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Fusion gene ID: 14607 |
FusionGeneSummary for GGT1_PRODH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GGT1_PRODH | Fusion gene ID: 14607 | Hgene | Tgene | Gene symbol | GGT1 | PRODH | Gene ID | 2678 | 5625 |
| Gene name | gamma-glutamyltransferase 1 | proline dehydrogenase 1 | |
| Synonyms | CD224|D22S672|D22S732|GGT|GGT 1|GTG | HSPOX2|PIG6|POX|PRODH1|PRODH2|TP53I6 | |
| Cytomap | 22q11.23 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutathione hydrolase 1 proenzymegamma-glutamyltranspeptidase 1glutathione hydrolase 1leukotriene-C4 hydrolasetesticular tissue protein Li 73 | proline dehydrogenase 1, mitochondrialp53-induced gene 6 proteinproline dehydrogenase (oxidase) 1proline oxidase 2proline oxidase, mitochondrialtumor protein p53 inducible protein 6 | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | P19440 | O43272 | |
| Ensembl transtripts involved in fusion gene | ENST00000248923, ENST00000400382, ENST00000400383, ENST00000400380, ENST00000406383, ENST00000466310, ENST00000401885, ENST00000404532, ENST00000403838, ENST00000404223, ENST00000404920, | ENST00000420436, ENST00000334029, ENST00000357068, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 5=100 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GGT1 [Title/Abstract] AND PRODH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GGT1 | GO:0006520 | cellular amino acid metabolic process | 14754911 |
| Hgene | GGT1 | GO:0006536 | glutamate metabolic process | 24047895 |
| Hgene | GGT1 | GO:0006631 | fatty acid metabolic process | 21447318 |
| Hgene | GGT1 | GO:0006751 | glutathione catabolic process | 17924658|21447318 |
| Hgene | GGT1 | GO:0031638 | zymogen activation | 23682772 |
| Hgene | GGT1 | GO:1901750 | leukotriene D4 biosynthetic process | 21447318 |
| Tgene | PRODH | GO:0010942 | positive regulation of cell death | 23743200 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J4-AATZ-01A | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000248923 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000248923 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000248923 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000400382 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400382 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400382 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000400383 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400383 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400383 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000400380 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400380 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000400380 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000406383 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000406383 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000406383 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000466310 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000466310 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000466310 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000401885 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000401885 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000401885 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000404532 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404532 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404532 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000403838 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000403838 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000403838 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000404223 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404223 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404223 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-intron | ENST00000404920 | ENST00000420436 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404920 | ENST00000334029 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
| intron-5UTR | ENST00000404920 | ENST00000357068 | GGT1 | chr22 | 24990853 | + | PRODH | chr22 | 18918711 | - |
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FusionProtFeatures for GGT1_PRODH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GGT1 | PRODH |
| Cleaves the gamma-glutamyl bond of extracellularglutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and othergamma-glutamyl compounds. The metabolism of glutathione releasesfree glutamate and the dipeptide cysteinyl-glycine, which ishydrolyzed to cysteine and glycine by dipeptidases. In thepresence of high concentrations of dipeptides and some aminoacids, can also catalyze a transpeptidation reaction, transferringthe gamma-glutamyl moiety to an acceptor amino acid to form a newgamma-glutamyl compound. Initiates extracellular glutathione (GSH)breakdown, provides cells with a local cysteine supply andcontributes to maintain intracellular GSH level. It is part of thecell antioxidant defense mechanism. Isoform 3 seems to beinactive. {ECO:0000269|PubMed:20622017,ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200,ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045,ECO:0000269|PubMed:8827453}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GGT1_PRODH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GGT1_PRODH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GGT1 | NAMPT, GGT1, CD53, CD81, CD82, GGT2, GYG1, CANX | PRODH | CAPN11, SLC23A3, BRAP, HSPA8, HSPA6, HSPA2, TUBA4A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GGT1_PRODH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GGT1 | P19440 | DB00143 | Glutathione | Glutathione hydrolase 1 proenzyme | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GGT1_PRODH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GGT1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
| Hgene | GGT1 | C0023895 | Liver diseases | 1 | CTD_human |
| Hgene | GGT1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | GGT1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | GGT1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
| Hgene | GGT1 | C0031099 | Periodontitis | 1 | CTD_human |
| Hgene | GGT1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | PRODH | C0268529 | Proline dehydrogenase deficiency | 5 | CTD_human;ORPHANET;UNIPROT |
| Tgene | PRODH | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | PRODH | C1833247 | SCHIZOPHRENIA 4 (disorder) | 2 | UNIPROT |
| Tgene | PRODH | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
| Tgene | PRODH | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | PRODH | C0027765 | nervous system disorder | 1 | CTD_human |
| Tgene | PRODH | C0036341 | Schizophrenia | 1 | CTD_human |
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