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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14603

FusionGeneSummary for GGNBP2_ZMAT4

check button Fusion gene summary
Fusion gene informationFusion gene name: GGNBP2_ZMAT4
Fusion gene ID: 14603
HgeneTgene
Gene symbol

GGNBP2

ZMAT4

Gene ID

79893

79698

Gene namegametogenetin binding protein 2zinc finger matrin-type 4
SynonymsDIF-3|DIF3|LCRG1|LZK1|ZFP403|ZNF403-
Cytomap

17q12

8p11.21

Type of geneprotein-codingprotein-coding
Descriptiongametogenetin-binding protein 2C3HC4-type zinc finger proteinlaryngeal carcinoma related gene 1laryngeal carcinoma-related protein 1zinc finger protein 403zinc finger matrin-type protein 4
Modification date2018052320180519
UniProtAcc

Q9H3C7

Q9H898

Ensembl transtripts involved in fusion geneENST00000304718, ENST00000485685, 
ENST00000315769, ENST00000297737, 
ENST00000523823, 
Fusion gene scores* DoF score5 X 5 X 5=12511 X 7 X 7=539
# samples 512
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GGNBP2 [Title/Abstract] AND ZMAT4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GD-A2C5-01AGGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000304718ENST00000315769GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
Frame-shiftENST00000304718ENST00000297737GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
5CDS-intronENST00000304718ENST00000523823GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
intron-3CDSENST00000485685ENST00000315769GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
intron-3CDSENST00000485685ENST00000297737GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-
intron-intronENST00000485685ENST00000523823GGNBP2chr17

34913176

+ZMAT4chr8

40554920

-

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FusionProtFeatures for GGNBP2_ZMAT4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GGNBP2

Q9H3C7

ZMAT4

Q9H898

May be involved in spermatogenesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GGNBP2_ZMAT4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GGNBP2_ZMAT4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GGNBP2FBXW11, PAK4, BTRC, CNOT11, ZNF331ZMAT4APP, SRPK2, HECW2, CUL3, FAM26D, DSG4, HEPHL1, LYG2, S100A3, VSIG8, NEU2, TRIM29, LRRC15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GGNBP2_ZMAT4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GGNBP2_ZMAT4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource