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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14689

FusionGeneSummary for GLCCI1_ICA1

check button Fusion gene summary
Fusion gene informationFusion gene name: GLCCI1_ICA1
Fusion gene ID: 14689
HgeneTgene
Gene symbol

GLCCI1

ICA1

Gene ID

113263

3382

Gene nameglucocorticoid induced 1islet cell autoantigen 1
SynonymsFAM117C|GCTR|GIG18|TSSN1ICA69|ICAp69
Cytomap

7p21.3

7p21.3

Type of geneprotein-codingprotein-coding
Descriptionglucocorticoid-induced transcript 1 proteinglucocorticoid induced transcript 1islet cell autoantigen 169 kDa islet cell autoantigendiabetes mellitus type I autoantigenislet cell autoantigen 1 isoformislet cell autoantigen 1, 69kDaislet cell autoantigen p69p69testicular tissue protein Li 162
Modification date2018052320180519
UniProtAcc

Q86VQ1

Q05084

Ensembl transtripts involved in fusion geneENST00000223145, ENST00000474269, 
ENST00000402384, ENST00000406470, 
ENST00000265577, ENST00000396675, 
ENST00000401396, ENST00000422063, 
ENST00000407906, ENST00000476942, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 3 X 4=48
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLCCI1 [Title/Abstract] AND ICA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-4Z-AA84-01AGLCCI1chr7

8110761

+ICA1chr7

8183602

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000223145ENST00000402384GLCCI1chr7

8110761

+ICA1chr7

8183602

-
Frame-shiftENST00000223145ENST00000406470GLCCI1chr7

8110761

+ICA1chr7

8183602

-
Frame-shiftENST00000223145ENST00000265577GLCCI1chr7

8110761

+ICA1chr7

8183602

-
Frame-shiftENST00000223145ENST00000396675GLCCI1chr7

8110761

+ICA1chr7

8183602

-
Frame-shiftENST00000223145ENST00000401396GLCCI1chr7

8110761

+ICA1chr7

8183602

-
Frame-shiftENST00000223145ENST00000422063GLCCI1chr7

8110761

+ICA1chr7

8183602

-
5CDS-intronENST00000223145ENST00000407906GLCCI1chr7

8110761

+ICA1chr7

8183602

-
5CDS-intronENST00000223145ENST00000476942GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000402384GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000406470GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000265577GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000396675GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000401396GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-3CDSENST00000474269ENST00000422063GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-intronENST00000474269ENST00000407906GLCCI1chr7

8110761

+ICA1chr7

8183602

-
intron-intronENST00000474269ENST00000476942GLCCI1chr7

8110761

+ICA1chr7

8183602

-

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FusionProtFeatures for GLCCI1_ICA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLCCI1

Q86VQ1

ICA1

Q05084

May play a role in neurotransmitter secretion.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GLCCI1_ICA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GLCCI1_ICA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GLCCI1DYRK1B, DYRK1A, HECW2, XPO1, DYNLL1, TRIM41, ERICH6, DCAF7ICA1STK16, CNTF, KRT33B, MKKS, EXOC5, RAB2A, CCDC28A, MBD3, ING5, RAB2B, PICK1, MORF4L1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GLCCI1_ICA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLCCI1_ICA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource