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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14585

FusionGeneSummary for GGA2_NUCKS1

check button Fusion gene summary
Fusion gene informationFusion gene name: GGA2_NUCKS1
Fusion gene ID: 14585
HgeneTgene
Gene symbol

GGA2

NUCKS1

Gene ID

23062

64710

Gene namegolgi associated, gamma adaptin ear containing, ARF binding protein 2nuclear casein kinase and cyclin dependent kinase substrate 1
SynonymsVEARJC7|NUCKS
Cytomap

16p12.2

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-binding protein GGA2VHS domain and ear domain of gamma-adaptinVHS domain and ear domain-containing proteingamma-adaptin-related protein 2golgi-localized, gamma ear-containing, ARF-binding protein 2nuclear ubiquitous casein and cyclin-dependent kinase substrate 1P1nuclear ubiquitous casein kinase and cyclin-dependent kinase substratepotential LAG1 interactor
Modification date2018052220180519
UniProtAcc

Q9UJY4

Q9H1E3

Ensembl transtripts involved in fusion geneENST00000309859, ENST00000567468, 
ENST00000569182, 
ENST00000367142, 
ENST00000464938, 
Fusion gene scores* DoF score4 X 4 X 3=4811 X 15 X 5=825
# samples 718
** MAII scorelog2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(18/825*10)=-2.1963972128035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GGA2 [Title/Abstract] AND NUCKS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUCKS1

GO:0031297

replication fork processing

26323318


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ338666GGA2chr16

23477493

-NUCKS1chr1

205683186

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000309859ENST00000367142GGA2chr16

23477493

-NUCKS1chr1

205683186

+
intron-intronENST00000309859ENST00000464938GGA2chr16

23477493

-NUCKS1chr1

205683186

+
intron-3UTRENST00000567468ENST00000367142GGA2chr16

23477493

-NUCKS1chr1

205683186

+
intron-intronENST00000567468ENST00000464938GGA2chr16

23477493

-NUCKS1chr1

205683186

+
intron-3UTRENST00000569182ENST00000367142GGA2chr16

23477493

-NUCKS1chr1

205683186

+
intron-intronENST00000569182ENST00000464938GGA2chr16

23477493

-NUCKS1chr1

205683186

+

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FusionProtFeatures for GGA2_NUCKS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GGA2

Q9UJY4

NUCKS1

Q9H1E3

Plays a role in protein sorting and trafficking betweenthe trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and bindsubiquitinated proteins and membrane cargo molecules with acytosolic acidic cluster-dileucine (AC-LL) motif.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GGA2_NUCKS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GGA2_NUCKS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GGA2_NUCKS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GGA2_NUCKS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource