FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14782

FusionGeneSummary for GLYR1_SRL

check button Fusion gene summary
Fusion gene informationFusion gene name: GLYR1_SRL
Fusion gene ID: 14782
HgeneTgene
Gene symbol

GLYR1

SRL

Gene ID

84656

6345

Gene nameglyoxylate reductase 1 homologsarcalumenin
SynonymsBM045|HIBDL|N-PAC|NP60SAR
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionputative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDasarcalumenin
Modification date2018052320180329
UniProtAcc

Q49A26

Q86TD4

Ensembl transtripts involved in fusion geneENST00000436648, ENST00000321919, 
ENST00000381983, ENST00000591451, 
ENST00000586901, 
ENST00000399609, 
ENST00000537996, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 2 X 2=12
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GLYR1 [Title/Abstract] AND SRL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1560-01AGLYR1chr16

4895075

-SRLchr16

4245787

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000436648ENST00000399609GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000436648ENST00000537996GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000321919ENST00000399609GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000321919ENST00000537996GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000381983ENST00000399609GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000381983ENST00000537996GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000591451ENST00000399609GLYR1chr16

4895075

-SRLchr16

4245787

-
Frame-shiftENST00000591451ENST00000537996GLYR1chr16

4895075

-SRLchr16

4245787

-
intron-3CDSENST00000586901ENST00000399609GLYR1chr16

4895075

-SRLchr16

4245787

-
intron-3CDSENST00000586901ENST00000537996GLYR1chr16

4895075

-SRLchr16

4245787

-

Top

FusionProtFeatures for GLYR1_SRL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLYR1

Q49A26

SRL

Q86TD4

May be involved in the regulation of calcium transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GLYR1_SRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GLYR1_SRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLYR1ELAVL1, SIRT7, DHX9, ESR1, GEMIN4, KDM1A, WHSC1L1, CCNC, FHL2, EIF1AD, C6orf165, HIST3H3, SUZ12, EED, RNF2, RPL8, NPM1, MAGEA1, PRR11, ILF2, NEFH, BLK, HAL, KDM1B, LCP1, SERPINA12, CAPNS2, FNTB, ALOXE3, DDX18, FBL, NOP56, NOP58, RCC1, RFC1, TOP2A, TOP2B, NOC2L, IFI16, MED4, HIST1H3E, HNRNPU, FOXL2, CDC14B, WDR46, ZNF2, RPL37A, GLTSCR2, RPL28, CNBP, DGCR8, HIST1H1E, RPL30, ZC3HAV1, RRP8, STAU1, ZCRB1, H2AFY2, PRDM5, PPAN, RPL18A, FGF8, GPATCH4, PDGFB, CDX1, ECM1, PLEKHO1, RRS1, RSBN1, RBM4, RBM34, KNOP1, HIST1H3ASRL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GLYR1_SRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GLYR1_SRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource