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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14786

FusionGeneSummary for GMDS_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: GMDS_BCAS3
Fusion gene ID: 14786
HgeneTgene
Gene symbol

GMDS

BCAS3

Gene ID

2762

54828

Gene nameGDP-mannose 4,6-dehydrataseBCAS3, microtubule associated cell migration factor
SynonymsGMD|SDR3E1GAOB1|MAAB
Cytomap

6p25.3

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionGDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

O60547

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000530927, ENST00000380815, 
ENST00000467288, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score17 X 9 X 11=168326 X 15 X 15=5850
# samples 1741
** MAII scorelog2(17/1683*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GMDS [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMDS

GO:0019673

GDP-mannose metabolic process

9525924

HgeneGMDS

GO:0042351

'de novo' GDP-L-fucose biosynthetic process

9525924

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-A7NF-01AGMDSchr6

1624041

-BCAS3chr17

59465980

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000530927ENST00000589222GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000407086GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000390652GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000408905GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000588462GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000585744GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000588874GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000530927ENST00000585812GMDSchr6

1624041

-BCAS3chr17

59465980

+
Frame-shitENST00000380815ENST00000589222GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000407086GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000390652GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000408905GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000588462GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000585744GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000588874GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000380815ENST00000585812GMDSchr6

1624041

-BCAS3chr17

59465980

+
Frame-shitENST00000467288ENST00000589222GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000407086GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000390652GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000408905GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000588462GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000585744GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000588874GMDSchr6

1624041

-BCAS3chr17

59465980

+
5CDS-intronENST00000467288ENST00000585812GMDSchr6

1624041

-BCAS3chr17

59465980

+

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FusionProtFeatures for GMDS_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GMDS

O60547

BCAS3

Q9H6U6

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GMDS_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GMDS_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GMDSGMDS, TNKS, BLVRB, BAG3, ATIC, CAPN2, CTH, NSFL1C, PTMA, RAP1GDS1, TATDN1, WDYHV1, RNF166, MAT2B, RAB2A, TTC5, NDUFA9, PSMG4, CCDC22, SKA1, NF2, FBXW7, TNKS2, HIF1AN, NPHP3BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GMDS_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GMDS_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource