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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14772

FusionGeneSummary for GLUL_SLC24A2

check button Fusion gene summary
Fusion gene informationFusion gene name: GLUL_SLC24A2
Fusion gene ID: 14772
HgeneTgene
Gene symbol

GLUL

SLC24A2

Gene ID

2752

25769

Gene nameglutamate-ammonia ligasesolute carrier family 24 member 2
SynonymsGLNS|GS|PIG43|PIG59NCKX2
Cytomap

1q25.3

9p22.1-p21.3

Type of geneprotein-codingprotein-coding
Descriptionglutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43sodium/potassium/calcium exchanger 2Na(+)/K(+)/Ca(2+)-exchange protein 2retinal cone Na-Ca+K exchangersolute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Modification date2018052220180523
UniProtAcc

P15104

Q9UI40

Ensembl transtripts involved in fusion geneENST00000331872, ENST00000417584, 
ENST00000311223, ENST00000491322, 
ENST00000339526, 
ENST00000341998, 
ENST00000286344, 
Fusion gene scores* DoF score11 X 10 X 4=4406 X 6 X 5=180
# samples 177
** MAII scorelog2(17/440*10)=-1.37196877738696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLUL [Title/Abstract] AND SLC24A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLUL

GO:0008283

cell proliferation

18662667

TgeneSLC24A2

GO:0034220

ion transmembrane transport

18166528


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE765952GLULchr1

182352479

-SLC24A2chr9

19509293

-
ChiTaRS3.1BE765994GLULchr1

182352482

-SLC24A2chr9

19509294

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000331872ENST00000341998GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-intronENST00000331872ENST00000286344GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-3UTRENST00000417584ENST00000341998GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-intronENST00000417584ENST00000286344GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-3UTRENST00000311223ENST00000341998GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-intronENST00000311223ENST00000286344GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-3UTRENST00000491322ENST00000341998GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-intronENST00000491322ENST00000286344GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-3UTRENST00000339526ENST00000341998GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-intronENST00000339526ENST00000286344GLULchr1

182352479

-SLC24A2chr9

19509293

-
intron-3UTRENST00000331872ENST00000341998GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-intronENST00000331872ENST00000286344GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-3UTRENST00000417584ENST00000341998GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-intronENST00000417584ENST00000286344GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-3UTRENST00000311223ENST00000341998GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-intronENST00000311223ENST00000286344GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-3UTRENST00000491322ENST00000341998GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-intronENST00000491322ENST00000286344GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-3UTRENST00000339526ENST00000341998GLULchr1

182352482

-SLC24A2chr9

19509294

-
intron-intronENST00000339526ENST00000286344GLULchr1

182352482

-SLC24A2chr9

19509294

-

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FusionProtFeatures for GLUL_SLC24A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLUL

P15104

SLC24A2

Q9UI40

This enzyme has 2 functions: it catalyzes the productionof glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA),the latter in a pyridoxal phosphate-independent manner (Bysimilarity). Essential for proliferation of fetal skinfibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}. Critical component of the visual transduction cascade,controlling the calcium concentration of outer segments duringlight and darkness. Light causes a rapid lowering of cytosolicfree calcium in the outer segment of both retinal rod and conephotoreceptors and the light-induced lowering of calcium is causedby extrusion via this protein which plays a key role in theprocess of light adaptation. Transports 1 Ca(2+) and 1 K(+) inexchange for 4 Na(+).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLUL_SLC24A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLUL_SLC24A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLUL_SLC24A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLULP15104DB00130L-GlutamineGlutamine synthetasesmall moleculeapproved|investigational|nutraceutical
HgeneGLULP15104DB00142Glutamic AcidGlutamine synthetasesmall moleculeapproved|nutraceutical

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RelatedDiseases for GLUL_SLC24A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLULC0036341Schizophrenia4PSYGENET
HgeneGLULC0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneGLULC0023904Liver Neoplasms, Experimental2CTD_human
HgeneGLULC0011570Mental Depression1PSYGENET
HgeneGLULC0011581Depressive disorder1PSYGENET
HgeneGLULC0019151Hepatic Encephalopathy1CTD_human
HgeneGLULC0028754Obesity1CTD_human
HgeneGLULC0033975Psychotic Disorders1PSYGENET
HgeneGLULC0236663Alcohol withdrawal syndrome1PSYGENET
HgeneGLULC0525045Mood Disorders1PSYGENET
HgeneGLULC0752109Brain Diseases, Metabolic, Inborn1CTD_human
HgeneGLULC1864910Glutamine deficiency, congenital1CTD_human;ORPHANET;UNIPROT
HgeneGLULC2239176Liver carcinoma1CTD_human