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Fusion gene ID: 14531 |
FusionGeneSummary for GDE1_TIAL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GDE1_TIAL1 | Fusion gene ID: 14531 | Hgene | Tgene | Gene symbol | GDE1 | TIAL1 | Gene ID | 51573 | 7073 |
| Gene name | glycerophosphodiester phosphodiesterase 1 | TIA1 cytotoxic granule associated RNA binding protein like 1 | |
| Synonyms | 363E6.2|MIR16 | TCBP|TIAR | |
| Cytomap | 16p12.3 | 10q26.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16 | nucleolysin TIART-cluster binding proteinTIA-1-related nucleolysinaging-associated gene 7 protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9NZC3 | Q01085 | |
| Ensembl transtripts involved in fusion gene | ENST00000353258, | ENST00000369093, ENST00000463089, ENST00000369092, ENST00000436547, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: GDE1 [Title/Abstract] AND TIAL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-ZG-A9N3-01A | GDE1 | chr16 | 19528336 | - | TIAL1 | chr10 | 121347760 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000353258 | ENST00000369093 | GDE1 | chr16 | 19528336 | - | TIAL1 | chr10 | 121347760 | - |
| 5CDS-intron | ENST00000353258 | ENST00000463089 | GDE1 | chr16 | 19528336 | - | TIAL1 | chr10 | 121347760 | - |
| 5CDS-5UTR | ENST00000353258 | ENST00000369092 | GDE1 | chr16 | 19528336 | - | TIAL1 | chr10 | 121347760 | - |
| 5CDS-5UTR | ENST00000353258 | ENST00000436547 | GDE1 | chr16 | 19528336 | - | TIAL1 | chr10 | 121347760 | - |
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FusionProtFeatures for GDE1_TIAL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GDE1 | TIAL1 |
| Has glycerophosphoinositol phosphodiesterase activity.Hydrolyzes lysoglycerophospholipids to produce lysophosphatidicacid (LPA) and the corresponding amines. Has little or no activitytowards glycerophosphocholine. GDE1 activity can be modulated byG-protein signaling pathways (By similarity).{ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}. | RNA-binding protein. Possesses nucleolytic activityagainst cytotoxic lymphocyte target cells. May be involved inapoptosis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 1_3 | 145 | 332 | Topological domain | Cytoplasmic |
| Hgene | GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 4_24 | 145 | 332 | Transmembrane | Helical |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000369093 | - | 0 | 12 | 205_277 | 10 | 393 | Domain | RRM 3 |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000369093 | - | 0 | 12 | 97_175 | 10 | 393 | Domain | RRM 2 |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000369093 | - | 0 | 12 | 9_85 | 10 | 393 | Domain | RRM 1 |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000436547 | - | 0 | 12 | 205_277 | 10 | 376 | Domain | RRM 3 |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000436547 | - | 0 | 12 | 97_175 | 10 | 376 | Domain | RRM 2 |
| Tgene | >TIAL1 | chr16:19528336 | chr10:121347760 | ENST00000436547 | - | 0 | 12 | 9_85 | 10 | 376 | Domain | RRM 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 65_331 | 145 | 332 | Domain | Note=GP-PDE |
| Hgene | >GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 25_247 | 145 | 332 | Topological domain | Lumenal |
