FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1450

FusionGeneSummary for ALCAM_NRROS

check button Fusion gene summary
Fusion gene informationFusion gene name: ALCAM_NRROS
Fusion gene ID: 1450
HgeneTgene
Gene symbol

ALCAM

NRROS

Gene ID

214

375387

Gene nameactivated leukocyte cell adhesion moleculenegative regulator of reactive oxygen species
SynonymsCD166|MEMDELLP3030|GARPL1|LRRC33|UNQ3030
Cytomap

3q13.11

3q29

Type of geneprotein-codingprotein-coding
DescriptionCD166 antigennegative regulator of reactive oxygen speciesleucine-rich repeat-containing protein 33
Modification date2018051920180523
UniProtAcc

Q13740

Q86YC3

Ensembl transtripts involved in fusion geneENST00000306107, ENST00000472644, 
ENST00000481337, ENST00000486979, 
ENST00000389927, 
ENST00000328557, 
Fusion gene scores* DoF score7 X 6 X 4=1681 X 1 X 1=1
# samples 91
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ALCAM [Title/Abstract] AND NRROS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6339-01AALCAMchr3

105243352

+NRROSchr3

196381398

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000306107ENST00000328557ALCAMchr3

105243352

+NRROSchr3

196381398

+
5CDS-5UTRENST00000472644ENST00000328557ALCAMchr3

105243352

+NRROSchr3

196381398

+
3UTR-5UTRENST00000481337ENST00000328557ALCAMchr3

105243352

+NRROSchr3

196381398

+
5CDS-5UTRENST00000486979ENST00000328557ALCAMchr3

105243352

+NRROSchr3

196381398

+
intron-5UTRENST00000389927ENST00000328557ALCAMchr3

105243352

+NRROSchr3

196381398

+

Top

FusionProtFeatures for ALCAM_NRROS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALCAM

Q13740

NRROS

Q86YC3

Cell adhesion molecule that mediates both heterotypiccell-cell contacts via its interaction with CD6, as well ashomotypic cell-cell contacts (PubMed:7760007, PubMed:15496415,PubMed:15048703, PubMed:16352806, PubMed:23169771,PubMed:24945728). Promotes T-cell activation and proliferation viaits interactions with CD6 (PubMed:15048703, PubMed:16352806,PubMed:24945728). Contributes to the formation and maturation ofthe immunological synapse via its interactions with CD6(PubMed:15294938, PubMed:16352806). Mediates homotypicinteractions with cells that express ALCAM (PubMed:15496415,PubMed:16352806). Required for normal hematopoietic stem cellengraftment in the bone marrow (PubMed:24740813). Mediatesattachment of dendritic cells onto endothelial cells via homotypicinteraction (PubMed:23169771). Inhibits endothelial cell migrationand promotes endothelial tube formation via homotypic interactions(PubMed:15496415, PubMed:23169771). Required for normalorganization of the lymph vessel network. Required for normalhematopoietic stem cell engraftment in the bone marrow. Plays arole in hematopoiesis; required for normal numbers ofhematopoietic stem cells in bone marrow. Promotes in vitroosteoblast proliferation and differentiation (By similarity).Promotes neurite extension, axon growth and axon guidance; axonsgrow preferentially on surfaces that contain ALCAM. Mediatesoutgrowth and pathfinding for retinal ganglion cell axons (Bysimilarity). {ECO:0000250|UniProtKB:P42292,ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938,ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806,ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}. Isoform 3: Inhibits activities of membrane-boundisoforms by competing for the same interaction partners. Inhibitscell attachment via homotypic interactions. Promotes endothelialcell migration. Inhibits endothelial cell tube formation.{ECO:0000269|PubMed:15496415}. Negative regulator of reactive oxygen species (ROS) thatlimits ROS production by phagocytes during inflammatory response,thereby playing a role during host defense. Acts via directinteraction with CYBB/NOX2 monomer that impairs interactionbetween CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2complex (By similarity). May play a critical role in desensitizingTLR signaling through inhibition of Toll-like receptor-mediatedNF-kappa-B activation and cytokine production. {ECO:0000250,ECO:0000269|PubMed:23545260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALCAM_NRROS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ALCAM_NRROS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALCAMCD6, ART3, EGFR, LGALS3, LGALS8, LGALS9, NTRK1, CDC73, LGALS1, PCDH12, APOD, FBXO2NRROSFBXO6, MARK3, MARK2, CNPY3, RTN4RL2, NDST1, CANX, LINGO1, TGFB1, ITPRIP, NDUFA3, EPHB4, ALG9, SDF2L1, POMT1, HSPA5, EXT1, PDF


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALCAM_NRROS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ALCAM_NRROS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALCAMC0024667Animal Mammary Neoplasms1CTD_human
HgeneALCAMC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneNRROSC0023893Liver Cirrhosis, Experimental1CTD_human