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Fusion gene ID: 14818 |
FusionGeneSummary for GNA12_ADSS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNA12_ADSS | Fusion gene ID: 14818 | Hgene | Tgene | Gene symbol | GNA12 | ADSS | Gene ID | 2768 | 159 |
| Gene name | G protein subunit alpha 12 | adenylosuccinate synthase | |
| Synonyms | NNX3|RMP|gep | ADEH|ADSS 2 | |
| Cytomap | 7p22.3-p22.2 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12 | adenylosuccinate synthetase isozyme 2AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetaseadSS 2adenylosuccinate synthetase (Ade(-)H-complementing)adenylosuccinate synthetase, acidic isozymeadenylosuccinate synthetase, liver isozyme | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q03113 | P30520 | |
| Ensembl transtripts involved in fusion gene | ENST00000275364, ENST00000544127, ENST00000491117, ENST00000407904, ENST00000407653, ENST00000396960, | ENST00000366535, ENST00000462358, | |
| Fusion gene scores | * DoF score | 7 X 2 X 4=56 | 3 X 1 X 3=9 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/56*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GNA12 [Title/Abstract] AND ADSS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ADSS | GO:0006167 | AMP biosynthetic process | 2004783 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A1N6-01A | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000275364 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000275364 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| In-frame | ENST00000544127 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000544127 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-3CDS | ENST00000491117 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-intron | ENST00000491117 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| In-frame | ENST00000407904 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| 5CDS-intron | ENST00000407904 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-3CDS | ENST00000407653 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-intron | ENST00000407653 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-3CDS | ENST00000396960 | ENST00000366535 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
| intron-intron | ENST00000396960 | ENST00000462358 | GNA12 | chr7 | 2834562 | - | ADSS | chr1 | 244601070 | - |
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FusionProtFeatures for GNA12_ADSS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GNA12 | ADSS |
| Plays an important role in the de novo pathway and inthe salvage pathway of purine nucleotide biosynthesis. Catalyzesthe first committed step in the biosynthesis of AMP from IMP. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GNA12 | chr7:2834562 | chr1:244601070 | ENST00000275364 | - | 2 | 4 | 67_72 | 175 | 382 | Nucleotide binding | GTP |
| Tgene | >ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 362_364 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 444_447 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 67_69 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | >ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 330_336 | 61 | 457 | Region | Substrate binding |
| Tgene | >ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 65_68 | 61 | 457 | Region | IMP binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GNA12 | chr7:2834562 | chr1:244601070 | ENST00000275364 | - | 2 | 4 | 202_205 | 175 | 382 | Nucleotide binding | GTP |
| Hgene | >GNA12 | chr7:2834562 | chr1:244601070 | ENST00000275364 | - | 2 | 4 | 296_299 | 175 | 382 | Nucleotide binding | GTP |
| Tgene | ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 39_45 | 61 | 457 | Nucleotide binding | Note=GTP |
| Tgene | ADSS | chr7:2834562 | chr1:244601070 | ENST00000366535 | - | 0 | 13 | 40_43 | 61 | 457 | Region | IMP binding |
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FusionGeneSequence for GNA12_ADSS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_571aa MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL LEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGGNNA GHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAG KNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPP KKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKR RCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQ >In-frame_GNA12_ENST00000544127_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_495aa MRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREA FSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQA ADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVR DGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQ TRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDI >In-frame_GNA12_ENST00000407904_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_512aa MKRRMFPRPCLARMPGSRGSGSTPDGNRKCCRFEHLLIAHPGSRGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQL YVPALSALWRDSGIREAFSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEK RLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEG ELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVG IGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_1713nt ATGTCCGGGGTGGTGCGGACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGC GACGCGGAGCGCGAGGCCCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATC CTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTG CTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAG TATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTAC GTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCT GGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGA AATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGG CTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGA AAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCT GACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAA TTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCA AAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTT GGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATT GGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGA AGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTG GACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAAT AAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAA AACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTT >In-frame_GNA12_ENST00000544127_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_1485nt ATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGG GTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAAC AAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCT TTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTA CCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAA AATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCA GCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCC AAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATAC AAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGA GATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGAT TTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAA GTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAA ACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATC AATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGT GAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATA TCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGG >In-frame_GNA12_ENST00000407904_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_1536nt ATGAAACGGAGAATGTTTCCCAGGCCGTGCCTAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGC TGCCGTTTTGAGCACCTACTCATTGCACACCCTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGG CAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTG TACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAAT GCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATT GGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAA AGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCA GGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTT TCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGT GAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCA CCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACT GTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGT ATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAA AGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATT TTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTA AATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCA CAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GNA12_ENST00000275364_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_2968nt GGCGACGAGTGCGGGCCTCGGAGCGACTGCAGCGGCGGCGGCGGACGCGGCCTGAGGCGAGCGGCGGGGCGTGGGGCGGTGCCTCGGCCC GGGCTCGCCCTCGCCGGCGGGAGCGTCCATGGCCCCCGGGCGCCGGCGGGGCGCGGCCGCGGCCTGAGGGGCCATGTCCGGGGTGGTGCG GACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGCGACGCGGAGCGCGAGGC CCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGG CGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACAC CATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAA GCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGC ACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGT GGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCA TCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAG AGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAAC AAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTC TGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGG TTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGA AGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGG TTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGA GCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGA CCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAAT CAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATA TAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTAT TGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAAT GCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTA AGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTT AGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTT GTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTA AGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATG AAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTG AGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATAC ATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGT AATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTA GTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTT GATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATG >In-frame_GNA12_ENST00000544127_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_2660nt GCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCA TCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTG TTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGG GGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCC GGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTG GAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTC AAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATG GTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTG CTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTA TATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAG TTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGA CTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATG GAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGG GTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGAT TTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCA TACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATG CAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTG TTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTT CTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGAT GGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTC TCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTT TTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACAT TCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGA ATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGG GACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGT TTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTA CCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCT ACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAG GTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTT >In-frame_GNA12_ENST00000407904_chr7_2834562_-_ADSS_ENST00000366535_chr1_244601070_-_2957nt ATTTAAGCAGCCTCCTTGACTGTAGGTCCGCTGACTGGCTTCCTCCTTGAGAGCACACTCACAGTGCCGGACCGCAGGCACCTCGCCGAT GTTCCTGTCCACTTGCTTTTTGTATTGCTCCTTCTCCAGTGAGCTTGGAAGCCTCATGCGGGCAAGGCCTTGTCTGTCTGGTTCTCTGTT GTGTCCTCGGAGCCTGCCACAGTGGCGGCGCTTGGTGGCTTTGACAGGGGACTGGATTGGGTGGAAGGGGCGAGATTAGACCTGGATACA GTGACGTCCTTGTCAGCCATGCCGAGTGCAGAGCGCCTACTGTATTGTAGGCATTTGAAATGAAACGGAGAATGTTTCCCAGGCCGTGCC TAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGCTGCCGTTTTGAGCACCTACTCATTGCACACC CTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGT TCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGG ATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGG AATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGAT TGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTG TATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCA TTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTA AAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAA AGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATG CAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGC CACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATG AAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGC TCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAG TTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCC CAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGC TTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACAC TCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCC CTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTG CCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCA AAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAA TGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGG GTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGG GGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTT AGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTG GATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTT TTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTT TATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAA |
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FusionGenePPI for GNA12_ADSS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GNA12 | CDH15, CDH1, CDH2, AKAP13, ARHGEF1, DRD5, PPP5C, S1PR4, PRKCB, PRKCE, PRKCD, ARHGEF12, TEC, F2R, TBXA2R, HSP90AA1, ARHGEF11, MAP3K5, ARHGEF28, PCK1, LRRK2, APP, IL3RA, GNB3, ARAF, GNAS, CDC73 | ADSS | ATG10, CUL3, RNH1, SGTA, SMYD1, ANXA6, CBX3, CHMP4A, CHRAC1, DCK, GSR, IDH1, MAPK14, OXCT1, THOP1, FDPS, HSPE1, KYNU, PDIA3, PTMS, RBBP7, TALDO1, WDR1, AASDHPPT, CTBP1, OAT, AGL, ARFIP1, C6orf211, GART, GNPNAT1, HSD17B10, IMPA2, NME1-NME2, NME2, PCBD1, PFKL, RPE, TANGO2, UMPS, ADSSL1, NPB, LGALS7, TRIM25, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GNA12_ADSS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GNA12_ADSS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GNA12 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Hgene | GNA12 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | GNA12 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | GNA12 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | ADSS | C0036341 | Schizophrenia | 1 | PSYGENET |
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