| Hgene | >GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 269_331 | 145 | 332 | Topological domain | Cytoplasmic |
| Hgene | >GDE1 | chr16:19528336 | chr10:121347760 | ENST00000353258 | - | 2 | 6 | 248_268 | 145 | 332 | Transmembrane | Helical |
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FusionGeneSequence for GDE1_TIAL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GDE1_ENST00000353258_chr16_19528336_-_TIAL1_ENST00000369093_chr10_121347760_-_528aa MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAK NGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQP DSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFA PFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVY CGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GDE1_ENST00000353258_chr16_19528336_-_TIAL1_ENST00000369093_chr10_121347760_-_1584nt ATGTGGCTGTGGGAGGACCAGGGCGGCCTCCTGGGCCCTTTCTCCTTCCTGCTGCTAGTGCTGCTGCTGGTGACGCGGAGCCCGGTCAAT GCCTGCCTCCTCACCGGCAGCCTCTTCGTTCTACTGCGCGTCTTCAGCTTTGAGCCGGTGCCCTCTTGCAGGGCCCTGCAGGTGCTCAAG CCCCGGGACCGCATTTCTGCCATCGCCCACCGTGGCGGCAGCCACGACGCGCCCGAGAACACGCTGGCGGCCATTCGGCAGGCAGCTAAG AATGGAGCAACAGGCGTGGAGTTGGACATTGAGTTTACTTCTGACGGGATTCCTGTCTTAATGCACGATAACACAGTAGATAGGACGACT GATGGGACTGGGCGATTGTGTGATTTGACATTTGAACAAATTAGGAAGCTGAATCCTGCAGCAAACCACAGACTCAGATACGTAGGTAAC CTTTCCAGAGATGTGACAGAAGTCCTTATACTTCAGTTGTTCAGTCAGATTGGACCCTGTAAAAGCTGTAAAATGATAACAGAGCAACCC GATAGCAGAAGGGTCAACTCTTCTGTTGGATTTTCTGTTTTGCAGCATACAAGCAATGACCCATATTGCTTTGTGGAATTTTATGAACAC AGAGATGCAGCTGCTGCATTAGCTGCTATGAATGGGAGAAAAATTTTGGGAAAGGAGGTCAAAGTAAACTGGGCAACCACACCAAGTAGC CAGAAAAAAGATACTTCCAATCACTTCCATGTGTTTGTTGGGGATTTGAGTCCAGAAATTACAACAGAAGATATCAAATCAGCATTTGCC CCCTTTGGTAAAATATCGGATGCCCGGGTAGTTAAAGACATGGCAACTGGAAAATCCAAAGGCTATGGTTTTGTATCTTTTTATAACAAA CTGGATGCAGAAAATGCGATTGTGCATATGGGCGGTCAGTGGTTGGGTGGTCGTCAAATCCGAACCAATTGGGCCACTCGTAAACCACCT GCACCTAAAAGTACACAAGAAAACAACACTAAGCAGTTGAGATTTGAAGATGTAGTAAACCAGTCAAGTCCAAAAAATTGTACTGTGTAC TGTGGAGGAATTGCGTCTGGGTTAACAGATCAGCTTATGAGACAGACATTCTCACCATTTGGACAAATTATGGAAATAAGAGTTTTCCCA GAAAAGGGCTATTCATTTGTCAGATTTTCAACCCATGAAAGTGCAGCCCATGCCATTGTTTCGGTGAACGGTACTACGATTGAAGGACAT GTGGTTAAATGCTATTGGGGTAAAGAATCTCCTGATATGACTAAAAACTTCCAACAGGTTGACTATAGTCAATGGGGCCAATGGAGCCAA GTGTATGGAAACCCACAACAGTATGGACAGTATATGGCAAATGGGTGGCAAGTACCGCCTTATGGAGTATACGGGCAACCATGGAATCAA CAAGGATTTGGAGTAGATCAATCACCTTCTGCTGCTTGGATGGGTGGATTTGGTGCTCAGCCTCCCCAAGGACAAGCTCCTCCCCCTGTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GDE1_ENST00000353258_chr16_19528336_-_TIAL1_ENST00000369093_chr10_121347760_-_2743nt GATTGGCTGGGCGGCCGACTCCCTCTCTGGATGTGTCTGCTGCCGCCATTGTGCGGCGCTGGTCCCCTCAGAGGGTTCCTGCTGCTGCCG GTGCCTTGGACCCTCCCCCTCGCTTCTCGTTCTACTGCCCCAGGAGCCCGGCGGGTCCGGGACTCCCGTCCGTGCCGGTGCGGGCGCCGG CATGTGGCTGTGGGAGGACCAGGGCGGCCTCCTGGGCCCTTTCTCCTTCCTGCTGCTAGTGCTGCTGCTGGTGACGCGGAGCCCGGTCAA TGCCTGCCTCCTCACCGGCAGCCTCTTCGTTCTACTGCGCGTCTTCAGCTTTGAGCCGGTGCCCTCTTGCAGGGCCCTGCAGGTGCTCAA GCCCCGGGACCGCATTTCTGCCATCGCCCACCGTGGCGGCAGCCACGACGCGCCCGAGAACACGCTGGCGGCCATTCGGCAGGCAGCTAA GAATGGAGCAACAGGCGTGGAGTTGGACATTGAGTTTACTTCTGACGGGATTCCTGTCTTAATGCACGATAACACAGTAGATAGGACGAC TGATGGGACTGGGCGATTGTGTGATTTGACATTTGAACAAATTAGGAAGCTGAATCCTGCAGCAAACCACAGACTCAGATACGTAGGTAA CCTTTCCAGAGATGTGACAGAAGTCCTTATACTTCAGTTGTTCAGTCAGATTGGACCCTGTAAAAGCTGTAAAATGATAACAGAGCAACC CGATAGCAGAAGGGTCAACTCTTCTGTTGGATTTTCTGTTTTGCAGCATACAAGCAATGACCCATATTGCTTTGTGGAATTTTATGAACA CAGAGATGCAGCTGCTGCATTAGCTGCTATGAATGGGAGAAAAATTTTGGGAAAGGAGGTCAAAGTAAACTGGGCAACCACACCAAGTAG CCAGAAAAAAGATACTTCCAATCACTTCCATGTGTTTGTTGGGGATTTGAGTCCAGAAATTACAACAGAAGATATCAAATCAGCATTTGC CCCCTTTGGTAAAATATCGGATGCCCGGGTAGTTAAAGACATGGCAACTGGAAAATCCAAAGGCTATGGTTTTGTATCTTTTTATAACAA ACTGGATGCAGAAAATGCGATTGTGCATATGGGCGGTCAGTGGTTGGGTGGTCGTCAAATCCGAACCAATTGGGCCACTCGTAAACCACC TGCACCTAAAAGTACACAAGAAAACAACACTAAGCAGTTGAGATTTGAAGATGTAGTAAACCAGTCAAGTCCAAAAAATTGTACTGTGTA CTGTGGAGGAATTGCGTCTGGGTTAACAGATCAGCTTATGAGACAGACATTCTCACCATTTGGACAAATTATGGAAATAAGAGTTTTCCC AGAAAAGGGCTATTCATTTGTCAGATTTTCAACCCATGAAAGTGCAGCCCATGCCATTGTTTCGGTGAACGGTACTACGATTGAAGGACA TGTGGTTAAATGCTATTGGGGTAAAGAATCTCCTGATATGACTAAAAACTTCCAACAGGTTGACTATAGTCAATGGGGCCAATGGAGCCA AGTGTATGGAAACCCACAACAGTATGGACAGTATATGGCAAATGGGTGGCAAGTACCGCCTTATGGAGTATACGGGCAACCATGGAATCA ACAAGGATTTGGAGTAGATCAATCACCTTCTGCTGCTTGGATGGGTGGATTTGGTGCTCAGCCTCCCCAAGGACAAGCTCCTCCCCCTGT AATACCTCCTCCTAACCAAGCCGGATATGGTATGGCAAGTTACCAAACACAGTGAGCCGGGACTCTAAAAAAAAATTGTAATTCATGATA GGCTTCGATTTCCTGTGACACTCTGAAGACATGAAAGTAGACATCGGAAAATGAAAATATTTATTTTAAAAATTGAAATGTTTGGAACCT TTAGCACAGATTTGCTTTGGTGAAGGACACGTGTCTTCTAGTTCTGCCTTTTTAAGTTTTTGTTCATGATGGATATGAACATGATTTTTC TTTATGTACAAAAACTAAAATAAAGTCAATAAAGACAATTCTGACTACAAATTTTGATATAATAGGAAAAATGGCTAATACATTTTGATT CTTAGATACTATTCCATTTTTATCTTGCTGTTCAGTATTTTAACTCACTGTGTTTTTAAAAGAGCAAAAAAGGGAGGATCGTGAAAACCT GGGAATCACATATAAGTTCATCCTGAATCCTGATACTCCCCTCCCCTTCCCTGAGGTGGACCACATTTGAAGTCAGCAGAGAAAAAGTGT GATATTCAGAAGAAATGCGTGATTTTGGAGTCGCTTTGGAGGAAATATTTTCTTTCTCTATGCCTAAAGAAACTGAAGCCAGACTGAAGT TTTGCACCCTAAAAAAGGAACAGCATTGTTTGAGTTACTTGAGCAAATGTTGGTGGTCCACGTTAAGACATATTTTTAAAACTTCCAAAA GTGTCGATTATTAAAATTGTAGTATTTTACATTTCATTTTGGGGGGAAATCCAAGTATGGTGTTTGTATTGAAGTCAGACAGTCATACTT GTGCTTTTACATGAAGTTTAAATGATACATATTGTAAATATTCAATAACTACAGTGTTTAAAAAGCATGCTTCAACATAGAAGTAGCAGC AATGTAATTATTTGAAGTAACACTTAACACACTCCGCTGCATTGAATGCAGTGGATTGATCAGAATGTTAAGACTGACATTTCCAAGGTT |
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FusionGenePPI for GDE1_TIAL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GDE1 | RGS16, RGS2, CLGN, ATAD3C, SLC4A7, REEP5, FAM84B, GAPDHS, PLSCR1, ATL3, TMEM109, PROCR, BRI3BP, CXorf58, HNRNPA1, CDK14, DAZAP2, GAP43 | TIAL1 | CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SCAMP3, MRPS28, THY1, ACAA2, VDAC1, SCO2, SBDS, MRPL53, ALDH5A1, GNB2L1, UBE2D2, SOD1, SF3B4, TOMM40, MBNL1, UFM1, SARNP, FN1, VCAM1, ITGA4, GADD45A, MAPK1, SOX2, RPA1, RPA2, RPA3, CUL7, OBSL1, BMI1, CCDC58, PCBP1, PCBP2, PTRHD1, COTL1, DAZAP1, DUT, PIR, RAB10, RSU1, SRI, SSBP1, XPO1, KIF2A, MAPK3, KBTBD7, PCGF1, NANOG, POU5F1, DZIP3, FAM83H, TRO, SAV1, INA, TRIM25, G3BP1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GDE1_TIAL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GDE1_TIAL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GDE1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | GDE1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | TIAL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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