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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 14633

FusionGeneSummary for GIGYF2_EFHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: GIGYF2_EFHD1
Fusion gene ID: 14633
HgeneTgene
Gene symbol

GIGYF2

EFHD1

Gene ID

26058

80303

Gene nameGRB10 interacting GYF protein 2EF-hand domain family member D1
SynonymsGYF2|PARK11|PERQ2|PERQ3|TNRC15MST133|MSTP133|PP3051|SWS2
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionGRB10-interacting GYF protein 2PERQ amino acid rich, with GYF domain 3PERQ amino acid-rich with GYF domain-containing protein 2Parkinson disease (autosomal recessive, early onset) 11trinucleotide repeat-containing gene 15 proteinEF-hand domain-containing protein D1EF-hand domain-containing protein 1swiprosin-2
Modification date2018052220180519
UniProtAcc

Q6Y7W6

Q9BUP0

Ensembl transtripts involved in fusion geneENST00000373566, ENST00000373563, 
ENST00000409480, ENST00000409547, 
ENST00000409196, ENST00000409451, 
ENST00000482666, ENST00000452341, 
ENST00000409613, ENST00000264059, 
ENST00000409708, ENST00000410095, 
Fusion gene scores* DoF score18 X 17 X 13=39783 X 4 X 6=72
# samples 247
** MAII scorelog2(24/3978*10)=-4.05093696522523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GIGYF2 [Title/Abstract] AND EFHD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGIGYF2

GO:0016441

posttranscriptional gene silencing

27157137

HgeneGIGYF2

GO:0061157

mRNA destabilization

27157137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A07U-01AGIGYF2chr2

233599948

+EFHD1chr2

233527512

+
TCGARVBRCATCGA-B6-A0IJ-01AGIGYF2chr2

233613792

+EFHD1chr2

233537019

+
TCGARVLUSCTCGA-94-8491-01AGIGYF2chr2

233562102

+EFHD1chr2

233546295

+
TCGARVUCSTCGA-N8-A56S-01AGIGYF2chr2

233589401

+EFHD1chr2

233546295

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373566ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000373566ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000373566ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000373566ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000373563ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000373563ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000373563ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000373563ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409480ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409480ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409480ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409480ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409547ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409547ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409547ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409547ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409196ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409196ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409196ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409196ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409451ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000409451ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409451ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
5CDS-5UTRENST00000409451ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
3UTR-3CDSENST00000482666ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
3UTR-3CDSENST00000482666ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
3UTR-5UTRENST00000482666ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
3UTR-5UTRENST00000482666ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
intron-3CDSENST00000452341ENST00000409613GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
intron-3CDSENST00000452341ENST00000264059GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
intron-5UTRENST00000452341ENST00000409708GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
intron-5UTRENST00000452341ENST00000410095GIGYF2chr2

233599948

+EFHD1chr2

233527512

+
In-frameENST00000373566ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373566ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373566ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373566ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373563ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373563ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373563ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000373563ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409480ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409480ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409480ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409480ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409547ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409547ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409547ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409547ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409196ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409196ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409196ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409196ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409451ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409451ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409451ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
In-frameENST00000409451ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000482666ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000482666ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000482666ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000482666ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000452341ENST00000409613GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000452341ENST00000264059GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000452341ENST00000409708GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
intron-3CDSENST00000452341ENST00000410095GIGYF2chr2

233613792

+EFHD1chr2

233537019

+
5UTR-3CDSENST00000373566ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373566ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373566ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373566ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373563ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373563ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373563ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000373563ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409480ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409480ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409480ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409480ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409547ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409547ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409547ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409547ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409196ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409196ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409196ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409196ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409451ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409451ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409451ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
5UTR-3CDSENST00000409451ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000409613GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000264059GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000409708GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000410095GIGYF2chr2

233562102

+EFHD1chr2

233546295

+
intron-3CDSENST00000373566ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373566ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373566ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373566ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373563ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373563ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373563ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000373563ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409480ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409480ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409480ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409480ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409547ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409547ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409547ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409547ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409196ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409196ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409196ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409196ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409451ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409451ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409451ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000409451ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
3UTR-3CDSENST00000482666ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000409613GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000264059GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000409708GIGYF2chr2

233589401

+EFHD1chr2

233546295

+
intron-3CDSENST00000452341ENST00000410095GIGYF2chr2

233589401

+EFHD1chr2

233546295

+

Top

FusionProtFeatures for GIGYF2_EFHD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GIGYF2

Q6Y7W6

EFHD1

Q9BUP0

Acts as a calcium sensor for mitochondrial flash(mitoflash) activation, an event characterized by stochasticbursts of superoxide production (PubMed:26975899). May play a rolein neuronal differentiation (By similarity).{ECO:0000250|UniProtKB:Q9D4J1, ECO:0000269|PubMed:26975899}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+52940_50891300Motif4EHP-binding motif
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+63140_50891321Motif4EHP-binding motif
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+73140_50891300Motif4EHP-binding motif
TgeneEFHD1chr2:233599948chr2:233527512ENST00000264059+04103_114100240Calcium binding1
TgeneEFHD1chr2:233599948chr2:233527512ENST00000264059+04139_150100240Calcium binding2
TgeneEFHD1chr2:233599948chr2:233527512ENST00000409613+04103_1144144Calcium binding1
TgeneEFHD1chr2:233599948chr2:233527512ENST00000409613+04139_1504144Calcium binding2
TgeneEFHD1chr2:233613792chr2:233537019ENST00000409613+14103_11454144Calcium binding1
TgeneEFHD1chr2:233613792chr2:233537019ENST00000409613+14139_15054144Calcium binding2
TgeneEFHD1chr2:233599948chr2:233527512ENST00000264059+04126_161100240DomainEF-hand 2
TgeneEFHD1chr2:233599948chr2:233527512ENST00000409613+04126_1614144DomainEF-hand 2
TgeneEFHD1chr2:233599948chr2:233527512ENST00000409613+0490_1254144DomainEF-hand 1
TgeneEFHD1chr2:233613792chr2:233537019ENST00000409613+14126_16154144DomainEF-hand 2
TgeneEFHD1chr2:233613792chr2:233537019ENST00000409613+1490_12554144DomainEF-hand 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329106_111131300Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329118_272131300Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+3291198_1252131300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329436_473131300Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329607_1025131300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329738_888131300Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431106_111131321Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431118_272131321Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+4311198_1252131321Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431436_473131321Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431607_1025131321Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431738_888131321Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531106_111131300Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531118_272131300Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+5311198_1252131300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531436_473131300Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531607_1025131300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531738_888131300Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529106_111891300Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529118_272891300Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+5291198_1252891300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529436_473891300Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529607_1025891300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529738_888891300Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631106_111891321Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631118_272891321Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+6311198_1252891321Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631436_473891321Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631607_1025891321Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631738_888891321Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731106_111891300Compositional biasNote=Poly-Gly
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731118_272891300Compositional biasNote=Arg-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+7311198_1252891300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731436_473891300Compositional biasNote=Pro-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731607_1025891300Compositional biasNote=Gln-rich
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731738_888891300Compositional biasNote=Glu-rich
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329533_581131300DomainGYF
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431533_581131321DomainGYF
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531533_581131300DomainGYF
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529533_581891300DomainGYF
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631533_581891321DomainGYF
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731533_581891300DomainGYF
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+32940_50131300Motif4EHP-binding motif
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+43140_50131321Motif4EHP-binding motif
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+53140_50131300Motif4EHP-binding motif
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000373563+329547_563131300RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409451+431547_563131321RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233599948chr2:233527512ENST00000409547+531547_563131300RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000373563+529547_563891300RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409451+631547_563891321RegionRequired for GRB10-binding
HgeneGIGYF2chr2:233613792chr2:233537019ENST00000409547+731547_563891300RegionRequired for GRB10-binding
TgeneEFHD1chr2:233613792chr2:233537019ENST00000264059+14103_114150240Calcium binding1
TgeneEFHD1chr2:233613792chr2:233537019ENST00000264059+14139_150150240Calcium binding2
TgeneEFHD1chr2:233599948chr2:233527512ENST00000264059+0490_125100240DomainEF-hand 1
TgeneEFHD1chr2:233613792chr2:233537019ENST00000264059+14126_161150240DomainEF-hand 2
TgeneEFHD1chr2:233613792chr2:233537019ENST00000264059+1490_125150240DomainEF-hand 1


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FusionGeneSequence for GIGYF2_EFHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GIGYF2_EFHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GIGYF2GRB10, USP11, PRPF6, PRPF8, DDX20, SMN1, GEMIN4, U2AF2, U2AF1L4, SF3B2, ATN1, ELAVL1, YBX1, PABPC1, TNRC6B, FXR1, AGO2, G3BP1, CAPRIN1, APC, PCK1, SIRT7, DIS3L, HSP90AA1, EIF4E2, ZNF598, RQCD1, TARDBP, YWHAB, LGR4, AIRE, AURKB, CDKN1A, CEP250, CEP57, CEP76, EMD, LGALS3BP, MAGED2, TP53, TUBGCP3, VCP, HUWE1, CCDC8, BMI1, EXOSC7, WDR83, NTRK1, NINL, XPO1, RFX5, MCM2, MEX3C, CDH1, EGFR, MRPL12, C10orf88, NCAPH2, KCTD3, CGN, KIF13B, ZBTB21, KSR1, GIGYF1, RTKN, RALGPS2, MAST3, LRFN1, DENND1A, PPM1H, DENND4C, CDC25C, SH3PXD2A, SRGAP2, NF1, CBY1, LPIN3, SIPA1L1, CAMSAP2, HDAC4, NADK, LIMA1, MAGI1, TESK2, DCLK1, RASAL2, ZNF638, SH3RF3, OSBPL6, KIAA1804, MAPKAP1, TIAM1, KIF1C, PLEKHA7, PHLDB2, TANC2, PTPN13, NAV1, INPP5E, TRIM25EFHD1PGRMC1, TCHH, KRT33B, PSEN1, PAN2, LUZP4, FSD1, CHCHD10, MAS1, CPLX4, FOXP2, DUSP10, PPIAL4G, S100A8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GIGYF2_EFHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GIGYF2_EFHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGIGYF2C4083045PARKINSON DISEASE 11, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO1CTD_human;UNIPROT
TgeneEFHD1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneEFHD1C0036095Salivary Gland Neoplasms1CTD_human