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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14703

FusionGeneSummary for GLG1_NUMA1

check button Fusion gene summary
Fusion gene informationFusion gene name: GLG1_NUMA1
Fusion gene ID: 14703
HgeneTgene
Gene symbol

GLG1

NUMA1

Gene ID

2734

4926

Gene namegolgi glycoprotein 1nuclear mitotic apparatus protein 1
SynonymsCFR-1|ESL-1|MG-160|MG160NMP-22|NUMA
Cytomap

16q23.1

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionGolgi apparatus protein 1E-selectin ligand 1cysteine-rich fibroblast growth factor receptorgolgi sialoglycoprotein MG-160nuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear protein
Modification date2018052320180523
UniProtAcc

Q92896

Q14980

Ensembl transtripts involved in fusion geneENST00000205061, ENST00000422840, 
ENST00000447066, 
ENST00000351960, 
ENST00000358965, ENST00000393695, 
ENST00000543450, 
Fusion gene scores* DoF score10 X 10 X 9=9009 X 9 X 3=243
# samples 139
** MAII scorelog2(13/900*10)=-2.79141337818858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/243*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLG1 [Title/Abstract] AND NUMA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUMA1

GO:0000132

establishment of mitotic spindle orientation

21816348

TgeneNUMA1

GO:0030953

astral microtubule organization

12445386

TgeneNUMA1

GO:0060236

regulation of mitotic spindle organization

26195665

TgeneNUMA1

GO:1902365

positive regulation of protein localization to spindle pole body

16076287


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA446212GLG1chr16

74486977

+NUMA1chr11

71723464

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000205061ENST00000351960GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000205061ENST00000358965GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000205061ENST00000393695GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000205061ENST00000543450GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000422840ENST00000351960GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000422840ENST00000358965GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000422840ENST00000393695GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000422840ENST00000543450GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000447066ENST00000351960GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000447066ENST00000358965GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000447066ENST00000393695GLG1chr16

74486977

+NUMA1chr11

71723464

+
intron-intronENST00000447066ENST00000543450GLG1chr16

74486977

+NUMA1chr11

71723464

+

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FusionProtFeatures for GLG1_NUMA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLG1

Q92896

NUMA1

Q14980

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding ofneutrophils). Microtubule (MT)-binding protein that plays a role inthe formation and maintenance of the spindle poles and thealignement and the segregation of chromosomes during mitotic celldivision (PubMed:7769006, PubMed:17172455, PubMed:19255246,PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions totether the minus ends of MTs at the spindle poles, which iscritical for the establishment and maintenance of the spindlepoles (PubMed:12445386, PubMed:11956313). Plays a role in theestablishment of the mitotic spindle orientation during metaphaseand elongation during anaphase in a dynein-dynactin-dependentmanner (PubMed:23870127, PubMed:24109598, PubMed:24996901,PubMed:26765568). In metaphase, part of a ternary complex composedof GPSM2 and G(i) alpha proteins, that regulates the recruitmentand anchorage of the dynein-dynactin complex in the mitotic cellcortex regions situated above the two spindle poles, and henceregulates the correct oritentation of the mitotic spindle(PubMed:23027904, PubMed:22327364, PubMed:23921553). Duringanaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical regionthrough direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulationof the spindle elongation and chromosome segregation(PubMed:22327364, PubMed:23921553, PubMed:24996901,PubMed:24371089). Binds also to other polyanionicphosphoinositides, such as phosphatidylinositol 3-phosphate (PIP),lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate(PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also requiredfor proper orientation of the mitotic spindle during asymmetriccell divisions (PubMed:21816348). Plays a role in mitotic MT asterassembly (PubMed:11163243, PubMed:11229403, PubMed:12445386).Involved in anastral spindle assembly (PubMed:25657325).Positively regulates TNKS protein localization to spindle poles inmitosis (PubMed:16076287). Highly abundant component of thenuclear matrix where it may serve a non-mitotic structural role,occupies the majority of the nuclear volume (PubMed:10075938).Required for epidermal differentiation and hair folliclemorphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0,ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403,ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386,ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455,ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364,ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127,ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598,ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901,ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665,ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074,ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938,ECO:0000305|PubMed:21816348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLG1_NUMA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLG1_NUMA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLG1_NUMA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLG1_NUMA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUMA1C0162820Dermatitis, Allergic Contact1CTD_human