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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14749

FusionGeneSummary for GLS_MYO1B

check button Fusion gene summary
Fusion gene informationFusion gene name: GLS_MYO1B
Fusion gene ID: 14749
HgeneTgene
Gene symbol

GLS

MYO1B

Gene ID

27165

4430

Gene nameglutaminase 2myosin IB
SynonymsGA|GLS|LGA|hLGAMMI-alpha|MMIa|MYH-1c|myr1
Cytomap

12q13.3

2q32.3

Type of geneprotein-codingprotein-coding
Descriptionglutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminaseunconventional myosin-IbMYO1B variant proteinmyosin-I alpha
Modification date2018052320180522
UniProtAcc

O94925

O43795

Ensembl transtripts involved in fusion geneENST00000320717, ENST00000338435, 
ENST00000409626, ENST00000409428, 
ENST00000409215, ENST00000471443, 
ENST00000339514, ENST00000392318, 
ENST00000304164, ENST00000392316, 
ENST00000439065, ENST00000496992, 
Fusion gene scores* DoF score3 X 4 X 3=366 X 6 X 3=108
# samples 47
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLS [Title/Abstract] AND MYO1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BB-4227-01AGLSchr2

191789319

+MYO1Bchr2

192141613

+
TCGALDHNSCTCGA-RS-A6TO-01AGLSchr2

191766752

+MYO1Bchr2

192141613

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000320717ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-intronENST00000320717ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-intronENST00000320717ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-intronENST00000338435ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-intronENST00000338435ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409626ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409626ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409428ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409428ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409215ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000409215ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000339514GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000392318GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000304164GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000392316GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000471443ENST00000439065GLSchr2

191789319

+MYO1Bchr2

192141613

+
intron-intronENST00000471443ENST00000496992GLSchr2

191789319

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000320717ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-intronENST00000320717ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-intronENST00000320717ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-5UTRENST00000338435ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-intronENST00000338435ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
5CDS-intronENST00000338435ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409626ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409626ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409626ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409428ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409428ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409428ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000409215ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409215ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000409215ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000339514GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000392318GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000304164GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-5UTRENST00000471443ENST00000392316GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000471443ENST00000439065GLSchr2

191766752

+MYO1Bchr2

192141613

+
intron-intronENST00000471443ENST00000496992GLSchr2

191766752

+MYO1Bchr2

192141613

+

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FusionProtFeatures for GLS_MYO1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLS

O94925

MYO1B

O43795

Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity. Motor protein that may participate in process criticalto neuronal development and function such as cell migration,neurite outgrowth and vesicular transport. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLS_MYO1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLS_MYO1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLSSNTA1, CUL5, ATXN10, ATF2, CAPN1, EIF5A, GDA, GNS, MVD, MYL12A, PEPD, MRPL43, METTL20, C21orf33, NUFIP1, MRPL4, PPA2, ATF6B, HMGCL, ETFA, MRM1, RARS2, TNF, OXLD1, UNK, SIRT5, MCM2, SPATA20, COQ9, PTPMT1, CISD3, CCL22, NDUFS7, SNRNP27, CFAP45, TRMT61B, YBEY, OTC, ACAD9, FGB, LAMP3, ATCAYMYO1BEIF4A2, BRF2, MYC, SIRT7, TCF3, SP1, FBXO25, KIAA0368, CUL1, LRRK2, ATP6V1B1, ESR1, PAN2, RPA3, RPA2, RPA1, CUL7, CCDC8, EGFR, CSNK2A1, DAPK1, NTRK1, PTEN, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, STYXL1, NEXN, BCL7C, BCL7A, AVIL, LSP1, CDH5, DKK3, CYLD, DLST, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GLS_MYO1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLSO94925DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for GLS_MYO1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLSC0000786Spontaneous abortion1CTD_human
HgeneGLSC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGLSC0029408Degenerative polyarthritis1CTD_human
HgeneGLSC0036341Schizophrenia1PSYGENET
TgeneMYO1BC0043094Weight Gain1CTD_human