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Fusion gene ID: 14805 |
FusionGeneSummary for GMEB2_STMN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GMEB2_STMN3 | Fusion gene ID: 14805 | Hgene | Tgene | Gene symbol | GMEB2 | STMN3 | Gene ID | 26205 | 50861 |
| Gene name | glucocorticoid modulatory element binding protein 2 | stathmin 3 | |
| Synonyms | GMEB-2|P79PIF|PIF79 | SCLIP | |
| Cytomap | 20q13.33 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glucocorticoid modulatory element-binding protein 2DNA-binding protein p79PIFPIF p79parvovirus initiation factor, p79 | stathmin-3SCG10-like proteinstathmin-like 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UKD1 | Q9NZ72 | |
| Ensembl transtripts involved in fusion gene | ENST00000370069, ENST00000266068, ENST00000370077, | ENST00000370053, ENST00000540534, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GMEB2 [Title/Abstract] AND STMN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A8OQ-01A | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370069 | ENST00000370053 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| 5CDS-5UTR | ENST00000370069 | ENST00000540534 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| In-frame | ENST00000266068 | ENST00000370053 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| 5CDS-5UTR | ENST00000266068 | ENST00000540534 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| Frame-shift | ENST00000370077 | ENST00000370053 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
| 5CDS-5UTR | ENST00000370077 | ENST00000540534 | GMEB2 | chr20 | 62223375 | - | STMN3 | chr20 | 62275662 | - |
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FusionProtFeatures for GMEB2_STMN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GMEB2 | STMN3 |
| Trans-acting factor that binds to glucocorticoidmodulatory elements (GME) present in the TAT (tyrosineaminotransferase) promoter and increases sensitivity to lowconcentrations of glucocorticoids. Binds also to the transferrinreceptor promoter. Essential auxiliary factor for the replicationof parvoviruses. | Exhibits microtubule-destabilizing activity, which isantagonized by STAT3. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000266068 | - | 8 | 9 | 57_64 | 317 | 531 | Compositional bias | Note=Poly-Ala |
| Hgene | GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000370077 | - | 9 | 10 | 57_64 | 317 | 531 | Compositional bias | Note=Poly-Ala |
| Hgene | GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000266068 | - | 8 | 9 | 81_163 | 317 | 531 | Domain | SAND |
| Hgene | GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000370077 | - | 9 | 10 | 81_163 | 317 | 531 | Domain | SAND |
| Tgene | >STMN3 | chr20:62223375 | chr20:62275662 | ENST00000370053 | - | 0 | 5 | 75_179 | 6 | 181 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >STMN3 | chr20:62223375 | chr20:62275662 | ENST00000370053 | - | 0 | 5 | 38_180 | 6 | 181 | Domain | SLD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000266068 | - | 8 | 9 | 304_348 | 317 | 531 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >GMEB2 | chr20:62223375 | chr20:62275662 | ENST00000370077 | - | 9 | 10 | 304_348 | 317 | 531 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for GMEB2_STMN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GMEB2_STMN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GMEB2 | ATXN1, ATXN1L, CBFA2T3, SHMT2, MOV10, NXF1, EWSR1, GMEB1, CD44, SDC2, SDC1 | STMN3 | TRPC5, UBQLN1, NKX3-1, GLP1R |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GMEB2_STMN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GMEB2_STMN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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