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Fusion gene ID: 14687 |
FusionGeneSummary for GLB1_SUSD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GLB1_SUSD5 | Fusion gene ID: 14687 | Hgene | Tgene | Gene symbol | GLB1 | SUSD5 | Gene ID | 2720 | 26032 |
| Gene name | galactosidase beta 1 | sushi domain containing 5 | |
| Synonyms | EBP|ELNR1|MPS4B | - | |
| Cytomap | 3p22.3 | 3p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-galactosidaseacid beta-galactosidaseelastin receptor 1, 67kDalactase | sushi domain-containing protein 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P16278 | O60279 | |
| Ensembl transtripts involved in fusion gene | ENST00000307363, ENST00000399402, ENST00000445488, ENST00000307377, ENST00000497796, | ENST00000309558, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GLB1 [Title/Abstract] AND SUSD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GLB1 | GO:0044262 | cellular carbohydrate metabolic process | 11927518 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-N8-A56S-01A | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000307363 | ENST00000309558 | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
| In-frame | ENST00000399402 | ENST00000309558 | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
| Frame-shift | ENST00000445488 | ENST00000309558 | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
| Frame-shift | ENST00000307377 | ENST00000309558 | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
| intron-3CDS | ENST00000497796 | ENST00000309558 | GLB1 | chr3 | 33087612 | - | SUSD5 | chr3 | 33216566 | - |
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FusionProtFeatures for GLB1_SUSD5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GLB1 | SUSD5 |
| Isoform 1: Cleaves beta-linked terminal galactosylresidues from gangliosides, glycoproteins, and glycosaminoglycans.{ECO:0000269|PubMed:15714521, ECO:0000269|PubMed:19472408,ECO:0000269|PubMed:2511208, ECO:0000269|PubMed:25936995,ECO:0000269|PubMed:8200356}. Isoform 2: Has no beta-galactosidase catalytic activity,but plays functional roles in the formation of extracellularelastic fibers (elastogenesis) and in the development ofconnective tissue. Seems to be identical to the elastin-bindingprotein (EBP), a major component of the non-integrin cell surfacereceptor expressed on fibroblasts, smooth muscle cells,chondroblasts, leukocytes, and certain cancer cell types. Inelastin producing cells, associates with tropoelastinintracellularly and functions as a recycling molecular chaperonewhich facilitates the secretions of tropoelastin and its assemblyinto elastic fibers. {ECO:0000269|PubMed:10841810,ECO:0000269|PubMed:8922281}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GLB1_SUSD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GLB1_ENST00000399402_chr3_33087612_-_SUSD5_ENST00000309558_chr3_33216566_-_819aa MFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVIL RPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHH LGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARG ASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKRSRVETRLRSHTPSCRAAPAWKWGMNCCTCVPQA