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Fusion gene ID: 14772 |
FusionGeneSummary for GLUL_SLC24A2 |
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Fusion gene information | Fusion gene name: GLUL_SLC24A2 | Fusion gene ID: 14772 | Hgene | Tgene | Gene symbol | GLUL | SLC24A2 | Gene ID | 2752 | 25769 |
Gene name | glutamate-ammonia ligase | solute carrier family 24 member 2 | |
Synonyms | GLNS|GS|PIG43|PIG59 | NCKX2 | |
Cytomap | 1q25.3 | 9p22.1-p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | glutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43 | sodium/potassium/calcium exchanger 2Na(+)/K(+)/Ca(2+)-exchange protein 2retinal cone Na-Ca+K exchangersolute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P15104 | Q9UI40 | |
Ensembl transtripts involved in fusion gene | ENST00000331872, ENST00000417584, ENST00000311223, ENST00000491322, ENST00000339526, | ENST00000341998, ENST00000286344, | |
Fusion gene scores | * DoF score | 11 X 10 X 4=440 | 6 X 6 X 5=180 |
# samples | 17 | 7 | |
** MAII score | log2(17/440*10)=-1.37196877738696 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GLUL [Title/Abstract] AND SLC24A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GLUL | GO:0008283 | cell proliferation | 18662667 |
Tgene | SLC24A2 | GO:0034220 | ion transmembrane transport | 18166528 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE765952 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - | ||
ChiTaRS3.1 | BE765994 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000331872 | ENST00000341998 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-intron | ENST00000331872 | ENST00000286344 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-3UTR | ENST00000417584 | ENST00000341998 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-intron | ENST00000417584 | ENST00000286344 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-3UTR | ENST00000311223 | ENST00000341998 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-intron | ENST00000311223 | ENST00000286344 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-3UTR | ENST00000491322 | ENST00000341998 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-intron | ENST00000491322 | ENST00000286344 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-3UTR | ENST00000339526 | ENST00000341998 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-intron | ENST00000339526 | ENST00000286344 | GLUL | chr1 | 182352479 | - | SLC24A2 | chr9 | 19509293 | - |
intron-3UTR | ENST00000331872 | ENST00000341998 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-intron | ENST00000331872 | ENST00000286344 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-3UTR | ENST00000417584 | ENST00000341998 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-intron | ENST00000417584 | ENST00000286344 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-3UTR | ENST00000311223 | ENST00000341998 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-intron | ENST00000311223 | ENST00000286344 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-3UTR | ENST00000491322 | ENST00000341998 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-intron | ENST00000491322 | ENST00000286344 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-3UTR | ENST00000339526 | ENST00000341998 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
intron-intron | ENST00000339526 | ENST00000286344 | GLUL | chr1 | 182352482 | - | SLC24A2 | chr9 | 19509294 | - |
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FusionProtFeatures for GLUL_SLC24A2 |
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Hgene | Tgene |
GLUL | SLC24A2 |
This enzyme has 2 functions: it catalyzes the productionof glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA),the latter in a pyridoxal phosphate-independent manner (Bysimilarity). Essential for proliferation of fetal skinfibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}. | Critical component of the visual transduction cascade,controlling the calcium concentration of outer segments duringlight and darkness. Light causes a rapid lowering of cytosolicfree calcium in the outer segment of both retinal rod and conephotoreceptors and the light-induced lowering of calcium is causedby extrusion via this protein which plays a key role in theprocess of light adaptation. Transports 1 Ca(2+) and 1 K(+) inexchange for 4 Na(+). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GLUL_SLC24A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GLUL_SLC24A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLUL_SLC24A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GLUL | P15104 | DB00130 | L-Glutamine | Glutamine synthetase | small molecule | approved|investigational|nutraceutical |
Hgene | GLUL | P15104 | DB00142 | Glutamic Acid | Glutamine synthetase | small molecule | approved|nutraceutical |
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RelatedDiseases for GLUL_SLC24A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GLUL | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | GLUL | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Hgene | GLUL | C0023904 | Liver Neoplasms, Experimental | 2 | CTD_human |
Hgene | GLUL | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | GLUL | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | GLUL | C0019151 | Hepatic Encephalopathy | 1 | CTD_human |
Hgene | GLUL | C0028754 | Obesity | 1 | CTD_human |
Hgene | GLUL | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | GLUL | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Hgene | GLUL | C0525045 | Mood Disorders | 1 | PSYGENET |
Hgene | GLUL | C0752109 | Brain Diseases, Metabolic, Inborn | 1 | CTD_human |
Hgene | GLUL | C1864910 | Glutamine deficiency, congenital | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | GLUL | C2239176 | Liver carcinoma | 1 | CTD_human |