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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14770

FusionGeneSummary for GLUL_NDUFV1

check button Fusion gene summary
Fusion gene informationFusion gene name: GLUL_NDUFV1
Fusion gene ID: 14770
HgeneTgene
Gene symbol

GLUL

NDUFV1

Gene ID

2752

4723

Gene nameglutamate-ammonia ligaseNADH:ubiquinone oxidoreductase core subunit V1
SynonymsGLNS|GS|PIG43|PIG59CI-51K|CI51KD|UQOR1
Cytomap

1q25.3

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionglutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainm
Modification date2018052220180523
UniProtAcc

P15104

P49821

Ensembl transtripts involved in fusion geneENST00000331872, ENST00000417584, 
ENST00000311223, ENST00000491322, 
ENST00000339526, 		ENST00000322776, 
ENST00000532303, ENST00000529927, 
ENST00000415352, ENST00000526169, 
Fusion gene scores* DoF score11 X 10 X 4=44035 X 6 X 14=2940
# samples 1737
** MAII scorelog2(17/440*10)=-1.37196877738696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/2940*10)=-2.99021897920741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLUL [Title/Abstract] AND NDUFV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLUL

GO:0008283

cell proliferation

18662667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1XS-01AGLULchr1

182352029

-NDUFV1chr11

67375697

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000331872ENST00000322776GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000331872ENST00000532303GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000331872ENST00000529927GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000331872ENST00000415352GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000331872ENST00000526169GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000417584ENST00000322776GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000417584ENST00000532303GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000417584ENST00000529927GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000417584ENST00000415352GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000417584ENST00000526169GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000311223ENST00000322776GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000311223ENST00000532303GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000311223ENST00000529927GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000311223ENST00000415352GLULchr1

182352029

-NDUFV1chr11

67375697

+
intron-intronENST00000311223ENST00000526169GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000491322ENST00000322776GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000491322ENST00000532303GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000491322ENST00000529927GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000491322ENST00000415352GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000491322ENST00000526169GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000339526ENST00000322776GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000339526ENST00000532303GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000339526ENST00000529927GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000339526ENST00000415352GLULchr1

182352029

-NDUFV1chr11

67375697

+
5CDS-intronENST00000339526ENST00000526169GLULchr1

182352029

-NDUFV1chr11

67375697

+

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FusionProtFeatures for GLUL_NDUFV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLUL

P15104

NDUFV1

P49821

This enzyme has 2 functions: it catalyzes the productionof glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA),the latter in a pyridoxal phosphate-independent manner (Bysimilarity). Essential for proliferation of fetal skinfibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}. Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLUL_NDUFV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLUL_NDUFV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLULPLEKHF2, GLUL, NUDT18, ND5, UBE2I, PIAS1, PIAS2, CASP8AP2, HIPK3, PIAS3, HIPK1, UBC, PPARD, RBBP6, SKIL, RABEPK, NFKB1, CYP39A1, FAM129B, ZFAND2B, NME7, DMXL2, TCHP, UBAP2, ASPSCR1, MCM2, HSD17B10, ZNRF1, CRBN, EP300, EGFR, C1orf94, TBC1D22B, TRIM25NDUFV1EWSR1, ICT1, COPS5, NDUFS8, NDUFS3, NDUFS7, NDUFS2, NDUFV2, NDUFS1, NDUFA9, NDUFB6, NDUFB10, TCOF1, VPS29, TMEM189, RRM1, NOTCH2, STMN1, TIMM9, HNRNPR, PNP, ABCD3, MPST, TOR1AIP1, ILF3, ERGIC1, DNAJB11, CPT1A, HTRA2, PAICS, HSPA1L, PALLD, SDHA, RNASET2, ADRB2, NDUFA8, COX5A, EEF2, MRPL45, ANXA11, ATP1A1, ATP1B1, ATP5F1, ATP6V0D1, FH, MTCH1, NDUFA10, NDUFA2, NDUFB8, NDUFS4, POR, SLC9A3R2, TOMM40, TPI1, UQCRB, VDAC2, PDHA1, PHB2, PSMD7, SDHB, STXBP1, UQCRFS1, NPHP1, NDUFA12, NDUFS5, NDUFA11, NDUFA13, NDUFS6, OXCT1, NDUFV3, ND1, ND5, NDUFB4, TIMMDC1, VAPA, GOLT1B, FOXQ1, NDUFA4, C15orf48, OCIAD1, COQ2, PAK7, COX6B1, C7orf55, C6orf203, COA3, NDUFB11, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLUL_NDUFV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLULP15104DB00130L-GlutamineGlutamine synthetasesmall moleculeapproved|investigational|nutraceutical
HgeneGLULP15104DB00142Glutamic AcidGlutamine synthetasesmall moleculeapproved|nutraceutical

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RelatedDiseases for GLUL_NDUFV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLULC0036341Schizophrenia4PSYGENET
HgeneGLULC0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneGLULC0023904Liver Neoplasms, Experimental2CTD_human
HgeneGLULC0011570Mental Depression1PSYGENET
HgeneGLULC0011581Depressive disorder1PSYGENET
HgeneGLULC0019151Hepatic Encephalopathy1CTD_human
HgeneGLULC0028754Obesity1CTD_human
HgeneGLULC0033975Psychotic Disorders1PSYGENET
HgeneGLULC0236663Alcohol withdrawal syndrome1PSYGENET
HgeneGLULC0525045Mood Disorders1PSYGENET
HgeneGLULC0752109Brain Diseases, Metabolic, Inborn1CTD_human
HgeneGLULC1864910Glutamine deficiency, congenital1CTD_human;ORPHANET;UNIPROT
HgeneGLULC2239176Liver carcinoma1CTD_human
TgeneNDUFV1C1838979MITOCHONDRIAL COMPLEX I DEFICIENCY2CTD_human;UNIPROT
TgeneNDUFV1C0005586Bipolar Disorder1PSYGENET
TgeneNDUFV1C0023264Leigh Disease1CTD_human;ORPHANET;UNIPROT
TgeneNDUFV1C0029408Degenerative polyarthritis1CTD_human
TgeneNDUFV1C0036341Schizophrenia1PSYGENET
TgeneNDUFV1C0038356Stomach Neoplasms1CTD_human
TgeneNDUFV1C0041696Unipolar Depression1PSYGENET
TgeneNDUFV1C1269683Major Depressive Disorder1PSYGENET