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Fusion gene ID: 14600 |
FusionGeneSummary for GGNBP2_NEBL |
Fusion gene summary |
Fusion gene information | Fusion gene name: GGNBP2_NEBL | Fusion gene ID: 14600 | Hgene | Tgene | Gene symbol | GGNBP2 | NEBL | Gene ID | 79893 | 10529 |
Gene name | gametogenetin binding protein 2 | nebulette | |
Synonyms | DIF-3|DIF3|LCRG1|LZK1|ZFP403|ZNF403 | LASP2|LNEBL | |
Cytomap | 17q12 | 10p12.31 | |
Type of gene | protein-coding | protein-coding | |
Description | gametogenetin-binding protein 2C3HC4-type zinc finger proteinlaryngeal carcinoma related gene 1laryngeal carcinoma-related protein 1zinc finger protein 403 | nebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H3C7 | O76041 | |
Ensembl transtripts involved in fusion gene | ENST00000304718, ENST00000485685, | ENST00000377122, ENST00000417816, ENST00000377159, ENST00000377119, ENST00000464278, | |
Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 5 X 4 X 4=80 |
# samples | 5 | 5 | |
** MAII score | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GGNBP2 [Title/Abstract] AND NEBL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-C5-A3HD-01B | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000304718 | ENST00000377122 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
In-frame | ENST00000304718 | ENST00000417816 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
In-frame | ENST00000304718 | ENST00000377159 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
5CDS-intron | ENST00000304718 | ENST00000377119 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
5CDS-intron | ENST00000304718 | ENST00000464278 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
Frame-shift | ENST00000485685 | ENST00000377122 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
Frame-shift | ENST00000485685 | ENST00000417816 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
Frame-shift | ENST00000485685 | ENST00000377159 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
5CDS-intron | ENST00000485685 | ENST00000377119 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
5CDS-intron | ENST00000485685 | ENST00000464278 | GGNBP2 | chr17 | 34901666 | + | NEBL | chr10 | 21101869 | - |
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FusionProtFeatures for GGNBP2_NEBL |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GGNBP2 | NEBL |
May be involved in spermatogenesis. | Binds to actin and plays an important role in theassembly of the Z-disk. May functionally link sarcomeric actin tothe desmin intermediate filaments in the heart muscle sarcomeres(PubMed:27733623). Isoform 2 might play a role in the assembly offocal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028,ECO:0000269|PubMed:27733623}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 954_1014 | 782 | 1015 | Domain | SH3 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 954_1014 | 119 | 271 | Domain | SH3 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 836_953 | 782 | 1015 | Region | Note=Linker |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 836_953 | 119 | 271 | Region | Note=Linker |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 795_830 | 782 | 1015 | Repeat | Note=Nebulin 23 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 137_172 | 119 | 271 | Repeat | Note=Nebulin 4 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 173_205 | 119 | 271 | Repeat | Note=Nebulin 5 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 206_241 | 119 | 271 | Repeat | Note=Nebulin 6 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 242_278 | 119 | 271 | Repeat | Note=Nebulin 7 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 279_313 | 119 | 271 | Repeat | Note=Nebulin 8 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 314_348 | 119 | 271 | Repeat | Note=Nebulin 9 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 349_385 | 119 | 271 | Repeat | Note=Nebulin 10 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 386_422 | 119 | 271 | Repeat | Note=Nebulin 11 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 423_459 | 119 | 271 | Repeat | Note=Nebulin 12 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 460_496 | 119 | 271 | Repeat | Note=Nebulin 13 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 497_533 | 119 | 271 | Repeat | Note=Nebulin 14 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 534_569 | 119 | 271 | Repeat | Note=Nebulin 15 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 570_599 | 119 | 271 | Repeat | Note=Nebulin 16 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 600_635 | 119 | 271 | Repeat | Note=Nebulin 17 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 636_666 | 119 | 271 | Repeat | Note=Nebulin 18 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 667_693 | 119 | 271 | Repeat | Note=Nebulin 19 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 694_728 | 119 | 271 | Repeat | Note=Nebulin 20 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 729_759 | 119 | 271 | Repeat | Note=Nebulin 21 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 760_794 | 119 | 271 | Repeat | Note=Nebulin 22 |
Tgene | >NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 795_830 | 119 | 271 | Repeat | Note=Nebulin 23 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 100_136 | 782 | 1015 | Repeat | Note=Nebulin 3 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 137_172 | 782 | 1015 | Repeat | Note=Nebulin 4 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 173_205 | 782 | 1015 | Repeat | Note=Nebulin 5 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 206_241 | 782 | 1015 | Repeat | Note=Nebulin 6 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 242_278 | 782 | 1015 | Repeat | Note=Nebulin 7 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 279_313 | 782 | 1015 | Repeat | Note=Nebulin 8 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 29_63 | 782 | 1015 | Repeat | Note=Nebulin 1 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 314_348 | 782 | 1015 | Repeat | Note=Nebulin 9 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 349_385 | 782 | 1015 | Repeat | Note=Nebulin 10 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 386_422 | 782 | 1015 | Repeat | Note=Nebulin 11 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 423_459 | 782 | 1015 | Repeat | Note=Nebulin 12 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 460_496 | 782 | 1015 | Repeat | Note=Nebulin 13 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 497_533 | 782 | 1015 | Repeat | Note=Nebulin 14 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 534_569 | 782 | 1015 | Repeat | Note=Nebulin 15 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 570_599 | 782 | 1015 | Repeat | Note=Nebulin 16 