FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14657

FusionGeneSummary for GIPC1_ANKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: GIPC1_ANKZF1
Fusion gene ID: 14657
HgeneTgene
Gene symbol

GIPC1

ANKZF1

Gene ID

10755

55139

Gene nameGIPC PDZ domain containing family member 1ankyrin repeat and zinc finger domain containing 1
SynonymsC19orf3|GIPC|GLUT1CBP|Hs.6454|IIP-1|NIP|RGS19IP1|SEMCAP|SYNECTIIN|SYNECTIN|TIP-2ZNF744
Cytomap

19p13.12

2q35

Type of geneprotein-codingprotein-coding
DescriptionPDZ domain-containing protein GIPC1GAIP C-terminus-interacting proteinGLUT1 C-terminal binding proteinIGF-1 receptor interacting protein 1RGS-GAIP-interacting proteinRGS19-interacting protein 1regulator of G-protein signalling 19 interacting proteinankyrin repeat and zinc finger domain-containing protein 1zinc finger protein 744
Modification date2018052220180523
UniProtAcc

O14908

Q9H8Y5

Ensembl transtripts involved in fusion geneENST00000393029, ENST00000393028, 
ENST00000345425, ENST00000393033, 
ENST00000591349, ENST00000586027, 
ENST00000323348, ENST00000409849, 
ENST00000410034, 
Fusion gene scores* DoF score6 X 4 X 4=962 X 2 X 1=4
# samples 62
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: GIPC1 [Title/Abstract] AND ANKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA368878GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000393029ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393029ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393029ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-3CDSENST00000393028ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393028ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393028ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-3CDSENST00000345425ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000345425ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000345425ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-3CDSENST00000393033ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393033ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000393033ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-3CDSENST00000591349ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000591349ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000591349ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-3CDSENST00000586027ENST00000323348GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000586027ENST00000409849GIPC1chr19

14593668

-ANKZF1chr2

220096694

+
intron-intronENST00000586027ENST00000410034GIPC1chr19

14593668

-ANKZF1chr2

220096694

+

Top

FusionProtFeatures for GIPC1_ANKZF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIPC1

O14908

ANKZF1

Q9H8Y5

May be involved in G protein-linked signaling. Plays a role in the cellular response to hydrogenperoxide and in the maintenance of mitochondrial integrity underconditions of cellular stress (PubMed:28302725). Involved in theendoplasmic reticulum (ER)-associated degradation (ERAD) pathway(By similarity). {ECO:0000250, ECO:0000269|PubMed:28302725}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GIPC1_ANKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GIPC1_ANKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GIPC1_ANKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GIPC1_ANKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource