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Fusion gene ID: 14825 |
FusionGeneSummary for GNA13_ASPSCR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNA13_ASPSCR1 | Fusion gene ID: 14825 | Hgene | Tgene | Gene symbol | GNA13 | ASPSCR1 | Gene ID | 10672 | 79058 |
| Gene name | G protein subunit alpha 13 | ASPSCR1, UBX domain containing tether for SLC2A4 | |
| Synonyms | G13 | ASPCR1|ASPL|ASPS|RCC17|TUG|UBXD9|UBXN9 | |
| Cytomap | 17q24.1 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein subunit alpha-13g alpha-13guanine nucleotide binding protein (G protein), alpha 13 | tether containing UBX domain for GLUT4UBX domain protein 9UBX domain-containing protein 9alveolar soft part sarcoma chromosomal region candidate gene 1 proteinalveolar soft part sarcoma chromosome region, candidate 1alveolar soft part sarcoma locusr | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14344 | Q9BZE9 | |
| Ensembl transtripts involved in fusion gene | ENST00000439174, ENST00000541118, | ENST00000306729, ENST00000306739, ENST00000580534, ENST00000581647, ENST00000582404, | |
| Fusion gene scores | * DoF score | 9 X 3 X 8=216 | 6 X 5 X 6=180 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/216*10)=-0.973527788638809 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNA13 [Title/Abstract] AND ASPSCR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | COAD | TCGA-D5-6929-01A | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000439174 | ENST00000306729 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| In-frame | ENST00000439174 | ENST00000306739 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| In-frame | ENST00000439174 | ENST00000580534 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| 5CDS-intron | ENST00000439174 | ENST00000581647 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| 5CDS-intron | ENST00000439174 | ENST00000582404 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| Frame-shift | ENST00000541118 | ENST00000306729 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| Frame-shift | ENST00000541118 | ENST00000306739 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| Frame-shift | ENST00000541118 | ENST00000580534 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| 5CDS-intron | ENST00000541118 | ENST00000581647 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
| 5CDS-intron | ENST00000541118 | ENST00000582404 | GNA13 | chr17 | 63049620 | - | ASPSCR1 | chr17 | 79966913 | + |
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FusionProtFeatures for GNA13_ASPSCR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNA13 | ASPSCR1 |
| Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems (PubMed:15240885, PubMed:16787920,PubMed:16705036, PubMed:27084452). Activates effector moleculeRhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF,ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885,PubMed:12515866). GNA13-dependent Rho signaling subsequentlyregulates transcription factor AP-1 (activating protein-1) (Bysimilarity). Promotes tumor cell invasion and metastasis byactivating RhoA/ROCK signaling pathway (PubMed:16787920,PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated celladhesion in process independent from Rho activation(PubMed:11976333). {ECO:0000250|UniProtKB:P27601,ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866,ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036,ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:27084452}. | Tethering protein that sequesters GLUT4-containingvesicles in the cytoplasm in the absence of insulin. Modulates theamount of GLUT4 that is available at the cell surface (Bysimilarity). Enhances VCP methylation catalyzed by VCPKMT.{ECO:0000250, ECO:0000269|PubMed:23349634}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GNA13 | chr17:63049620 | chr17:79966913 | ENST00000439174 | - | 2 | 4 | 58_63 | 170 | 378 | Nucleotide binding | GTP |
| Tgene | >ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000306729 | + | 6 | 17 | 386_462 | 311 | 648 | Domain | UBX |
| Tgene | >ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000306739 | + | 6 | 16 | 386_462 | 311 | 554 | Domain | UBX |
| Tgene | >ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000580534 | + | 5 | 15 | 386_462 | 234 | 502 | Domain | UBX |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GNA13 | chr17:63049620 | chr17:79966913 | ENST00000439174 | - | 2 | 4 | 197_200 | 170 | 378 | Nucleotide binding | GTP |
| Hgene | >GNA13 | chr17:63049620 | chr17:79966913 | ENST00000439174 | - | 2 | 4 | 291_294 | 170 | 378 | Nucleotide binding | GTP |
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FusionGeneSequence for GNA13_ASPSCR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306729_chr17_79966913_+_507aa MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYS NVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLPVDREPVDRE PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE TVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQPQLGDRVAPFTLGPSLKRCLGPEQRTRLPVVGDGGDVDSGRLLFWGPSRG RASPSTGQPPCHPVCRPSSPPSPRPSSGDPSRVKAGHKHVGTGRANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRA >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306739_chr17_79966913_+_413aa MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYS NVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLPVDREPVDRE PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE TVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSP >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000580534_chr17_79966913_+_438aa MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYS NVIKGMRVLVDAREKLHIPWGDNSNQQHGDKMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLPVDREPVDRE PVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSE TVGDLRDFVRSHLGNPELSFYLCLSSFGRMDGRGPRCFLTRRCLLSSVITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306729_chr17_79966913_+_1521nt ATGGCGGACTTCCTGCCGTCGCGGTCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAG TCCAAGGAGATCGACAAATGCCTGTCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGC AAGTCCACCTTCCTGAAGCAGATGCGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGC AACGTGATCAAAGGTATGAGGGTGCTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGAT AAGATGATGTCGTTTGATACCCGGGCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGA GCATTATGGGCAGACAGCGGCATACAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAG CCGGTGGTGTGCCACCCCGACCTGGAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGAC GTGAGAAGACGCTTGGCCCAGCTCAAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATA AAGGAGAAGCTGGAGCGCTACCCAAAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAG ACAGTGGGGGACTTGCGAGACTTCGTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTTCATCACCCCTCCAAAAACAGTC CTGGACGACCACACGCAGACCCTCTTTCAGCCCCAGCTTGGTGACCGGGTGGCTCCATTCACCCTGGGTCCCTCGCTGAAACGGTGCCTG GGACCAGAGCAGAGAACACGCTTGCCAGTGGTAGGAGATGGAGGCGACGTGGACTCTGGGAGGCTTCTTTTTTGGGGTCCATCCAGAGGC CGAGCCTCTCCAAGCACTGGTCAGCCTCCATGCCACCCAGTCTGCCGACCCTCCTCTCCACCATCCCCTCGTCCGAGCAGTGGCGATCCC TCCCGAGTCAAGGCTGGGCACAAGCACGTGGGGACAGGCCGGGCGAACCTCTTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCG GCAGGTGTCTACCTGGAGCCTGGCCTGCTGGAGCATGCCATCTCCCCATCTGCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCC GCCGGGTCCCCTTCCCCATTGCCAGCCCCTGACCCTGCACCTAAGTCTGAGCCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCC >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306739_chr17_79966913_+_1239nt ATGGCGGACTTCCTGCCGTCGCGGTCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAG TCCAAGGAGATCGACAAATGCCTGTCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGC AAGTCCACCTTCCTGAAGCAGATGCGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGC AACGTGATCAAAGGTATGAGGGTGCTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGAT AAGATGATGTCGTTTGATACCCGGGCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGA GCATTATGGGCAGACAGCGGCATACAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAG CCGGTGGTGTGCCACCCCGACCTGGAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGAC GTGAGAAGACGCTTGGCCCAGCTCAAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATA AAGGAGAAGCTGGAGCGCTACCCAAAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAG ACAGTGGGGGACTTGCGAGACTTCGTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTTCATCACCCCTCCAAAAACAGTC CTGGACGACCACACGCAGACCCTCTTTCAGGCGAACCTCTTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCGGCAGGTGTCTAC CTGGAGCCTGGCCTGCTGGAGCATGCCATCTCCCCATCTGCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCCGCCGGGTCCCCT TCCCCATTGCCAGCCCCTGACCCTGCACCTAAGTCTGAGCCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCCATCCCAGGGACG >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000580534_chr17_79966913_+_1314nt ATGGCGGACTTCCTGCCGTCGCGGTCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAG TCCAAGGAGATCGACAAATGCCTGTCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGC AAGTCCACCTTCCTGAAGCAGATGCGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGC AACGTGATCAAAGGTATGAGGGTGCTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGAT AAGATGATGTCGTTTGATACCCGGGCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGA GCATTATGGGCAGACAGCGGCATACAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAG CCGGTGGTGTGCCACCCCGACCTGGAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGAC GTGAGAAGACGCTTGGCCCAGCTCAAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATA AAGGAGAAGCTGGAGCGCTACCCAAAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAG ACAGTGGGGGACTTGCGAGACTTCGTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTGCCTGTCTTCCTTCGGGCGCATG GATGGGCGAGGTCCACGGTGCTTCCTAACACGTAGGTGCCTTCTCTCCTCAGTCATCACCCCTCCAAAAACAGTCCTGGACGACCACACG CAGACCCTCTTTCAGGCGAACCTCTTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCGGCAGGTGTCTACCTGGAGCCTGGCCTG CTGGAGCATGCCATCTCCCCATCTGCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCCGCCGGGTCCCCTTCCCCATTGCCAGCC CCTGACCCTGCACCTAAGTCTGAGCCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCCATCCCAGGGACGGCCCAGCCCGTGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306729_chr17_79966913_+_1849nt GCTCCGGGGCCACCGCCCCTCCGGGGCCGGGCCCGCCCTCCTTCCCTCCCTCCCTCCCCCGCTGTCCTGGCCCGCCCTGCCCGGCCCGCC CTGCGAGTCAGTTCGCTGGTTCCCTCCCTCCCTGGGCGCGCTCGGGCCGCCGCCGCGCTCCCCGCCCTCGAGCCTCGGTGCCGGAGCCGC CCGCCGCCGGAGGAGGAGGTGGAGGGAGCCGGAGGGGCCCGCCGAGGCGGCGGCGGCGGCGGCAAGATGGCGGACTTCCTGCCGTCGCGG TCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAGTCCAAGGAGATCGACAAATGCCTG TCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACCTTCCTGAAGCAGATG CGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGCAACGTGATCAAAGGTATGAGGGTG CTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGATAAGATGATGTCGTTTGATACCCGG GCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGAGCATTATGGGCAGACAGCGGCATA CAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAGCCGGTGGTGTGCCACCCCGACCTG GAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGACGTGAGAAGACGCTTGGCCCAGCTC AAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATAAAGGAGAAGCTGGAGCGCTACCCA AAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAGACAGTGGGGGACTTGCGAGACTTC GTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTTCATCACCCCTCCAAAAACAGTCCTGGACGACCACACGCAGACCCTC TTTCAGCCCCAGCTTGGTGACCGGGTGGCTCCATTCACCCTGGGTCCCTCGCTGAAACGGTGCCTGGGACCAGAGCAGAGAACACGCTTG CCAGTGGTAGGAGATGGAGGCGACGTGGACTCTGGGAGGCTTCTTTTTTGGGGTCCATCCAGAGGCCGAGCCTCTCCAAGCACTGGTCAG CCTCCATGCCACCCAGTCTGCCGACCCTCCTCTCCACCATCCCCTCGTCCGAGCAGTGGCGATCCCTCCCGAGTCAAGGCTGGGCACAAG CACGTGGGGACAGGCCGGGCGAACCTCTTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCGGCAGGTGTCTACCTGGAGCCTGGC CTGCTGGAGCATGCCATCTCCCCATCTGCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCCGCCGGGTCCCCTTCCCCATTGCCA GCCCCTGACCCTGCACCTAAGTCTGAGCCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCCATCCCAGGGACGGCCCAGCCCGTG AAGAGGAGCCTGGGCAAGGTGCCCAAGTGGCTGAAGCTGCCGGCCAGCAAGAGGTGAGAGCTGCCAGCCTGAGGTGCCCACTCCGCCAGC >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000306739_chr17_79966913_+_1569nt GCTCCGGGGCCACCGCCCCTCCGGGGCCGGGCCCGCCCTCCTTCCCTCCCTCCCTCCCCCGCTGTCCTGGCCCGCCCTGCCCGGCCCGCC CTGCGAGTCAGTTCGCTGGTTCCCTCCCTCCCTGGGCGCGCTCGGGCCGCCGCCGCGCTCCCCGCCCTCGAGCCTCGGTGCCGGAGCCGC CCGCCGCCGGAGGAGGAGGTGGAGGGAGCCGGAGGGGCCCGCCGAGGCGGCGGCGGCGGCGGCAAGATGGCGGACTTCCTGCCGTCGCGG TCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAGTCCAAGGAGATCGACAAATGCCTG TCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACCTTCCTGAAGCAGATG CGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGCAACGTGATCAAAGGTATGAGGGTG CTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGATAAGATGATGTCGTTTGATACCCGG GCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGAGCATTATGGGCAGACAGCGGCATA CAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAGCCGGTGGTGTGCCACCCCGACCTG GAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGACGTGAGAAGACGCTTGGCCCAGCTC AAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATAAAGGAGAAGCTGGAGCGCTACCCA AAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAGACAGTGGGGGACTTGCGAGACTTC GTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTTCATCACCCCTCCAAAAACAGTCCTGGACGACCACACGCAGACCCTC TTTCAGGCGAACCTCTTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCGGCAGGTGTCTACCTGGAGCCTGGCCTGCTGGAGCAT GCCATCTCCCCATCTGCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCCGCCGGGTCCCCTTCCCCATTGCCAGCCCCTGACCCT GCACCTAAGTCTGAGCCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCCATCCCAGGGACGGCCCAGCCCGTGAAGAGGAGCCTG GGCAAGGTGCCCAAGTGGCTGAAGCTGCCGGCCAGCAAGAGGTGAGAGCTGCCAGCCTGAGGTGCCCACTCCGCCAGCCACAGGACCACC >In-frame_GNA13_ENST00000439174_chr17_63049620_-_ASPSCR1_ENST00000580534_chr17_79966913_+_1642nt GCTCCGGGGCCACCGCCCCTCCGGGGCCGGGCCCGCCCTCCTTCCCTCCCTCCCTCCCCCGCTGTCCTGGCCCGCCCTGCCCGGCCCGCC CTGCGAGTCAGTTCGCTGGTTCCCTCCCTCCCTGGGCGCGCTCGGGCCGCCGCCGCGCTCCCCGCCCTCGAGCCTCGGTGCCGGAGCCGC CCGCCGCCGGAGGAGGAGGTGGAGGGAGCCGGAGGGGCCCGCCGAGGCGGCGGCGGCGGCGGCAAGATGGCGGACTTCCTGCCGTCGCGG TCCGTGCTGTCCGTGTGCTTCCCCGGCTGCCTGCTGACGAGTGGCGAGGCCGAGCAGCAACGCAAGTCCAAGGAGATCGACAAATGCCTG TCTCGGGAAAAGACCTATGTGAAGCGGCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACCTTCCTGAAGCAGATG CGGATCATCCACGGGCAGGACTTCGACCAGCGCGCGCGCGAGGAGTTCCGCCCCACCATCTACAGCAACGTGATCAAAGGTATGAGGGTG CTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAACCAACAACATGGAGATAAGATGATGTCGTTTGATACCCGG GCCCCCATGGCAGCCCAAGGAATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGAGCATTATGGGCAGACAGCGGCATA CAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGCCCGTGGACCGGGAGCCCGTGGACCGGGAGCCGGTGGTGTGCCACCCCGACCTG GAGGAGCGGCTGCAGGCCTGGCCAGCGGAGCTGCCTGATGAGTTCTTTGAGCTGACGGTGGACGACGTGAGAAGACGCTTGGCCCAGCTC AAGAGTGAGCGGAAGCGCCTGGAAGAAGCCCCCTTGGTGACCAAGGCCTTCAGGGAGGCGCAGATAAAGGAGAAGCTGGAGCGCTACCCA AAGGTGGCTCTGAGGGTCCTGTTCCCCGACCGCTACGTCCTACAGGGCTTCTTCCGCCCCAGCGAGACAGTGGGGGACTTGCGAGACTTC GTGAGGAGCCACCTGGGGAACCCCGAGCTGTCATTTTACCTGTGCCTGTCTTCCTTCGGGCGCATGGATGGGCGAGGTCCACGGTGCTTC CTAACACGTAGGTGCCTTCTCTCCTCAGTCATCACCCCTCCAAAAACAGTCCTGGACGACCACACGCAGACCCTCTTTCAGGCGAACCTC TTCCCGGCCGCTCTGGTGCACTTGGGAGCCGAGGAGCCGGCAGGTGTCTACCTGGAGCCTGGCCTGCTGGAGCATGCCATCTCCCCATCT GCGGCCGATGTGCTGGTGGCCAGGTACATGTCCAGGGCCGCCGGGTCCCCTTCCCCATTGCCAGCCCCTGACCCTGCACCTAAGTCTGAG CCAGCTGCTGAGGAGGGGGCGCTGGTCCCCCCTGAGCCCATCCCAGGGACGGCCCAGCCCGTGAAGAGGAGCCTGGGCAAGGTGCCCAAG TGGCTGAAGCTGCCGGCCAGCAAGAGGTGAGAGCTGCCAGCCTGAGGTGCCCACTCCGCCAGCCACAGGACCACCTCCTCTGCCAGCAGG |
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FusionGenePPI for GNA13_ASPSCR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNA13 | AKAP3, CDH1, CDH2, RGS16, ARHGEF1, DRD5, PPP5C, PRKCB, PRKCE, PRKCD, RDX, PTK2B, PRKAR2A, ARHGEF12, TEC, F2R, TBXA2R, MCF2, RIC8A, ARHGEF11, MAP3K5, ARHGEF28, USP3, AIP, ELAVL1, LRRK2, PRKACA, GNG2, AHR, CXCR5, CXCR4, CUL7, CCDC8, PHF19, SLC25A41, HOXB5, TAS2R7, FYTTD1, GNAI1, CCR1, TMEM185A, FAM63B, RD3, NTRK1, HERC2, GLI1, CDC73, GNG3, CYP2S1, PVR, FANCE, DUSP22, S1PR1, GNG4, TMEM206, TRIM25 | ASPSCR1 | UBC, VCP, ALPP, NPLOC4, UFD1L, VCPIP1, PHAX, NEDD4, UBXN6, APP, VCPKMT, DCAF11, KRT31, TCF4, TACC3, ADAMTSL4, KRTAP10-8, NOTCH2NL, EZH2, GAPDH, GLUL, UBXN2B, HPD, MAT1A, NSF, AGL, BANF1, DERA, YTHDF1, YTHDF2, NTRK1, UBXN2A, UBXN7, NSFL1C, UBXN10, FAF1, KCTD3, FAM136A, SHKBP1, HAO2, ASNA1, HK1, HACL1, SERPINB2, GLTP, FADS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000306729 | + | 6 | 17 | 317_380 | 311 | 648 | GLUT4 |
| Tgene | ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000306739 | + | 6 | 16 | 317_380 | 311 | 554 | GLUT4 |
| Tgene | ASPSCR1 | chr17:63049620 | chr17:79966913 | ENST00000580534 | + | 5 | 15 | 317_380 | 234 | 502 | GLUT4 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNA13_ASPSCR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNA13_ASPSCR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNA13 | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
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