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 600_635 | 782 | 1015 | Repeat | Note=Nebulin 17 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 636_666 | 782 | 1015 | Repeat | Note=Nebulin 18 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 64_99 | 782 | 1015 | Repeat | Note=Nebulin 2 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 667_693 | 782 | 1015 | Repeat | Note=Nebulin 19 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 694_728 | 782 | 1015 | Repeat | Note=Nebulin 20 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 729_759 | 782 | 1015 | Repeat | Note=Nebulin 21 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000377122 | - | 22 | 28 | 760_794 | 782 | 1015 | Repeat | Note=Nebulin 22 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 100_136 | 119 | 271 | Repeat | Note=Nebulin 3 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 29_63 | 119 | 271 | Repeat | Note=Nebulin 1 |
Tgene | NEBL | chr17:34901666 | chr10:21101869 | ENST00000417816 | - | 3 | 7 | 64_99 | 119 | 271 | Repeat | Note=Nebulin 2 |
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FusionGeneSequence for GGNBP2_NEBL |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377122_chr10_21101869_-_264aa MARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDL KVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQS >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000417816_chr10_21101869_-_183aa MARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAP VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEF >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377159_chr10_21101869_-_183aa MARLVAVCRDGEEEFPFERRQIPLYIDDTLTVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVAP VLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377122_chr10_21101869_-_792nt ATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTG ACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAG AACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGACCTC AAAGTTTGGCGCACAGATCCTGGCTCCATCTTCGACCTTGATCCCCTGGAAGACAATATTCAGTCTAGAAGTCTCCATATGCTCTCTGAA AAGGCGAGTCACTATAGGCGACACTGGTCTCGATCCCATTCCAGCAGTACTTTCGGTACAGGTCTCGGAGACGACAGGTCAGAAATCTCC GAGATTTACCCTAGCTTTTCATGCTGCAGTGAGGTAACAAGACCGTCTGATGAAGGAGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGC CATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCC ATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGG >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000417816_chr10_21101869_-_549nt ATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTG ACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAG AACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCT GTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCAT TCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTC AACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTT >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377159_chr10_21101869_-_549nt ATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTTCCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTG ACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGGCTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAG AACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCCTCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCT GTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCAT TCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTC AACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377122_chr10_21101869_-_6882nt ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGACCTCAAAGTTTGGCGCACAGATCCTGGCTCCATCTTCGACCTTGATCC CCTGGAAGACAATATTCAGTCTAGAAGTCTCCATATGCTCTCTGAAAAGGCGAGTCACTATAGGCGACACTGGTCTCGATCCCATTCCAG CAGTACTTTCGGTACAGGTCTCGGAGACGACAGGTCAGAAATCTCCGAGATTTACCCTAGCTTTTCATGCTGCAGTGAGGTAACAAGACC GTCTGATGAAGGAGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGGCTACATGCACCAGACCAGTGTGTCATC CATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGCCCAGGATGAAGACGAGGTCTCCTTTAG AGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCAGAGAACAGGGAGAACAGGAATGCTCCC AGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATGTATCCCAAACCTAATCTTTTTAAAAGA TAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAATTAGACACACAGGTACCAGGAAGAAGGA ATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTCTGGACACCTGGTGCTGCTAATTGTGTT CATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAGAGAAGTTGATTGTCCCTTAAATGTAGT GTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGTAATGCAGCCAATAATTTCAAACCCGTT TTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAAACAGTGGCAGAAGGACAGTCTGGTTAA AATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGTTCCCTAGGCTGACTGGTATCTATTTAT TTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCTCAGTTCCACAGAATGTCAGGACCAAAT AACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCATTTACCCTGTTGCATGTCATGTAGATT CAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACTGATACCTAAAAGCCCTTTCTTCCTCTA GTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCACTCTAGTTTTGAAGGATTTACATCTTA GGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTAACTTAATGCCACCATTGATTTCAAAGT GAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCAGCAAACAAAGTTACCAATTCCATACAG AGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACCAAAACGGGTTAATCAAAAGACGTCCTT TTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATCAGAGATTTTTTAGTACAGGCCCAAGAG CCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCTTTATGCTAGCCCTTGCTGGTGGGTCTT GAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGTGTTTTTCTGATTGTGCCGTTTACTGTG ACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGCAAAACTGCAAAAAAGTACTAAGATGTA CGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAAACATCGTTTAAGGAAACGTTTACTAGT CCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGTGATTTCATTTTATTAGGCTAAAAGGGT AAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAATGCAGGCAAATAACTAGAGACTTCTTT TAAGGGGGTTTGGCTGGTTTTCTCTCACTGAAATGGCCAGTCGTGATTAAAGTGATAAAACCCCATATCTGTTTTGGTATATTGTACACA AACCTACAAAAATAAACTGAACTTGCAATATTTTTGCAAAAAAATCTGTCGTTAAAACTGAGGATAAAATACCTGCTCAATTTTATTTTA CTAAGTATATATTTACATTTCACCCAGGCAGGCCATTTTCTTTTGTGATTATAAGAAAGAGTAGTTGTTGATTAAATTTTCAGACTAAAT ATAGGACAGGTACAATTTTGGATAAATAGCACATTTATAAGAACCGCAATGAAAACTGACTTGAAATAATGCTTGTAATCAGGAAAGTAA TTTCATCCACCGATTTCAAAACCAGATTCACTGAGCATAAAAGTCAATACATATTTGAGGAATAAGTCTCCTAAAATTTTAAGCTTCACG TAATAATGTTTGCATAGCAAAATATTTCTGCTTCAAGCCTTTAGGAATTAAGATCTGATCAGAATTTAACTAAAGGGTAGTTGTTTTACA ATGAAGACTAAAACTGAACAAGATGTTGCATGCTCTTGAGGCCATAATTTGGTAGTGTTGGCAGTTGTTAATAAAGCTTGTCAGGATGTT AAGCATCTCAGGAGAAATATTGGAAAATTATATGTATAAAACCAAAGTGCTATTTTTAAAAGCATCATTTAAAAAAAAATGACATGCCTG AACAACTTTTCCACTTTCCACGTGCTTCCCTCCCACCTTTGGTTTGGCAACAGGTATCTCGTGCATGAAGCTGACAGCTAAAGAAGATTT TAAAAATTGAGTTAAAGATGACTGTGTAAATGTCCAAGCACAGAGAGCATGCACCTGACTTTCTAAAGTTTGATGTGTTCTCAAGCCTGA CAGAAGCACAAGGAACAGTTTGATACACTTTTAAAAGGTTCTGAAAACAAAGCTGTATAGGGATCCTCTCTCTCTTGAGCAAAGTATAGC AACAGAATATATTGCTTTTGTTGTAAGCTTTTGTAGTACATGTTTTTACTAATAATTCTTGTTCTCTAGAAAGCTTTCTATTTCTAACCT ATGGCAAAATGAATCCTTCATGTCTTCTTGTTATTGTTTACACACTTGCAGTGTAGCCCAGTTTGAAATATTTATTTGGTTATCAACTGC CCATGGAGGAGGCTCTTGATGATCCCAGGTCTCCTCGACCTCCATACACCACACAGGCATTTGTAAGCACAGTTTCCACAAGCACCTTGT AGGAATATGGATAAGATTAGACCAGCCCCTCTCTGTCCACTGGGTTTATTTCTTGAAGAAGATGCAGATCTGGTTTTTCCAATGTGCCAC AGTCTTTCCTTATCCTCTCCATGCTGAGCTTGACAACACTCTGGGAATGAGGAACAAGACTTTTTCTAAAAAGATAGTGGAAGTTCAAGG GATGTACCTCGTTTTCAGGTTCATCCATCTCCAGTGGAATGTTTTCAATAAAAGATGAAGAAAATGTGTGTGATCTTTAATAACACATCC CTATAGAAAGTGGATAAAAGATATACCAAAACTGTAATACAGATATATACAAATATAGGTGCCTTTTTGATTACTCTTGTTTGTCTAGTA TGCTCTTGGAAAGAAAACCAAGCAAGCAAGTTGCTGCCTATTCTATAGTAATATTTTATTACACATGATTGATATTTTTGTGGTAGGGAA GTGGGATGCTCCTCAGATATTAAAGGTGTTAGCTGATTGTATTTTATCTCTAAAGATTTAGAACTTTAGAAAATGCCGACTTCTTCCATC TATTTCTGAAAGGTTCTTTGTGGATTTATATAGAGTTGAGCTATATAAACATTAACTTTAGATTTGGGATTTAAAATGCCTATTGTAAGA TAGAATAATTGTGAGGCTGGATTCACTACACAAGATGAACTTCACTTCATAAATTAATTATACCTTAGCGATTTGCTTCTGATAATCTAA AAGTGGCTAGATTGTGGTTGTTTTGGTTAAGGTGATATGGAGGTGGGAGAGCTTTTAGTTAAGTAAGAAGCTATGTAAACTGACAAGGAT GCTAAAATAAAAGTCTCTGAAGTATTCCATGCCTTTTGGACCCTTTCCTCGCAACTAACTGTCAACTGTTGATCAAAAAAGTCAAGGCAT TGTATGTTGCTTCTGTGGTTATTATTCTGTGATGCTTAGACTACTTGAACCCATAAACTTGGAAGAATCTTTGAGCAAATTTTCTCAGTT GTCTGTATGACTTCAGTATATTCCTGGGAATGCCATAGGATTTTTTGTGCTTGATACATGGTATCCAGTTTGCATAGTATCACTTCTTTG TAATCCAGTTGCTGTTAAGAATGATGTACTTTAAAGGAAAAGAGAAAACTGCATCACAGTCCCATTCTCCAGTGTCCATGCAATGAATTG CTGAGCATTTAGGAAGCAGCACCAAGTCTATTACAGGCATGGTGTGAAACTTGATGTTTGACCTGTGATCAAAATTGAACCATTGTACAG TTTGGCTTCTGTTTGCTTCAAAATATGTAGAATTGTGGTTGATGATTAATTTGCGAGACTAACTTTGAGAGTGTAACAGTTTTGAAGAAA ACATTGAATGTTTTGCAAATGAAGGGGCTTCACGGAATGTTACAATGTTACTAATATAATTTGGCTTTTGTTATGCAAATTGTTAACACC AGCTATTAAAATATATTTTAGTAGAAATGCTTTAATTCATATTTTTTTCCTCTACACTGTGAATCTTTAAGCCTTGGTGGACTAGAGCAA CATCGTGCTGCCCAAAGGACTAACCTATGCAAACTAGTTCACATTTTAGTGGATGTCGCAGTTAATGTGTAATAAGACATTATTTCCCCT GCATAATGTACAACAGCATTGAAATGACACATTAAGCCTAGCATCACATTGTATAGTACAGTCACTCACAAACCCTTCAAGGCTACCCTA ATCATTAACATTAATATTTGTTTAAAAGCAAATCACCGATTTATCTATTGAAACTACTTAAATGACGGCAAACCAGGAATGACAGATGGC TGTGTCAGCAATGGCTTTAATGTGTTCCCTGCAAGTGGTCTCCTATGATAGAACTGCGTTCTCAAATGCACTCTCTTCAGGGTCTTAATA TTCTGTGTTTTCTCTCTGTATTTGTAAAACATTATAACACATTAATTTCCTATCTCTACACATTTGGTTTGCTTAAATAAATGCAGGATA TAAAAAAAATGGTTCACTTCTTGGCTCTCACCGTGGTTTCTTGGAGCATGGGTTGTTAGATGCAAGCAATGCACCCTAATAATACCCCGG GTCTGAGATTTAACATGACAACTCACATCAAATCGCATCAGAGGTGTGTGCTGCCTTCAGTGCATTTACATTGGTGAATCAGTCAAGATA TTTTCCTCCCCCAAATAAACTTAGTTGTAAGTGATAACAATATTATGCTTCTCCAAGCTCAGTATCTTTCTGATTTTATATCAAAGTACC GCAACAATGCATCATTGTAGTTAATTTATTTCAAGAATAAATTCCTCATATGTCCTCAATAGTACAATTCTAATTTTCTTCTATTCATAA GATGAAAGAAATGGTTTGGAGCATAGAATAGAAAGTGCACAAATTGAGTACATAAAATGGGAAGCAACTGATTTCTCAGCTAAGAAAGGC TCATTTATCACAGAACACAATTGCTTTTCTCCCCCCACTACGCTTCCCATAATTGAAAAAGTGAGTCCCTATTTTTCACACTCATATAAA TCTATGCGATTTGGATGCTAGTCTTATTGTATTATTTTGTAAAACTTTCTCTTTGGCTCATAATCCTTCCTAATTGTAAATTGATAAACT >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000417816_chr10_21101869_-_2706nt ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGG CTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGC CCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCA GAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATG TATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAAT TAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTC TGGACACCTGGTGCTGCTAATTGTGTTCATGGTTTCCTTTGATTGGCTATTGAACCCTTCTGGGAAATGTATTTTTGTAGACTTTAATAG AGAAGTTGATTGTCCCTTAAATGTAGTGTGTGTTTGAAACTTCTTAGCTGTCACTTTGGAATCACCCCAAGCCAATTCTCTTAACTCTGT AATGCAGCCAATAATTTCAAACCCGTTTTGCTTTTGAGTCATGAGGCAATTTCCAATATTAGTGAAAATTGCCCAATATAATAAGTGTAA ACAGTGGCAGAAGGACAGTCTGGTTAAAATTATATTGACTGGTGGCCTTAGGGATCTAGAAACTTCTACTAAACAGAGAAATTTCCTTGT TCCCTAGGCTGACTGGTATCTATTTATTTCTCATTTGTACCAAGGCATCTCCTACTCTCCATTTATATTCTATGGACCCAAGTCTATGCT CAGTTCCACAGAATGTCAGGACCAAATAACTTCACAGCTACTCTGCAAAGGGCAAATTATAATGTCATTGATATAATTTCCCTAGTAGCA TTTACCCTGTTGCATGTCATGTAGATTCAAGCTTCTGTAACATAGGCAGCTGCACTGCGCGTTCCTATTATTGAAGCAAAAAGGGTGACT GATACCTAAAAGCCCTTTCTTCCTCTAGTCGCCAGCTCATCAGAAAAACATACTTTGAAAAGATGCTTGAGATTTTCCTGCTGCATCGCA CTCTAGTTTTGAAGGATTTACATCTTAGGAAATAACATGTATACTCTAGTAAATAAGCGATTTAGGTGTTCCATTGAACAGCTTTGATTA ACTTAATGCCACCATTGATTTCAAAGTGAAGAAAATGTAACAGAAGCCAGTGAAGCAATGGAAGCTGGAGTGTGACTGGAAAAATACTCA GCAAACAAAGTTACCAATTCCATACAGAGATGATCTGGTATCTTCTTTTGGAAAATGGTATTCAAATTCTGGAATGGAAATCTAGCCACC AAAACGGGTTAATCAAAAGACGTCCTTTTCCATTTTTTTTTGCTTTTATTTTCTAAATCATTTTTAAGGGAATGAAACAGGAATGTCATC AGAGATTTTTTAGTACAGGCCCAAGAGCCTGTTCTCTAAGAAAGAAATTGTTGCCATGTTTTGATTTTCGAATAAGTGACTTTGCAGGCT TTATGCTAGCCCTTGCTGGTGGGTCTTGAAATTTCATCCAGAGTCTGCAGTCCAGGTCACCAAGCCAGCGGCACCCGTCGGCAACCCTGT GTTTTTCTGATTGTGCCGTTTACTGTGACCTGCAACGGGGTGGCATTCACTTAGGGTCTGACTTCACAGCTATGACAAAACCGAAAAAGC AAAACTGCAAAAAAGTACTAAGATGTACGGGTCTTGGGGATATCTGCCTTATATGTTATATTCAAGGAAATTAACAAAACATCCTGTAAA ACATCGTTTAAGGAAACGTTTACTAGTCCAAAGGCCAAAGCTAATTTATTTCCACTTTAGAAAAGTTAGCACATGCTTTTGAAAATCTGT GATTTCATTTTATTAGGCTAAAAGGGTAAATAGGCTTTATTACACTGAAGCTGCATCTATATGTCACTGACATAAAGTTGAAAAAATAAA >In-frame_GGNBP2_ENST00000304718_chr17_34901666_+_NEBL_ENST00000377159_chr10_21101869_-_1141nt ACCTTCCCCTCGTCCCCCGCCCTCCTTCTTCCACTCCCCGCGGCGCGAGCGGCTGACTGCCCGTAGAGGAAACGACATTCGGAGCTGCGC TCCCGCCCAGGCCGGCCCTGACGCGGGCCTCGTCAGCCAGTAACAGGGAGCAGAGGTGGGAGTTAGCGAGGCGACCACGAAAACGGTGAA GGTCGGAACCGACAGCCTCCTCCGAGAAGGGCAGGAGCTGGGAGGAGGCGGCAGCGGCGGCGGCAGAAACAGCAGCGGCGGCGGCGGCGG CAGCTGGGAGGAGGTGGTGACGGTGGCAACGGCAGCGTCGGGGACGATGGCGCGACTCGTGGCAGTGTGCAGGGACGGGGAGGAGGAGTT CCCCTTCGAGAGGAGGCAGATTCCCCTCTACATAGACGACACCCTGACGGTAAAATACCATGAAGATTTTGAAAAAACAAAGGGGAGAGG CTTTACTCCCGTCGTGGACGATCCTGTGACAGAGAGAGTGAGGAAGAACACCCAGGTGGTCAGCGATGCTGCCTATAAAGGGGTCCACCC TCACATCGTGGAGATGGACAGGAGACCTGGAATCATTGTTGCACCTGTTCTTCCCGGAGCCTATCAGCAAAGCCATTCCCAAGGCTATGG CTACATGCACCAGACCAGTGTGTCATCCATGAGATCAATGCAGCATTCACCAAATCTAAGGACCTACCGAGCCATGTACGATTACAGTGC CCAGGATGAAGACGAGGTCTCCTTTAGAGACGGCGACTACATCGTCAACGTGCAGCCTATTGACGATGGCTGGATGTACGGCACAGTGCA GAGAACAGGGAGAACAGGAATGCTCCCAGCGAATTACATTGAGTTTGTTAATTAATTATTTCTCCCTGCCCTTTGAGCTTTATTCTAATG TATCCCAAACCTAATCTTTTTAAAAGATAGAAGATACTTTTAAGACAACTTGGCCATTATTTTACAATGATGTATCCTTCCTTTGACAAT TAGACACACAGGTACCAGGAAGAAGGAATGACCTCTGGGCTGAAAACAGCAGCATTTTCAGTAATTCCTACAAACAAAAATCTTTGTGTC |
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FusionGenePPI for GGNBP2_NEBL |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GGNBP2 | FBXW11, PAK4, BTRC, CNOT11, ZNF331 | NEBL | MYPN, ZYX, MED28, XIRP2, XIRP1, PRKAB2, TRIM63, TRIM55, ACTN3, GOLGA2, TRIM27, TRAF1, TRAF2, MAD1L1, HOMER3, GMCL1, CCDC136, LZTS2, MIPOL1, FAM9B, NUTM1, ZDHHC17, CEP170, CEP128, SCLT1, DCTN1, CDH1, ZNF764, GCHFR, DHX38, CARKD |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GGNBP2_NEBL |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GGNBP2_NEBL |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |