FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14831

FusionGeneSummary for GNA13_PHF21A

check button Fusion gene summary
Fusion gene informationFusion gene name: GNA13_PHF21A
Fusion gene ID: 14831
HgeneTgene
Gene symbol

GNA13

PHF21A

Gene ID

10672

51317

Gene nameG protein subunit alpha 13PHD finger protein 21A
SynonymsG13BHC80|BM-006
Cytomap

17q24.1

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein subunit alpha-13g alpha-13guanine nucleotide binding protein (G protein), alpha 13PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)
Modification date2018052320180523
UniProtAcc

Q14344

Q96BD5

Ensembl transtripts involved in fusion geneENST00000439174, ENST00000541118, 
ENST00000257821, ENST00000323180, 
ENST00000418153, ENST00000527753, 
Fusion gene scores* DoF score9 X 3 X 8=2167 X 7 X 4=196
# samples 119
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNA13 [Title/Abstract] AND PHF21A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI093849GNA13chr17

63039408

+PHF21Achr11

46105873

-
ChiTaRS3.1AI803563GNA13chr17

63039408

+PHF21Achr11

46105874

-
ChiTaRS3.1AI580083GNA13chr17

63039408

+PHF21Achr11

46105874

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000439174ENST00000257821GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000439174ENST00000323180GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000439174ENST00000418153GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000439174ENST00000527753GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000541118ENST00000257821GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000541118ENST00000323180GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000541118ENST00000418153GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000541118ENST00000527753GNA13chr17

63039408

+PHF21Achr11

46105873

-
intron-intronENST00000439174ENST00000257821GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000439174ENST00000323180GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000439174ENST00000418153GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000439174ENST00000527753GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000541118ENST00000257821GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000541118ENST00000323180GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000541118ENST00000418153GNA13chr17

63039408

+PHF21Achr11

46105874

-
intron-intronENST00000541118ENST00000527753GNA13chr17

63039408

+PHF21Achr11

46105874

-

Top

FusionProtFeatures for GNA13_PHF21A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNA13

Q14344

PHF21A

Q96BD5

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems (PubMed:15240885, PubMed:16787920,PubMed:16705036, PubMed:27084452). Activates effector moleculeRhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF,ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885,PubMed:12515866). GNA13-dependent Rho signaling subsequentlyregulates transcription factor AP-1 (activating protein-1) (Bysimilarity). Promotes tumor cell invasion and metastasis byactivating RhoA/ROCK signaling pathway (PubMed:16787920,PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated celladhesion in process independent from Rho activation(PubMed:11976333). {ECO:0000250|UniProtKB:P27601,ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866,ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036,ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:27084452}. Component of the BHC complex, a corepressor complex thatrepresses transcription of neuron-specific genes in non-neuronalcells. The BHC complex is recruited at RE1/NRSE sites by REST andacts by deacetylating and demethylating specific sites onhistones, thereby acting as a chromatin modifier. In the BHCcomplex, it may act as a scaffold. Inhibits KDM1A-mediateddemethylation of 'Lys-4' of histone H3 in vitro, suggesting a rolein demethylation regulation. {ECO:0000269|PubMed:16140033}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GNA13_PHF21A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GNA13_PHF21A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GNA13_PHF21A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GNA13_PHF21A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNA13C0006413Burkitt Lymphoma1CTD_human