG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GNAI2_PRKAG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GNAI2_PRKAG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNAI2_PRKAG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNAI2C0004245Atrioventricular Block1CTD_human
HgeneGNAI2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGNAI2C0024667Animal Mammary Neoplasms1CTD_human
HgeneGNAI2C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneGNAI2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneGNAI2C0428977Bradycardia1CTD_human
HgeneGNAI2C1458155Mammary Neoplasms1CTD_human