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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14542

FusionGeneSummary for GDI2_GRAMD1C

check button Fusion gene summary
Fusion gene informationFusion gene name: GDI2_GRAMD1C
Fusion gene ID: 14542
HgeneTgene
Gene symbol

GDI2

GRAMD1C

Gene ID

2665

54762

Gene nameGDP dissociation inhibitor 2GRAM domain containing 1C
SynonymsHEL-S-46e|RABGDIB-
Cytomap

10p15.1

3q13.31

Type of geneprotein-codingprotein-coding
Descriptionrab GDP dissociation inhibitor betaGDI-2epididymis secretory sperm binding protein Li 46eguanosine diphosphate dissociation inhibitor 2rab GDI betarab GDP-dissociation inhibitor, betaGRAM domain-containing protein 1C
Modification date2018051920180519
UniProtAcc

P50395

Q8IYS0

Ensembl transtripts involved in fusion geneENST00000380191, ENST00000479928, 
ENST00000380132, ENST00000380181, 
ENST00000479212, ENST00000358160, 
ENST00000452134, ENST00000472026, 
ENST00000440446, 
Fusion gene scores* DoF score6 X 6 X 4=1442 X 2 X 1=4
# samples 62
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: GDI2 [Title/Abstract] AND GRAMD1C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW390850GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000380191ENST00000479212GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000380191ENST00000358160GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-5UTRENST00000380191ENST00000452134GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380191ENST00000472026GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380191ENST00000440446GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000479928ENST00000479212GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000479928ENST00000358160GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-5UTRENST00000479928ENST00000452134GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000479928ENST00000472026GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000479928ENST00000440446GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000380132ENST00000479212GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000380132ENST00000358160GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-5UTRENST00000380132ENST00000452134GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380132ENST00000472026GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380132ENST00000440446GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000380181ENST00000479212GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-3UTRENST00000380181ENST00000358160GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-5UTRENST00000380181ENST00000452134GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380181ENST00000472026GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+
intron-intronENST00000380181ENST00000440446GDI2chr10

5808046

-GRAMD1Cchr3

113601608

+

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FusionProtFeatures for GDI2_GRAMD1C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GDI2

P50395

GRAMD1C

Q8IYS0

Regulates the GDP/GTP exchange reaction of most Rabproteins by inhibiting the dissociation of GDP from them, and thesubsequent binding of GTP to them.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GDI2_GRAMD1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GDI2_GRAMD1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GDI2_GRAMD1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GDI2_GRAMD1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGDI2C0279626Squamous cell carcinoma of esophagus1CTD_human