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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14667

FusionGeneSummary for GIT1_MAGI1

check button Fusion gene summary
Fusion gene informationFusion gene name: GIT1_MAGI1
Fusion gene ID: 14667
HgeneTgene
Gene symbol

GIT1

MAGI1

Gene ID

28964

154043

Gene nameGIT ArfGAP 1CNKSR family member 3
Synonyms-CNK3|CNK3/IPCEF1|MAGI1
Cytomap

17q11.2

6q25.2

Type of geneprotein-codingprotein-coding
DescriptionARF GTPase-activating protein GIT1ARF GAP GIT1CAT-1CAT1G protein-coupled receptor kinase interacting ArfGAP 1G protein-coupled receptor kinase-interactor 1GRK-interacting protein 1cool-associated and tyrosine-phosphorylated protein 1connector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1
Modification date2018052220180522
UniProtAcc

Q9Y2X7

Q96QZ7

Ensembl transtripts involved in fusion geneENST00000225394, ENST00000394869, 
ENST00000581348, ENST00000579937, 
ENST00000330909, ENST00000402939, 
ENST00000483466, ENST00000497477, 
ENST00000470990, 
Fusion gene scores* DoF score2 X 2 X 1=411 X 11 X 2=242
# samples 312
** MAII scorelog2(3/4*10)=2.90689059560852log2(12/242*10)=-1.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GIT1 [Title/Abstract] AND MAGI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGIT1

GO:0032465

regulation of cytokinesis

23108400


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL110296GIT1chr17

27901181

-MAGI1chr3

65342493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000225394ENST00000330909GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000225394ENST00000402939GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000225394ENST00000483466GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000225394ENST00000497477GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000225394ENST00000470990GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000394869ENST00000330909GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000394869ENST00000402939GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000394869ENST00000483466GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000394869ENST00000497477GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000394869ENST00000470990GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000581348ENST00000330909GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000581348ENST00000402939GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000581348ENST00000483466GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000581348ENST00000497477GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000581348ENST00000470990GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000579937ENST00000330909GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-3UTRENST00000579937ENST00000402939GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000579937ENST00000483466GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000579937ENST00000497477GIT1chr17

27901181

-MAGI1chr3

65342493

-
intron-intronENST00000579937ENST00000470990GIT1chr17

27901181

-MAGI1chr3

65342493

-

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FusionProtFeatures for GIT1_MAGI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIT1

Q9Y2X7

MAGI1

Q96QZ7

GTPase-activating protein for the ADP ribosylationfactor family. May serve as a scaffold to bring together moleculesto form signaling modules controlling vesicle trafficking,adhesion and cytoskeletal organization. Increases the speed ofcell migration, as well as the size and rate of formation ofprotrusions, possibly by targeting PAK1 to adhesions and theleading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in theregulation of cytokinesis; the function may involve SDCCAG3 andPTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6,ECO:0000269|PubMed:11896197}. May play a role as scaffolding protein at cell-celljunctions. May regulate acid-induced ASIC3 currents by modulatingits expression at the cell surface (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GIT1_MAGI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GIT1_MAGI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GIT1_MAGI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GIT1_MAGI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGIT1C0025261Memory Disorders1CTD_human
HgeneGIT1C0424295Hyperactive behavior1CTD_human
HgeneGIT1C1263846Attention deficit hyperactivity disorder1CTD_human
TgeneMAGI1C0005586Bipolar Disorder2PSYGENET
TgeneMAGI1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneMAGI1C0036341Schizophrenia1PSYGENET
TgeneMAGI1C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET