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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14769

FusionGeneSummary for GLUL_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: GLUL_MBP
Fusion gene ID: 14769
HgeneTgene
Gene symbol

GLUL

MBP

Gene ID

2752

5553

Gene nameglutamate-ammonia ligaseproteoglycan 2, pro eosinophil major basic protein
SynonymsGLNS|GS|PIG43|PIG59BMPG|MBP|MBP1|proMBP
Cytomap

1q25.3

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionglutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthaseproliferation-inducing protein 43bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052220180519
UniProtAcc

P15104

P02686

Ensembl transtripts involved in fusion geneENST00000331872, ENST00000417584, 
ENST00000311223, ENST00000491322, 
ENST00000339526, 
ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score11 X 10 X 4=44026 X 20 X 3=1560
# samples 1727
** MAII scorelog2(17/440*10)=-1.37196877738696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLUL [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLUL

GO:0008283

cell proliferation

18662667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-5319-01AGLULchr1

182356266

-MBPchr18

74729011

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000331872ENST00000382582GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000355994GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397875GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397866GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397865GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000527041GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-intronENST00000331872ENST00000359645GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000528160GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397869GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000354542GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000526111GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000580402GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000579129GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000578193GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397863GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000397860GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000331872ENST00000487778GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000382582GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000355994GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397875GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397866GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397865GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000527041GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-intronENST00000417584ENST00000359645GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000528160GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397869GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000354542GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000526111GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000580402GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000579129GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000578193GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397863GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000397860GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000417584ENST00000487778GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000382582GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000355994GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397875GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397866GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397865GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000527041GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-intronENST00000311223ENST00000359645GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000528160GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397869GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000354542GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000526111GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000580402GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000579129GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000578193GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397863GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000397860GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000311223ENST00000487778GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000382582GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000355994GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397875GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397866GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397865GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000527041GLULchr1

182356266

-MBPchr18

74729011

-
intron-intronENST00000491322ENST00000359645GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000528160GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397869GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000354542GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000526111GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000580402GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000579129GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000578193GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397863GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000397860GLULchr1

182356266

-MBPchr18

74729011

-
intron-5UTRENST00000491322ENST00000487778GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000382582GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000355994GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397875GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397866GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397865GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000527041GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-intronENST00000339526ENST00000359645GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000528160GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397869GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000354542GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000526111GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000580402GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000579129GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000578193GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397863GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000397860GLULchr1

182356266

-MBPchr18

74729011

-
5CDS-5UTRENST00000339526ENST00000487778GLULchr1

182356266

-MBPchr18

74729011

-

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FusionProtFeatures for GLUL_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLUL

P15104

MBP

P02686

This enzyme has 2 functions: it catalyzes the productionof glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA),the latter in a pyridoxal phosphate-independent manner (Bysimilarity). Essential for proliferation of fetal skinfibroblasts. {ECO:0000250, ECO:0000269|PubMed:18662667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLUL_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLUL_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLULPLEKHF2, GLUL, NUDT18, ND5, UBE2I, PIAS1, PIAS2, CASP8AP2, HIPK3, PIAS3, HIPK1, UBC, PPARD, RBBP6, SKIL, RABEPK, NFKB1, CYP39A1, FAM129B, ZFAND2B, NME7, DMXL2, TCHP, UBAP2, ASPSCR1, MCM2, HSD17B10, ZNRF1, CRBN, EP300, EGFR, C1orf94, TBC1D22B, TRIM25MBPTRPM7, PRMT5, STK39, HLA-DRA, PLP1, TSSK6, IRAK4, PRKCA, PRKCI, PRKCZ, PPP2R5C, LIMK1, LIMK2, TBK1, IKBKE, STK3, APTX, ATN1, ATXN1, MAPK14, LRRK2, PRKDC, MAPK12, MAPK11, MAPK13, MAPK3, MAPK1, CDK1, CDK5, MAP3K5, TLK1, RPS6KA6, DDX58, MELK, CDK7, CDK8, CDK9, HIPK2, SQSTM1, PKN1, ULK1, PRKCB, MAP3K3, CTDSP1, ABL1, MUS81, RPS6KA5, MYH6, MAP3K1, MAPK8, CTDSPL, NLN, IDE, PTPRA, PRKCD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GLUL_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLULP15104DB00130L-GlutamineGlutamine synthetasesmall moleculeapproved|investigational|nutraceutical
HgeneGLULP15104DB00142Glutamic AcidGlutamine synthetasesmall moleculeapproved|nutraceutical

Top

RelatedDiseases for GLUL_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLULC0036341Schizophrenia4PSYGENET
HgeneGLULC0001973Alcoholic Intoxication, Chronic2PSYGENET
HgeneGLULC0023904Liver Neoplasms, Experimental2CTD_human
HgeneGLULC0011570Mental Depression1PSYGENET
HgeneGLULC0011581Depressive disorder1PSYGENET
HgeneGLULC0019151Hepatic Encephalopathy1CTD_human
HgeneGLULC0028754Obesity1CTD_human
HgeneGLULC0033975Psychotic Disorders1PSYGENET
HgeneGLULC0236663Alcohol withdrawal syndrome1PSYGENET
HgeneGLULC0525045Mood Disorders1PSYGENET
HgeneGLULC0752109Brain Diseases, Metabolic, Inborn1CTD_human
HgeneGLULC1864910Glutamine deficiency, congenital1CTD_human;ORPHANET;UNIPROT
HgeneGLULC2239176Liver carcinoma1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human