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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14748

FusionGeneSummary for GLS_ANKAR

check button Fusion gene summary
Fusion gene informationFusion gene name: GLS_ANKAR
Fusion gene ID: 14748
HgeneTgene
Gene symbol

GLS

ANKAR

Gene ID

27165

150709

Gene nameglutaminase 2ankyrin and armadillo repeat containing
SynonymsGA|GLS|LGA|hLGA-
Cytomap

12q13.3

2q32.2

Type of geneprotein-codingprotein-coding
Descriptionglutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminaseankyrin and armadillo repeat-containing protein
Modification date2018052320180522
UniProtAcc

O94925

Q7Z5J8

Ensembl transtripts involved in fusion geneENST00000320717, ENST00000338435, 
ENST00000409626, ENST00000409428, 
ENST00000409215, ENST00000471443, 
ENST00000520309, ENST00000313581, 
ENST00000281412, ENST00000438402, 
ENST00000431575, ENST00000461516, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: GLS [Title/Abstract] AND ANKAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AJ-A3BF-01AGLSchr2

191796363

+ANKARchr2

190609468

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000320717ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000320717ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000320717ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000320717ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000320717ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-intronENST00000320717ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000338435ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000338435ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000338435ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000338435ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000338435ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-intronENST00000338435ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409626ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409626ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409626ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409626ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409626ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-intronENST00000409626ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409428ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409428ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409428ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409428ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409428ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-intronENST00000409428ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409215ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
Frame-shitENST00000409215ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409215ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409215ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-3UTRENST00000409215ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
5CDS-intronENST00000409215ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-3CDSENST00000471443ENST00000520309GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-3CDSENST00000471443ENST00000313581GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-3UTRENST00000471443ENST00000281412GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-3UTRENST00000471443ENST00000438402GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-3UTRENST00000471443ENST00000431575GLSchr2

191796363

+ANKARchr2

190609468

+
3UTR-intronENST00000471443ENST00000461516GLSchr2

191796363

+ANKARchr2

190609468

+

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FusionProtFeatures for GLS_ANKAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLS

O94925

ANKAR

Q7Z5J8

Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLS_ANKAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLS_ANKAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLSSNTA1, CUL5, ATXN10, ATF2, CAPN1, EIF5A, GDA, GNS, MVD, MYL12A, PEPD, MRPL43, METTL20, C21orf33, NUFIP1, MRPL4, PPA2, ATF6B, HMGCL, ETFA, MRM1, RARS2, TNF, OXLD1, UNK, SIRT5, MCM2, SPATA20, COQ9, PTPMT1, CISD3, CCL22, NDUFS7, SNRNP27, CFAP45, TRMT61B, YBEY, OTC, ACAD9, FGB, LAMP3, ATCAYANKARIQCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLS_ANKAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLSO94925DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialsmall moleculeapproved|nutraceutical

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RelatedDiseases for GLS_ANKAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLSC0000786Spontaneous abortion1CTD_human
HgeneGLSC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGLSC0029408Degenerative polyarthritis1CTD_human
HgeneGLSC0036341Schizophrenia1PSYGENET