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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14623

FusionGeneSummary for GID8_LSG1

check button Fusion gene summary
Fusion gene informationFusion gene name: GID8_LSG1
Fusion gene ID: 14623
HgeneTgene
Gene symbol

GID8

LSG1

Gene ID

54994

55341

Gene nameGID complex subunit 8 homologlarge 60S subunit nuclear export GTPase 1
SynonymsC20orf11|TWA1-
Cytomap

20q13.33

3q29

Type of geneprotein-codingprotein-coding
Descriptionglucose-induced degradation protein 8 homologprotein C20orf11two hybrid associated protein No. 1 with RanBPMtwo hybrid-associated protein 1 with RanBPMlarge subunit GTPase 1 homologhLsg1
Modification date2018051920180526
UniProtAcc

Q9NWU2

Q9H089

Ensembl transtripts involved in fusion geneENST00000266069, ENST00000497101, 
ENST00000265245, ENST00000480853, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: GID8 [Title/Abstract] AND LSG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLSG1

GO:0051168

nuclear export

16209721


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE645772GID8chr20

61576826

-LSG1chr3

194372939

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000266069ENST00000265245GID8chr20

61576826

-LSG1chr3

194372939

+
3UTR-intronENST00000266069ENST00000480853GID8chr20

61576826

-LSG1chr3

194372939

+
intron-intronENST00000497101ENST00000265245GID8chr20

61576826

-LSG1chr3

194372939

+
intron-intronENST00000497101ENST00000480853GID8chr20

61576826

-LSG1chr3

194372939

+

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FusionProtFeatures for GID8_LSG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GID8

Q9NWU2

LSG1

Q9H089

Acts as a positive regulator of Wnt signaling pathway bypromoting beta-catenin (CTNNB1) nuclear accumulation.{ECO:0000269|PubMed:28829046}. GTPase required for the XPO1/CRM1-mediated nuclearexport of the 60S ribosomal subunit. Probably acts by mediatingthe release of NMD3 from the 60S ribosomal subunit after exportinto the cytoplasm (Probable). {ECO:0000305|PubMed:16209721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GID8_LSG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GID8_LSG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GID8_LSG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GID8_LSG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource