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Fusion gene ID: 14576 |
FusionGeneSummary for GFPT2_BRD8 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GFPT2_BRD8 | Fusion gene ID: 14576 | Hgene | Tgene | Gene symbol | GFPT2 | BRD8 | Gene ID | 9945 | 10902 |
Gene name | glutamine-fructose-6-phosphate transaminase 2 | bromodomain containing 8 | |
Synonyms | GFAT|GFAT 2|GFAT2 | SMAP|SMAP2|p120 | |
Cytomap | 5q35.3 | 5q31.2 | |
Type of gene | protein-coding | protein-coding | |
Description | glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2D-fructose-6-phosphate amidotransferase 2glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2glutamine: fructose-6-phosphate aminotransferase 2glutamine:fructose-6-phosphate | bromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O94808 | Q9H0E9 | |
Ensembl transtripts involved in fusion gene | ENST00000253778, ENST00000520165, | ENST00000254900, ENST00000230901, ENST00000402931, ENST00000411594, ENST00000455658, ENST00000515014, | |
Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 3 X 3 X 3=27 |
# samples | 6 | 3 | |
** MAII score | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GFPT2 [Title/Abstract] AND BRD8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BRD8 | GO:0043967 | histone H4 acetylation | 14966270 |
Tgene | BRD8 | GO:0043968 | histone H2A acetylation | 14966270 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-BF-A5EQ-01A | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000253778 | ENST00000254900 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
5CDS-intron | ENST00000253778 | ENST00000230901 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
5CDS-intron | ENST00000253778 | ENST00000402931 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
5CDS-intron | ENST00000253778 | ENST00000411594 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
5CDS-intron | ENST00000253778 | ENST00000455658 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
5CDS-intron | ENST00000253778 | ENST00000515014 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000254900 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000230901 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000402931 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000411594 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000455658 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
intron-intron | ENST00000520165 | ENST00000515014 | GFPT2 | chr5 | 179780211 | - | BRD8 | chr5 | 137492956 | - |
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FusionProtFeatures for GFPT2_BRD8 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GFPT2 | BRD8 |
Controls the flux of glucose into the hexosaminepathway. Most likely involved in regulating the availability ofprecursors for N- and O-linked glycosylation of proteins. | May act as a coactivator during transcriptionalactivation by hormone-activated nuclear receptors (NR). Isoform 2stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1,RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 arecomponents of the NuA4 histone acetyltransferase (HAT) complexwhich is involved in transcriptional activation of select genesprincipally by acetylation of nucleosomal histones H4 and H2A.This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteinswhich positively regulate transcription. This complex may berequired for the activation of transcriptional programs associatedwith oncogene and proto-oncogene mediated growth induction, tumorsuppressor mediated growth arrest and replicative senescence,apoptosis, and DNA repair. NuA4 may also play a direct role in DNArepair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:10517671,ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GFPT2_BRD8 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GFPT2_BRD8 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GFPT2 | POT1, CUL3, UBC, DCP2, SUSD4, SIRT6, MYBPHL, SIAE, DPEP2, ARSA, GPHA2, CCT8, ACADM, AHSA1, ATP5B, FASN, PPP2R1A, SARS, XPO1, TARSL2, TP53, FBXW7, GFPT1, ACOT9, FIGNL1, SALL2, FDX1L, LRP1, SLAMF1, DKK3, MTNR1A | BRD8 | RXRA, THRB, ING3, MRGBP, TP53, TP63, TP73, MORF4L1, MORF4L2, MYC, MAX, DMAP1, KAT5, SOX2, MIS18A, FSD2, PLAC1, FOXR1, FOXR2, HIST1H2BA, YEATS4, HIST1H2BG, EWSR1, TRRAP, CDC5L, EPC1, MBTD1, RUVBL1, RUVBL2, MYCL, MEAF6 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GFPT2_BRD8 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GFPT2_BRD8 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BRD8 | C0014175 | Endometriosis | 1 | CTD_human |