TSWATGRPPSPCYVTAVGSGTAWCRPVGKMRLRHTLTMKITSLMTDLCHSESSWRIPGQRQMRTGVRETPLRRLQNRTVWSPFLWGEKTX PGIKSLCQPQACLVLGAVSPQIHQDHGCSRSTCSGFLLRLSTSLGWKRRWMMTPKSSFLLETTTVVXNWSQVNLKPRXSTATLMVPRGHL WARMTARQEIQWXAAVMSPGXMATLXQRGLGGRQRQKRKKMGTEGMGQXGWMKTSXLLLISPFLWKLRSPRVAPSHQARAXPIVQFFHLK CXMWKLWRSDPXMLPRLRALGMVTXRSTSQLYPGDSSQRNLPWPPCPMSSPAPPWRYXQXTLSSRHLTTSPQRSWQPPSLQXKPLFLRSR IASHTCCLKTSLDRKAPGQVQVRSFIPPWSRVWGTDVLASAEALXSPPLSPSCAYCCSWQVWGWCGATASASTRALCTSXMLASGRLGTT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GLB1_ENST00000399402_chr3_33087612_-_SUSD5_ENST00000309558_chr3_33216566_-_2459nt ATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTG CCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAG CCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTG AGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCC GACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTT ATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCAT CTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTG GACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTAT ACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGG GCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGC TACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGAGAAGCCGTGTG GAGACCCGCCTTCGTTCCCACACACCATCCTGCAGGGCCGCACCGGCTTGGAAATGGGGGATGAACTGCTGTACGTGTGTGCCCCAGGCC ACATCATGGGCCACCGGGAGACCGCCTTCACCTTGCTATGTAACAGCTGTGGGGAGTGGTACGGCCTGGTGCAGGCCTGTGGGAAAGATG AGGCTGAGGCACACATTGACTATGAAGATAACTTCCCTGATGACAGATCTGTGTCATTCAGAGAGCTCATGGAGGATTCCCGGACAGAGG CAGATGAGGACAGGGGTCAGGGAGACTCCTCTGAGGAGGCTCCAAAACAGGACCGTCTGGTCTCCATTTCTGTGGGGAGAGAAAACATAG CCCGGGATAAAGTCTTTGTGCCAACCACAGGCTTGCCTGGTGCTGGGAGCAGTGTCCCCGCAGATTCACCAGGATCACGGCTGCTCCAGA AGCACTTGTTCTGGTTTCCTGCTGAGGCTTTCCACAAGCCTGGGTTGGAAAAGGAGGTGGATGATGACACCAAAAAGCAGTTTTCTGCTG GAGACAACCACAGTGGTGTAAAATTGGTCCCAGGTGAACCTGAAACCAAGGTGATCTACGGCAACACTGATGGTCCCTCGGGGCCATTTG TGGGCAAGAATGACAGCAAGGCAGGAGATCCAGTGGTGAGCAGCAGTGATGAGTCCTGGTTAGATGGCTACCCTGTGACAGAGGGGGCTT GGAGGAAGACAGAGGCAGAAGAGGAAGAAGATGGGGACAGAGGGGATGGGTCAGTAGGGCTGGATGAAAACGTCCTAGTTACTCCTGATC AGCCCATTCTTGTGGAAGTTAAGAAGCCCAAGAGTAGCACCCTCACACCAAGCGAGGGCATGACCCATAGTTCAGTTCTTCCATCTCAAA TGCTAGATGTGGAAGCTTTGGCGCTCAGACCCGTGAATGCTTCCGAGACTGAGGGCATTGGGGATGGTGACTTGACGAAGTACCAGTCAA CTCTACCCTGGAGATTCATCACAGAGGAATCTCCCATGGCCACCCTGTCCTATGAGCTCACCAGCTCCACCCTGGAGATATTAACAGTGA ACACTGTCAAGCAGACACCTAACCACATCCCCTCAACGATCATGGCAACCACCCAGCCTCCAGTAGAAACCACTGTTCCTGAGATCCAGG ATAGCTTCCCATACCTGCTGTCTGAAGACTTCTTTGGACAGGAAGGCCCCGGGCCAGGTGCAAGTGAGGAGCTTCATCCCACCTTGGAGT CGTGTGTGGGGGACGGATGTCCTGGCCTCAGCAGAGGCCCTGTGATCGCCACCATTGTCACCGTCCTGTGCCTACTGCTGCTCCTGGCAG GTGTGGGGATGGTGTGGGGCTACCGCAAGTGCCAGCACAAGAGCTCTGTGTACAAGCTGAATGTTGGCCAGCGGCAGGCTCGGCACTACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GLB1_ENST00000399402_chr3_33087612_-_SUSD5_ENST00000309558_chr3_33216566_-_5288nt GGGCGGGCCGGGCGGGGCGCGCGTCCTTCCAGGCAGCTCGGTCGCTTGTGCGTTCCGCTCCGGCCGCCCTTTGCGCTTGGATCCACTTCC CCATCTGTAACGAGGTGTTGAGACGAGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAG CCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGG CTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATAT TTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCT GCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTG CCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGAT TTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACA TTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGG AAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACC GAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTAT TGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAG TATTTTGCTCTGCGAAACATCATCCAGAAGAGAAGCCGTGTGGAGACCCGCCTTCGTTCCCACACACCATCCTGCAGGGCCGCACCGGCT TGGAAATGGGGGATGAACTGCTGTACGTGTGTGCCCCAGGCCACATCATGGGCCACCGGGAGACCGCCTTCACCTTGCTATGTAACAGCT GTGGGGAGTGGTACGGCCTGGTGCAGGCCTGTGGGAAAGATGAGGCTGAGGCACACATTGACTATGAAGATAACTTCCCTGATGACAGAT CTGTGTCATTCAGAGAGCTCATGGAGGATTCCCGGACAGAGGCAGATGAGGACAGGGGTCAGGGAGACTCCTCTGAGGAGGCTCCAAAAC AGGACCGTCTGGTCTCCATTTCTGTGGGGAGAGAAAACATAGCCCGGGATAAAGTCTTTGTGCCAACCACAGGCTTGCCTGGTGCTGGGA GCAGTGTCCCCGCAGATTCACCAGGATCACGGCTGCTCCAGAAGCACTTGTTCTGGTTTCCTGCTGAGGCTTTCCACAAGCCTGGGTTGG AAAAGGAGGTGGATGATGACACCAAAAAGCAGTTTTCTGCTGGAGACAACCACAGTGGTGTAAAATTGGTCCCAGGTGAACCTGAAACCA AGGTGATCTACGGCAACACTGATGGTCCCTCGGGGCCATTTGTGGGCAAGAATGACAGCAAGGCAGGAGATCCAGTGGTGAGCAGCAGTG ATGAGTCCTGGTTAGATGGCTACCCTGTGACAGAGGGGGCTTGGAGGAAGACAGAGGCAGAAGAGGAAGAAGATGGGGACAGAGGGGATG GGTCAGTAGGGCTGGATGAAAACGTCCTAGTTACTCCTGATCAGCCCATTCTTGTGGAAGTTAAGAAGCCCAAGAGTAGCACCCTCACAC CAAGCGAGGGCATGACCCATAGTTCAGTTCTTCCATCTCAAATGCTAGATGTGGAAGCTTTGGCGCTCAGACCCGTGAATGCTTCCGAGA CTGAGGGCATTGGGGATGGTGACTTGACGAAGTACCAGTCAACTCTACCCTGGAGATTCATCACAGAGGAATCTCCCATGGCCACCCTGT CCTATGAGCTCACCAGCTCCACCCTGGAGATATTAACAGTGAACACTGTCAAGCAGACACCTAACCACATCCCCTCAACGATCATGGCAA CCACCCAGCCTCCAGTAGAAACCACTGTTCCTGAGATCCAGGATAGCTTCCCATACCTGCTGTCTGAAGACTTCTTTGGACAGGAAGGCC CCGGGCCAGGTGCAAGTGAGGAGCTTCATCCCACCTTGGAGTCGTGTGTGGGGGACGGATGTCCTGGCCTCAGCAGAGGCCCTGTGATCG CCACCATTGTCACCGTCCTGTGCCTACTGCTGCTCCTGGCAGGTGTGGGGATGGTGTGGGGCTACCGCAAGTGCCAGCACAAGAGCTCTG TGTACAAGCTGAATGTTGGCCAGCGGCAGGCTCGGCACTACCACCAGCAGATCGAGATGGAGAAGGTCTAGGCACCTTTGGAGTGGGTTC TCCCAAAGCCACTTGGGAGGAAAATAACTGTGACACATCACACGATAATTCACTAGAGCATGACGCAGGTGGACTGAGGCTCATCATTTT TTCCTCAGCCCTTTGTTTTATAGGCTGAGAAGTGTCTCTGGAGCACCTGGGAGGGCAGGGAGGCTTTGGTGACATCATCACTCATGTCAA TGTCTCCTCCACCATCTGCCCTGGAATTGACTACACTAATCCCAGACCTGTGCTTGGGCCCTGTTTCCAGTGTGAGGTCAAAAATCGCCT CTTCCTTCATCACAGTATTATCTTTTTTTTTTTGAGACAGAGTCTCATGCTGTTGCCCAGGCTGGAGTGCAGTGTCCCGATCTGAGCTCA CTGCAACCTCTGCCTCCCAAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGGTGGGATTACAGGCATGCACCACCATGCCCAGCT AATTTTTTTATATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGCTGGTCAAGAACTCCTGACCTCAAGTGATCTGCCCTCCTTA GCCTCCCAAAGTGCTAGGATTCCAGGTGTGAGCCACATCACAGTATTACCTTTTTGAAGAAAGAAAATCACCAGCTTCATGCCCTGAAAT TTTATAAATAGTCATGATAAACCAAGTGTATGAGAGCAGTATTATCTAGGACATGGATATTGAATTATTGGGAGAGGAATATGGAAGAAT AATGGGTTGTTTCCTTTTAATGTTGTGATGTTGCTGAGGGCAGATGAACCAAGAGCCAGGACACAGTCTAGAAGCTTTGAGGTTTCTTTT TTCATTGTTTCTTGAAATTAGAATTTAAGACTGACATTTTGTTGGGGGAGTTGAGGAGTGAAGAAACACACATCCCCCTCTGTTCCCTCC ATTCTGTGGGACAGTCTGTCATTTATTTTATTTTATTTTCAATATTTCATGGTTAAGGATTTGCCATTATTTTTTAAAAACAAAGTTAGC TTTGTACCAGTAAGTACCATTTCCTCTCAGAAGCAGTGGCCTAGTTGTCCTTGACCAGTCTGTGCCTAGGAATGTCTTGGAATTTTTGCC AGGACTAACAAAACTCAGTCCTTGGTTTCCTCTCTCAGGATTAACCATTTCTCTGAACTCCAGTAAGAGAGAATGACACGGGAGAAAAAA AAAAGAAATGTTTTCAGAGGGCCGAACACCAGGTTATCAAGTATGGGCACATACTTGATGGAGAAGCAGAAGAATCTGTGAAAGAATATG AAATGATCTGTGCTGATCTGTTCTCTAGTGTGGAAACTGGGAGCTCTGTGGAAACAGAATCCATCCTGTCTGTTGGGTAACCCATTTCGT AGCATCTAAATCATCTTAGGGTGGCTCAGCGAGGATGGTTTATGGCAGTGGTTCTCAAAGTGTGGTCCTCAGACCAGTAGCATCAGCGTC ACCTGGGAATTTGTTGGAGATGCAAATTCTCTAGTCCCACCCTGGACTCAGGAAACAGGAACCCTGGGAGTAGGGCCCAGTTCTGTTTTT AACAAGCCCTCCAGGTGATTTTGATATGCACTCAAGTTTGAGAGCCTGTTGGTTTATAATAATCTCAAATGTGAACTTCGAGGCCAGCTG AAGCCCTAAAGGCACAGATGAGTATGTGGTGTGTGTTGTGTGGAAGTCAGGCATGGCTGTGTGCAGCTGAGGTGGCATTTGAAGCTGCCT AAATGCCACCTGCAATAGTCTCCTGTATGTTGGCACAGAAATGAAACATGTTATATTTTTCTAATATGAATCACCTTCTTAGAAATAGTT ATCAGTGGTAAAAAGTGATGAATGCAACACATTTATTTTGAGACACCATAGCAGTCTAAGTGTTTTTGTGTGGTAGAGGGAAATCCTGAT CTTTTTTATGATTGAAAAATTGTTGGTGGTGTTTTACCTAAGGAAAAAAAACATTCGCAACATGTTTTCTACCCTGCCACCTCTTTTCAG CAAGCTTTGGAAAAGTAATAGGCGAAGTAGCTGTAAAGAGAGGCAGCATAATCAAAGATCTTATTCCCCATAGTTGGGTAAAATAAAGCC TGAAGGTACCAACTAGAATACCTGTGCATCAGACGAAGTCAAGAACAATAGGAATAAAATGCTTTCTGCATGTAGCCAAAGCAAAACATA ATAGAATAAAAGCCAGAGACTGTATATATTTATAAATTAGATCCTAATCTACTGCAAGATAACTTTTCTATTTTTAACTATATAAAATAA CCTCTGTCTCAGCATTGGGACTGTGTTAGCAACTATTATTGTGGAATAACCCAGAACATTGGATTTATACCAACAAATAGGCAATATTAA TACAGTGTATTAATAAATTTATTACAAATTATTAATACAGTGTATTAATAAATTTATTACAAATTATTAATACAGGTAAATGTTTTATTT GTAGACATGGACTGTGAAATAAACCCAACACATCAGTTTTTAAGTTCTTATTGGTGTGGTATCCTCTAAATTAATGTTATAGAATCTAAA AATTCATGTTGAAAGGGAATGATTAAAACAATGTAAATCTAAATTGTATGTCATGCATGTTTTGAGAATGGTGAATGTTTAATGCTCATG |
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FusionGenePPI for GLB1_SUSD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GLB1 | CTNNBIP1, NEU1, H2AFX, CSNK2B, TK1, PLK1, FBXO6, FOS, MEPCE, VCP, ABCE1, DNAJB2, DNAJB4, LGALS3, VAPA, ATP6AP2, C7orf43, TRAPPC10, TRAPPC9, TRAPPC6B, KLHDC9, TRAPPC1, TRAPPC4, TRAPPC3, TRAPPC2L, KHK, RHOC, SFXN5, FZR1, RHOA, DNAJB1, PLAUR, TRAPPC5, PVRL4, TRAPPC2, RORC, CDK2, PTPN7, YPEL5, CTSA, VIM, XPNPEP3 | SUSD5 | LGALS8, LGALS9, FCN1, DEFA5, SERPINA12, FAM19A4, AMZ1, IGFBP1, CD1E |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GLB1_SUSD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GLB1_SUSD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GLB1 | C0268271 | Gangliosidosis, Generalized GM1, Type 1 (disorder) | 23 | ORPHANET;UNIPROT |
| Hgene | GLB1 | C0268272 | Gangliosidosis, Generalized GM1, Type 2 | 14 | ORPHANET;UNIPROT |
| Hgene | GLB1 | C0086652 | Mucopolysaccharidosis type IVB | 13 | ORPHANET;UNIPROT |
| Hgene | GLB1 | C0268273 | Gangliosidosis, Generalized GM1, Type 3 | 13 | ORPHANET;UNIPROT |
| Hgene | GLB1 | C0026707 | Mucopolysaccharidosis IV | 2 | CTD_human |
| Hgene | GLB1 | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Hgene | GLB1 | C0010038 | Corneal Opacity | 1 | CTD_human |
| Hgene | GLB1 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Hgene | GLB1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | GLB1 | C0029422 | Osteochondrodysplasias | 1 | CTD_human |
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