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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14576

FusionGeneSummary for GFPT2_BRD8

check button Fusion gene summary
Fusion gene informationFusion gene name: GFPT2_BRD8
Fusion gene ID: 14576
HgeneTgene
Gene symbol

GFPT2

BRD8

Gene ID

9945

10902

Gene nameglutamine-fructose-6-phosphate transaminase 2bromodomain containing 8
SynonymsGFAT|GFAT 2|GFAT2SMAP|SMAP2|p120
Cytomap

5q35.3

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionglutamine--fructose-6-phosphate aminotransferase [isomerizing] 2D-fructose-6-phosphate amidotransferase 2glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2glutamine: fructose-6-phosphate aminotransferase 2glutamine:fructose-6-phosphatebromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120
Modification date2018052320180519
UniProtAcc

O94808

Q9H0E9

Ensembl transtripts involved in fusion geneENST00000253778, ENST00000520165, 
ENST00000254900, ENST00000230901, 
ENST00000402931, ENST00000411594, 
ENST00000455658, ENST00000515014, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 3 X 3=27
# samples 63
** MAII scorelog2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GFPT2 [Title/Abstract] AND BRD8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD8

GO:0043967

histone H4 acetylation

14966270

TgeneBRD8

GO:0043968

histone H2A acetylation

14966270


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-BF-A5EQ-01AGFPT2chr5

179780211

-BRD8chr5

137492956

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253778ENST00000254900GFPT2chr5

179780211

-BRD8chr5

137492956

-
5CDS-intronENST00000253778ENST00000230901GFPT2chr5

179780211

-BRD8chr5

137492956

-
5CDS-intronENST00000253778ENST00000402931GFPT2chr5

179780211

-BRD8chr5

137492956

-
5CDS-intronENST00000253778ENST00000411594GFPT2chr5

179780211

-BRD8chr5

137492956

-
5CDS-intronENST00000253778ENST00000455658GFPT2chr5

179780211

-BRD8chr5

137492956

-
5CDS-intronENST00000253778ENST00000515014GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000254900GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000230901GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000402931GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000411594GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000455658GFPT2chr5

179780211

-BRD8chr5

137492956

-
intron-intronENST00000520165ENST00000515014GFPT2chr5

179780211

-BRD8chr5

137492956

-

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FusionProtFeatures for GFPT2_BRD8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GFPT2

O94808

BRD8

Q9H0E9

Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins. May act as a coactivator during transcriptionalactivation by hormone-activated nuclear receptors (NR). Isoform 2stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1,RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 arecomponents of the NuA4 histone acetyltransferase (HAT) complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. NuA4 may also play a direct role in DNArepair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:10517671,ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GFPT2_BRD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GFPT2_BRD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GFPT2POT1, CUL3, UBC, DCP2, SUSD4, SIRT6, MYBPHL, SIAE, DPEP2, ARSA, GPHA2, CCT8, ACADM, AHSA1, ATP5B, FASN, PPP2R1A, SARS, XPO1, TARSL2, TP53, FBXW7, GFPT1, ACOT9, FIGNL1, SALL2, FDX1L, LRP1, SLAMF1, DKK3, MTNR1ABRD8RXRA, THRB, ING3, MRGBP, TP53, TP63, TP73, MORF4L1, MORF4L2, MYC, MAX, DMAP1, KAT5, SOX2, MIS18A, FSD2, PLAC1, FOXR1, FOXR2, HIST1H2BA, YEATS4, HIST1H2BG, EWSR1, TRRAP, CDC5L, EPC1, MBTD1, RUVBL1, RUVBL2, MYCL, MEAF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GFPT2_BRD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GFPT2_BRD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRD8C0014175Endometriosis1CTD_human