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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14734

FusionGeneSummary for GLMN_FXYD5

check button Fusion gene summary
Fusion gene informationFusion gene name: GLMN_FXYD5
Fusion gene ID: 14734
HgeneTgene
Gene symbol

GLMN

FXYD5

Gene ID

11146

53827

Gene nameglomulin, FKBP associated proteinFXYD domain containing ion transport regulator 5
SynonymsFAP|FAP48|FAP68|FKBPAP|GLML|GVM|VMGLOMDYSAD|HSPC113|IWU1|KCT1|OIT2|PRO6241|RIC
Cytomap

1p22.1

19q13.12

Type of geneprotein-codingprotein-coding
DescriptionglomulinFK506-binding protein-associated proteinFKBP-associated proteinFXYD domain-containing ion transport regulator 5dysadherinkeratinocytes associated transmembrane protein 1
Modification date2018052320180523
UniProtAcc

Q92990

Q96DB9

Ensembl transtripts involved in fusion geneENST00000370360, ENST00000534881, 
ENST00000543307, ENST00000392219, 
ENST00000541435, ENST00000590686, 
ENST00000342879, ENST00000588699, 
ENST00000423817, ENST00000392218, 
ENST00000591716, ENST00000392217, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GLMN [Title/Abstract] AND FXYD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLMN

GO:0042130

negative regulation of T cell proliferation

12604780

HgeneGLMN

GO:0042327

positive regulation of phosphorylation

11571281


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV692154GLMNchr1

92726599

-FXYD5chr19

35660726

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370360ENST00000543307GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000392219GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000541435GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000590686GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000342879GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000588699GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000423817GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000370360ENST00000392218GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000591716GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000370360ENST00000392217GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000534881ENST00000543307GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000392219GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000541435GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000590686GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000342879GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000588699GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000423817GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-intronENST00000534881ENST00000392218GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000591716GLMNchr1

92726599

-FXYD5chr19

35660726

+
intron-3UTRENST00000534881ENST00000392217GLMNchr1

92726599

-FXYD5chr19

35660726

+

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FusionProtFeatures for GLMN_FXYD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLMN

Q92990

FXYD5

Q96DB9

Essential for normal development of the vasculature. Mayrepresent a naturally occurring ligand of the immunophilins FKBP59and FKBP12. May function as an membrane anchoring protein. Isoform1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cellproliferation and increase IL2 production.{ECO:0000269|PubMed:11571281, ECO:0000269|PubMed:12604780}. Involved in down-regulation of E-cadherin which resultsin reduced cell adhesion. Promotes metastasis.{ECO:0000269|PubMed:11756660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLMN_FXYD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLMN_FXYD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLMN_FXYD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLMN_FXYD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFXYD5C0023893Liver Cirrhosis, Experimental1CTD_human