	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 14781

FusionGeneSummary for GLYR1_ELAVL4

Fusion gene summary

Fusion gene information	Fusion gene name: GLYR1_ELAVL4
	Fusion gene ID: 14781
		Hgene	Tgene
	Gene symbol	GLYR1	ELAVL4
	Gene ID	84656	1996
	Gene name	glyoxylate reductase 1 homolog	ELAV like RNA binding protein 4
	Synonyms	BM045\|HIBDL\|N-PAC\|NP60	HUD\|PNEM
	Cytomap	16p13.3	1p33-p32.3
	Type of gene	protein-coding	protein-coding
	Description	putative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDa	ELAV-like protein 4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)ELAV like neuron-specific RNA binding protein 4Hu antigen Dparaneoplastic encephalomyelitis antigen HuD
	Modification date	20180523	20180519
	UniProtAcc	Q49A26	P26378
	Ensembl transtripts involved in fusion gene	ENST00000436648, ENST00000321919, ENST00000381983, ENST00000591451, ENST00000586901,	ENST00000448907, ENST00000371827, ENST00000357083, ENST00000371824, ENST00000371823, ENST00000371821, ENST00000371819, ENST00000492299,
Fusion gene scores	* DoF score	5 X 4 X 4=80	3 X 3 X 2=18
	# samples	5	3
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GLYR1 [Title/Abstract] AND ELAVL4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BC003693	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000436648	ENST00000448907	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000371827	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000357083	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000371824	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000371823	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000371821	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000371819	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000436648	ENST00000492299	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000448907	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000371827	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000357083	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000371824	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000371823	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000371821	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000371819	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000321919	ENST00000492299	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000448907	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000371827	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000357083	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000371824	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000371823	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000371821	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000371819	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000381983	ENST00000492299	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000448907	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000371827	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000357083	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000371824	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000371823	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000371821	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000371819	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000591451	ENST00000492299	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000448907	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000371827	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000357083	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000371824	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000371823	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000371821	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000371819	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+
intron-intron	ENST00000586901	ENST00000492299	GLYR1	chr16	4854935	-	ELAVL4	chr1	50539308	+

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FusionProtFeatures for GLYR1_ELAVL4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GLYR1 Q49A26	ELAVL4 P26378
	May play a role in neuron-specific RNA processing.Protects CDKN1A mRNA from decay by binding to its 3'-UTR (Bysimilarity). Binds to AU-rich sequences (AREs) of target mRNAs,including VEGF and FOS mRNA. {ECO:0000250,ECO:0000269\|PubMed:10710437, ECO:0000269\|PubMed:7898713}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for GLYR1_ELAVL4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLYR1_ELAVL4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for GLYR1_ELAVL4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GLYR1_ELAVL4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 14781

FusionGeneSummary for GLYR1_ELAVL4

FusionProtFeatures for GLYR1_ELAVL4

FusionGeneSequence for GLYR1_ELAVL4

FusionGenePPI for GLYR1_ELAVL4

RelatedDrugs for GLYR1_ELAVL4

RelatedDiseases for GLYR1_ELAVL4