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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14678

FusionGeneSummary for GK5_CENPL

check button Fusion gene summary
Fusion gene informationFusion gene name: GK5_CENPL
Fusion gene ID: 14678
HgeneTgene
Gene symbol

GK5

CENPL

Gene ID

256356

91687

Gene nameglycerol kinase 5centromere protein L
Synonyms-C1orf155|CENP-L|dJ383J4.3
Cytomap

3q23

1q25.1

Type of geneprotein-codingprotein-coding
Descriptionputative glycerol kinase 5ATP:glycerol 3-phosphotransferase 5GK 5glycerokinase 5glycerol kinase 5 (putative)centromere protein Linterphase centromere complex protein 33
Modification date2018052320180522
UniProtAcc

Q6ZS86

Q8N0S6

Ensembl transtripts involved in fusion geneENST00000392993, ENST00000544571, 
ENST00000466685, 
ENST00000356198, 
ENST00000345664, ENST00000367710, 
ENST00000495275, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 2 X 3=24
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GK5 [Title/Abstract] AND CENPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-PL-A8LZ-01AGK5chr3

141934441

-CENPLchr1

173780444

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000392993ENST00000356198GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-5UTRENST00000392993ENST00000345664GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-5UTRENST00000392993ENST00000367710GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-intronENST00000392993ENST00000495275GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-5UTRENST00000544571ENST00000356198GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-5UTRENST00000544571ENST00000345664GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-5UTRENST00000544571ENST00000367710GK5chr3

141934441

-CENPLchr1

173780444

-
5CDS-intronENST00000544571ENST00000495275GK5chr3

141934441

-CENPLchr1

173780444

-
5UTR-5UTRENST00000466685ENST00000356198GK5chr3

141934441

-CENPLchr1

173780444

-
5UTR-5UTRENST00000466685ENST00000345664GK5chr3

141934441

-CENPLchr1

173780444

-
5UTR-5UTRENST00000466685ENST00000367710GK5chr3

141934441

-CENPLchr1

173780444

-
5UTR-intronENST00000466685ENST00000495275GK5chr3

141934441

-CENPLchr1

173780444

-

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FusionProtFeatures for GK5_CENPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GK5

Q6ZS86

CENPL

Q8N0S6

Component of the CENPA-CAD (nucleosome distal) complex,a complex recruited to centromeres which is involved in assemblyof kinetochore proteins, mitotic progression and chromosomesegregation. May be involved in incorporation of newly synthesizedCENPA into centromeres via its interaction with the CENPA-NACcomplex. {ECO:0000269|PubMed:16716197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GK5_CENPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GK5_CENPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GK5ELAVL1CENPLELAVL1, CENPM, CENPN, CENPU, JMJD6, FAM9B, ICK, EGFR, SCN3B, RRP8, GORASP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GK5_CENPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GK5_CENPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource