FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14500

FusionGeneSummary for GCDH_LSP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GCDH_LSP1
Fusion gene ID: 14500
HgeneTgene
Gene symbol

GCDH

LSP1

Gene ID

2639

4046

Gene nameglutaryl-CoA dehydrogenaselymphocyte specific protein 1
SynonymsACAD5|GCDWP34|pp52
Cytomap

19p13.13

11p15.5

Type of geneprotein-codingprotein-coding
Descriptionglutaryl-CoA dehydrogenase, mitochondrialglutaryl-Coenzyme A dehydrogenasetruncated GCDHtruncated glutaryl-CoA dehydrogenaselymphocyte-specific protein 147 kDa actin binding protein52 kDa phosphoproteinF-actin binding and cytoskeleton associated proteinleufactin (leukocyte F-actin binding protein)leukocyte-specific protein 1lymphocyte-specific antigen WP34
Modification date2018052320180527
UniProtAcc

Q92947

P33241

Ensembl transtripts involved in fusion geneENST00000222214, ENST00000591470, 
ENST00000457854, ENST00000422947, 
ENST00000588242, 
ENST00000311604, 
ENST00000381775, ENST00000405957, 
ENST00000406638, ENST00000485341, 
ENST00000599825, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 3=90
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GCDH [Title/Abstract] AND LSP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGCDH

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

25416781


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA714638GCDHchr19

13010345

-LSP1chr11

1913063

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000222214ENST00000311604GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000222214ENST00000381775GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000222214ENST00000405957GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000222214ENST00000406638GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000222214ENST00000485341GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-intronENST00000222214ENST00000599825GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000591470ENST00000311604GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000591470ENST00000381775GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000591470ENST00000405957GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000591470ENST00000406638GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000591470ENST00000485341GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-intronENST00000591470ENST00000599825GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000457854ENST00000311604GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000457854ENST00000381775GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000457854ENST00000405957GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000457854ENST00000406638GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000457854ENST00000485341GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-intronENST00000457854ENST00000599825GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000422947ENST00000311604GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000422947ENST00000381775GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000422947ENST00000405957GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000422947ENST00000406638GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-3UTRENST00000422947ENST00000485341GCDHchr19

13010345

-LSP1chr11

1913063

-
5CDS-intronENST00000422947ENST00000599825GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000588242ENST00000311604GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000588242ENST00000381775GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000588242ENST00000405957GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000588242ENST00000406638GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-3UTRENST00000588242ENST00000485341GCDHchr19

13010345

-LSP1chr11

1913063

-
intron-intronENST00000588242ENST00000599825GCDHchr19

13010345

-LSP1chr11

1913063

-

Top

FusionProtFeatures for GCDH_LSP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GCDH

Q92947

LSP1

P33241

Catalyzes the oxidative decarboxylation of glutaryl-CoAto crotonyl-CoA and CO(2) in the degradative pathway of L-lysine,L-hydroxylysine, and L-tryptophan metabolism. It uses electrontransfer flavoprotein as its electron acceptor. Isoform Short isinactive. {ECO:0000269|PubMed:17176108,ECO:0000269|PubMed:6423663, ECO:0000269|PubMed:8541831}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GCDH_LSP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GCDH_LSP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GCDH_LSP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GCDH_LSP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGCDHC0268595Glutaric aciduria, type 17CTD_human;ORPHANET;UNIPROT
TgeneLSP1C1458155Mammary Neoplasms2CTD_human
TgeneLSP1C0006663Calcinosis1CTD_human
TgeneLSP1C0009324Ulcerative Colitis1CTD_human
TgeneLSP1C0018824Heart valve disease1CTD_human