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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14735

FusionGeneSummary for GLO1_CASC15

check button Fusion gene summary
Fusion gene informationFusion gene name: GLO1_CASC15
Fusion gene ID: 14735
HgeneTgene
Gene symbol

GLO1

CASC15

Gene ID

2739

401237

Gene nameglyoxalase Icancer susceptibility 15
SynonymsGLOD1|GLYI|HEL-S-74CANT|LINC00340|lnc-SOX4-1
Cytomap

6p21.2

6p22.3

Type of geneprotein-codingncRNA
Descriptionlactoylglutathione lyaseS-D-lactoylglutathione methylglyoxal lyasealdoketomutaseepididymis secretory protein Li 74glx Iglyoxalase domain containing 1ketone-aldehyde mutaselactoyl glutathione lyasemethylglyoxalasecancer susceptibility 15 (non-protein coding)cancer susceptibility candidate 15 (non-protein coding)long intergenic non-protein coding RNA 340
Modification date2018052720180517
UniProtAcc

Q04760

Ensembl transtripts involved in fusion geneENST00000373365, ENST00000470973, 
ENST00000605917, 
Fusion gene scores* DoF score4 X 3 X 4=486 X 6 X 3=108
# samples 57
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLO1 [Title/Abstract] AND CASC15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLO1

GO:0043066

negative regulation of apoptotic process

11489834


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-78-7155-01AGLO1chr6

38670747

-CASC15chr6

22214536

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373365ENST00000605917GLO1chr6

38670747

-CASC15chr6

22214536

+
intron-intronENST00000470973ENST00000605917GLO1chr6

38670747

-CASC15chr6

22214536

+

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FusionProtFeatures for GLO1_CASC15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLO1

Q04760

CASC15

Catalyzes the conversion of hemimercaptal, formed frommethylglyoxal and glutathione, to S-lactoylglutathione. Involvedin the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.{ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:23122816,ECO:0000269|PubMed:9705294}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLO1_CASC15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLO1_CASC15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLO1CPLX1, IGBP1, PNP, AGL, ITPA, IKBKG, MAP3K13, ASB12, MEOX2, CUL7, ACY1, AKR1B1, AKR1B15, ATIC, FABP5, ALDOA, ALDOC, GMPS, HSPB1, PGAM1, PRDX6, PREP, UMPS, GLOD4, GRHPR, HNRNPA1, HSD17B14, HSPE1, IMPA2, PGM3, PGP, PPA1, PSMG4, QDPR, STIP1, TKT, EWSR1, FOS, CDC25C, EYA4, SOD1, TRIM25CASC15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLO1_CASC15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLO1Q04760DB00328IndomethacinLactoylglutathione lyasesmall moleculeapproved|investigational
HgeneGLO1Q04760DB00143GlutathioneLactoylglutathione lyasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GLO1_CASC15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLO1C0011570Mental Depression2PSYGENET
HgeneGLO1C0011581Depressive disorder2CTD_human;PSYGENET
HgeneGLO1C0003469Anxiety Disorders1CTD_human
HgeneGLO1C0004352Autistic Disorder1CTD_human
HgeneGLO1C0005586Bipolar Disorder1PSYGENET
HgeneGLO1C0025202melanoma1CTD_human
HgeneGLO1C0036341Schizophrenia1PSYGENET
HgeneGLO1C0279626Squamous cell carcinoma of esophagus1CTD_human