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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14577

FusionGeneSummary for GFPT2_GFPT2

check button Fusion gene summary
Fusion gene informationFusion gene name: GFPT2_GFPT2
Fusion gene ID: 14577
HgeneTgene
Gene symbol

GFPT2

GFPT2

Gene ID

9945

9945

Gene nameglutamine-fructose-6-phosphate transaminase 2glutamine-fructose-6-phosphate transaminase 2
SynonymsGFAT|GFAT 2|GFAT2GFAT|GFAT 2|GFAT2
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionglutamine--fructose-6-phosphate aminotransferase [isomerizing] 2D-fructose-6-phosphate amidotransferase 2glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2glutamine: fructose-6-phosphate aminotransferase 2glutamine:fructose-6-phosphateglutamine--fructose-6-phosphate aminotransferase [isomerizing] 2D-fructose-6-phosphate amidotransferase 2glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2glutamine: fructose-6-phosphate aminotransferase 2glutamine:fructose-6-phosphate
Modification date2018052320180523
UniProtAcc

O94808

O94808

Ensembl transtripts involved in fusion geneENST00000253778, ENST00000520165, 
ENST00000253778, ENST00000520165, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 3 X 2=12
# samples 65
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GFPT2 [Title/Abstract] AND GFPT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW867731GFPT2chr5

179728102

+GFPT2chr5

179727892

-
ChiTaRS3.1BE841311GFPT2chr5

179728102

+GFPT2chr5

179727892

-
ChiTaRS3.1BE841297GFPT2chr5

179727892

+GFPT2chr5

179728102

-
ChiTaRS3.1AW867686GFPT2chr5

179727892

+GFPT2chr5

179728102

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000253778ENST00000253778GFPT2chr5

179728102

+GFPT2chr5

179727892

-
intron-intronENST00000253778ENST00000520165GFPT2chr5

179728102

+GFPT2chr5

179727892

-
intron-3UTRENST00000520165ENST00000253778GFPT2chr5

179728102

+GFPT2chr5

179727892

-
intron-intronENST00000520165ENST00000520165GFPT2chr5

179728102

+GFPT2chr5

179727892

-
intron-3UTRENST00000253778ENST00000253778GFPT2chr5

179727892

+GFPT2chr5

179728102

-
intron-intronENST00000253778ENST00000520165GFPT2chr5

179727892

+GFPT2chr5

179728102

-
intron-3UTRENST00000520165ENST00000253778GFPT2chr5

179727892

+GFPT2chr5

179728102

-
intron-intronENST00000520165ENST00000520165GFPT2chr5

179727892

+GFPT2chr5

179728102

-

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FusionProtFeatures for GFPT2_GFPT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GFPT2

O94808

GFPT2

O94808

Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins. Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GFPT2_GFPT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GFPT2_GFPT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GFPT2_GFPT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GFPT2_GFPT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource