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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14807

FusionGeneSummary for GMIP_SLC6A9

check button Fusion gene summary
Fusion gene informationFusion gene name: GMIP_SLC6A9
Fusion gene ID: 14807
HgeneTgene
Gene symbol

GMIP

SLC6A9

Gene ID

51291

6536

Gene nameGEM interacting proteinsolute carrier family 6 member 9
SynonymsARHGAP46GCENSG|GLYT1
Cytomap

19p13.11

1p34.1

Type of geneprotein-codingprotein-coding
DescriptionGEM-interacting proteinsodium- and chloride-dependent glycine transporter 1glyT-1solute carrier family 6 (neurotransmitter transporter, glycine), member 9
Modification date2018051920180523
UniProtAcc

Q9P107

P48067

Ensembl transtripts involved in fusion geneENST00000203556, ENST00000445806, 
ENST00000587238, ENST00000586269, 
ENST00000372307, ENST00000372306, 
ENST00000372310, ENST00000475075, 
ENST00000360584, ENST00000357730, 
ENST00000537678, ENST00000492434, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GMIP [Title/Abstract] AND SLC6A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMIP

GO:0034260

negative regulation of GTPase activity

12093360

HgeneGMIP

GO:0035556

intracellular signal transduction

12093360


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF801161GMIPchr19

19744885

+SLC6A9chr1

44468836

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000203556ENST00000372307GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000372306GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000372310GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000475075GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000360584GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000357730GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000537678GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000203556ENST00000492434GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000372307GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000372306GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000372310GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000475075GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000360584GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000357730GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000537678GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000445806ENST00000492434GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000372307GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000372306GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000372310GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000475075GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000360584GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000357730GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000537678GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000587238ENST00000492434GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000372307GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000372306GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000372310GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000475075GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000360584GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000357730GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000537678GMIPchr19

19744885

+SLC6A9chr1

44468836

-
intron-intronENST00000586269ENST00000492434GMIPchr19

19744885

+SLC6A9chr1

44468836

-

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FusionProtFeatures for GMIP_SLC6A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GMIP

Q9P107

SLC6A9

P48067

Stimulates, in vitro and in vivo, the GTPase activity ofRhoA. {ECO:0000269|PubMed:12093360}. Terminates the action of glycine by its high affinitysodium-dependent reuptake into presynaptic terminals. May play arole in regulation of glycine levels in NMDA receptor-mediatedneurotransmission.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GMIP_SLC6A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GMIP_SLC6A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GMIP_SLC6A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC6A9P48067DB00145GlycineSodium- and chloride-dependent glycine transporter 1small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for GMIP_SLC6A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGMIPC0041696Unipolar Depression1PSYGENET
HgeneGMIPC1269683Major Depressive Disorder1PSYGENET
TgeneSLC6A9C0036341Schizophrenia4PSYGENET
TgeneSLC6A9C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneSLC6A9C0033975Psychotic Disorders1PSYGENET
TgeneSLC6A9C0236733Amphetamine-Related Disorders1CTD_human
TgeneSLC6A9C0349204Nonorganic psychosis1PSYGENET