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Fusion gene ID: 14743 |
FusionGeneSummary for GLRX3_C10orf11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLRX3_C10orf11 | Fusion gene ID: 14743 | Hgene | Tgene | Gene symbol | GLRX3 | C10orf11 | Gene ID | 10539 |
| Gene name | glutaredoxin 3 | ||
| Synonyms | GLRX4|GRX3|GRX4|PICOT|TXNL2|TXNL3 | ||
| Cytomap | 10q26.3 | ||
| Type of gene | protein-coding | ||
| Description | glutaredoxin-3PKC-interacting cousin of thioredoxinPKC-theta-interacting proteinPKCq-interacting proteinglutaredoxin 4testicular tissue protein Li 75thioredoxin-like protein 2 | ||
| Modification date | 20180522 | ||
| UniProtAcc | O76003 | ||
| Ensembl transtripts involved in fusion gene | ENST00000331244, ENST00000368644, ENST00000496195, | ENST00000593699, ENST00000372499, ENST00000496424, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 17 X 6 X 7=714 |
| # samples | 3 | 19 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/714*10)=-1.90992465569815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GLRX3 [Title/Abstract] AND C10orf11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GLRX3 | GO:0044571 | [2Fe-2S] cluster assembly | 27519415 |
| Hgene | GLRX3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer | 27519415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A1FW-01A | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| TCGA | LD | BRCA | TCGA-A2-A1FW-01A | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000331244 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000331244 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000331244 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| intron-3UTR | ENST00000496195 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| intron-3UTR | ENST00000496195 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| intron-3UTR | ENST00000496195 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78084159 | + |
| 5CDS-3UTR | ENST00000331244 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| 5CDS-3UTR | ENST00000331244 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| 5CDS-3UTR | ENST00000331244 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| 5CDS-3UTR | ENST00000368644 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| intron-3UTR | ENST00000496195 | ENST00000593699 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| intron-3UTR | ENST00000496195 | ENST00000372499 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
| intron-3UTR | ENST00000496195 | ENST00000496424 | GLRX3 | chr10 | 131973353 | + | C10orf11 | chr10 | 78316967 | + |
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FusionProtFeatures for GLRX3_C10orf11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLRX3 | C10orf11 |
| Together with BOLA2, acts as a cytosolic iron-sulfur(Fe-S) cluster assembly factor that facilitates [2Fe-2S] clusterinsertion into a subset of cytosolic proteins (PubMed:26613676,PubMed:27519415). Acts as a critical negative regulator of cardiachypertrophy and a positive inotropic regulator (By similarity).Required for hemoglobin maturation (PubMed:23615448). Does notpossess any thyoredoxin activity since it lacks the conservedmotif that is essential for catalytic activity.{ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448,ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GLRX3_C10orf11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GLRX3_C10orf11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GLRX3 | NADK, KRTAP4-12, EFEMP2, ADAMTSL4, CIAPIN1, PLSCR1, RGS20, FRA10AC1, HEXDC, PRKCQ, MAPK6, FN1, VCAM1, ZNF512B, PRKD2, ITGA4, MMS19, GCLM, C12orf10, COASY, DCUN1D1, EFHD2, IDH1, RCN1, SUGT1, TSTA3, FAM96B, CIAO1, CBLB, GRN, KRTAP5-9, KRT31, MAP3K3, PCSK5, PFDN5, STAU1, TCF4, TRAF1, UGP2, ZNF148, CGGBP1, KRT38, IKZF1, GLRX3, MAPKBP1, MOXD1, ZNF544, ZBTB44, BOLA1, FAM118A, TRIM36, GMCL1, ZNF426, SOX7, KRTAP9-2, TMEM25, KRTAP4-7, KRTAP4-2, OLFM3, KRTAP13-1, ALKBH3, TRIM42, LCE2D, KRTAP10-9, KRTAP10-1, KRTAP10-11, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, KRTAP5-6, KRTAP4-11, KLRG2, API5, KHDRBS1, OSGEP, PDIA6, TBC1D23, ISYNA1, P4HB, TP53RK, NTRK1, EWSR1, ZNF23, DUSP9, RRM1, AHNAK2, SRC, NAA40, GNAZ, DNAAF1, TRIM25 | C10orf11 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLRX3_C10orf11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GLRX3_C10orf11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GLRX3 | C0018800 | Cardiomegaly | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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