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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14504

FusionGeneSummary for GCK_FRA10AC1

check button Fusion gene summary
Fusion gene informationFusion gene name: GCK_FRA10AC1
Fusion gene ID: 14504
HgeneTgene
Gene symbol

GCK

FRA10AC1

Gene ID

5871

118924

Gene namemitogen-activated protein kinase kinase kinase kinase 2FRA10A associated CGG repeat 1
SynonymsBL44|GCK|RAB8IPC10orf4|F26C11.1-like|FRA10A
Cytomap

11q13.1

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 2B lymphocyte serine/threonine protein kinaseMAPK/ERK kinase kinase kinase 2MEK kinase kinase 2MEKKK 2Rab8 interacting proteingerminal centre kinase (GC kinase)protein FRA10AC1fragile site 10q23.3fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1rare folic acid-type fragile site, FRA(10)(q23.3), candidate gene 1
Modification date2018052320180519
UniProtAcc

P35557

Q70Z53

Ensembl transtripts involved in fusion geneENST00000403799, ENST00000395796, 
ENST00000345378, ENST00000437084, 
ENST00000476008, 
ENST00000359204, 
ENST00000460752, ENST00000536233, 
ENST00000371430, ENST00000394100, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GCK [Title/Abstract] AND FRA10AC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGCK

GO:0006468

protein phosphorylation

11784851

HgeneGCK

GO:0007257

activation of JUN kinase activity

17584736

HgeneGCK

GO:0035556

intracellular signal transduction

11784851

HgeneGCK

GO:0046330

positive regulation of JNK cascade

17584736


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF885201GCKchr7

44184218

+FRA10AC1chr10

95450597

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000403799ENST00000359204GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000403799ENST00000460752GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000403799ENST00000536233GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000403799ENST00000371430GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000403799ENST00000394100GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000395796ENST00000359204GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000395796ENST00000460752GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000395796ENST00000536233GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000395796ENST00000371430GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000395796ENST00000394100GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000345378ENST00000359204GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000345378ENST00000460752GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000345378ENST00000536233GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000345378ENST00000371430GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000345378ENST00000394100GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000437084ENST00000359204GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000437084ENST00000460752GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000437084ENST00000536233GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000437084ENST00000371430GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000437084ENST00000394100GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000476008ENST00000359204GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000476008ENST00000460752GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000476008ENST00000536233GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000476008ENST00000371430GCKchr7

44184218

+FRA10AC1chr10

95450597

+
intron-intronENST00000476008ENST00000394100GCKchr7

44184218

+FRA10AC1chr10

95450597

+

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FusionProtFeatures for GCK_FRA10AC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GCK

P35557

FRA10AC1

Q70Z53

Catalyzes the initial step in utilization of glucose bythe beta-cell and liver at physiological glucose concentration.Glucokinase has a high Km for glucose, and so it is effective onlywhen glucose is abundant. The role of GCK is to provide G6P forthe synthesis of glycogen. Pancreatic glucokinase plays animportant role in modulating insulin secretion. Hepaticglucokinase helps to facilitate the uptake and conversion ofglucose by acting as an insulin-sensitive determinant of hepaticglucose usage. {ECO:0000269|PubMed:11916951,ECO:0000269|PubMed:15277402, ECO:0000269|PubMed:17082186,ECO:0000269|PubMed:18322640, ECO:0000269|PubMed:19146401,ECO:0000269|PubMed:25015100, ECO:0000269|PubMed:8325892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GCK_FRA10AC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GCK_FRA10AC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GCK_FRA10AC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GCK_FRA10AC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGCKC0342277Diabetes mellitus autosomal dominant type II (disorder)13CTD_human;UNIPROT
HgeneGCKC0011860Diabetes Mellitus, Non-Insulin-Dependent4CTD_human;HPO;ORPHANET
HgeneGCKC0011853Diabetes Mellitus, Experimental1CTD_human
HgeneGCKC0020456Hyperglycemia1CTD_human;HPO
HgeneGCKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGCKC1865290Hyperinsulinemic hypoglycemia, familial, 31CTD_human;ORPHANET;UNIPROT
HgeneGCKC3888018Congenital Hyperinsulinism1CTD_human