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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14549

FusionGeneSummary for GDPD5_ACER3

check button Fusion gene summary
Fusion gene informationFusion gene name: GDPD5_ACER3
Fusion gene ID: 14549
HgeneTgene
Gene symbol

GDPD5

ACER3

Gene ID

81544

55331

Gene nameglycerophosphodiester phosphodiesterase domain containing 5alkaline ceramidase 3
SynonymsGDE2|PP1665APHC|PHCA|PLDECO
Cytomap

11q13.4-q13.5

11q13.5

Type of geneprotein-codingprotein-coding
Descriptionglycerophosphodiester phosphodiesterase domain-containing protein 5glycerophosphodiester phosphodiesterase 2alkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline
Modification date2018051920180519
UniProtAcc

Q8WTR4

Q9NUN7

Ensembl transtripts involved in fusion geneENST00000336898, ENST00000376282, 
ENST00000529095, ENST00000526177, 
ENST00000533784, ENST00000529721, 
ENST00000533805, ENST00000443276, 
ENST00000532485, ENST00000530182, 
ENST00000526597, ENST00000533873, 
ENST00000538157, ENST00000544113, 
Fusion gene scores* DoF score3 X 3 X 2=187 X 5 X 4=140
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GDPD5 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

TgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A2JB-06AGDPD5chr11

75167802

-ACER3chr11

76722374

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336898ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000336898ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000336898ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000336898ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000336898ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000336898ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000376282ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000529095ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000526177ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533784ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000529721ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
intron-intronENST00000533805ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000532485GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000530182GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000526597GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000533873GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000538157GDPD5chr11

75167802

-ACER3chr11

76722374

+
5CDS-intronENST00000443276ENST00000544113GDPD5chr11

75167802

-ACER3chr11

76722374

+

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FusionProtFeatures for GDPD5_ACER3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GDPD5

Q8WTR4

ACER3

Q9NUN7

Promotes neurite formation. Cooperates with PRDX1 todrive postmitotic motor neuron differentiation. Theglycerophosphodiester phosphodiesterase activity may be requiredfor its role in neuronal differentiation. May contribute to theosmotic regulation of cellular glycerophosphocholine. Hydrolyzes only phytoceramide into phytosphingosine andfree fatty acid. Does not have reverse activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GDPD5_ACER3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GDPD5_ACER3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GDPD5PLSCR1, PEX5, SIAH1, TRIP6, KRTAP26-1, LYPD3, ROBO1, GPD2, PIGQ, SELT, TMEM55A, IGSF8, LEMD2, SCAMP4, ZMPSTE24, VTI1B, NDUFS4, KCNJ11, ZDHHC9, TYW1, C1orf43, STX7, NDUFA12, STX8, CHSY3, EDA, RETSAT, ADCY6, NDUFS6, ZDHHC18, GPR89B, TEX264, TMEM205, GPRC5C, MARC1, GOLIM4, THEM6, SGPP1, FAM213A, NDC1ACER3ELAVL1, MLH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GDPD5_ACER3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GDPD5_ACER3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACER3C0025202melanoma1CTD_human