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Fusion gene ID: 14464 |
FusionGeneSummary for GATAD2B_TNFSF18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GATAD2B_TNFSF18 | Fusion gene ID: 14464 | Hgene | Tgene | Gene symbol | GATAD2B | TNFSF18 | Gene ID | 57459 | 8995 |
| Gene name | GATA zinc finger domain containing 2B | TNF superfamily member 18 | |
| Synonyms | MRD18|P66beta|p68 | AITRL|GITRL|TL6|TNLG2A|hGITRL | |
| Cytomap | 1q21.3 | 1q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complex | tumor necrosis factor ligand superfamily member 18AITR ligandGITR ligandactivation-inducible TNF-related ligandglucocorticoid-induced TNF-related ligandglucocorticoid-induced TNFR-related protein ligandtumor necrosis factor (ligand) superfamily, mem | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WXI9 | Q9UNG2 | |
| Ensembl transtripts involved in fusion gene | ENST00000368655, | ENST00000239468, ENST00000404377, | |
| Fusion gene scores | * DoF score | 23 X 6 X 12=1656 | 1 X 1 X 1=1 |
| # samples | 25 | 1 | |
| ** MAII score | log2(25/1656*10)=-2.72770267283724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GATAD2B [Title/Abstract] AND TNFSF18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-19-2619-01A | GATAD2B | chr1 | 153895209 | - | TNFSF18 | chr1 | 173013109 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000368655 | ENST00000239468 | GATAD2B | chr1 | 153895209 | - | TNFSF18 | chr1 | 173013109 | - |
| 5UTR-3CDS | ENST00000368655 | ENST00000404377 | GATAD2B | chr1 | 153895209 | - | TNFSF18 | chr1 | 173013109 | - |
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FusionProtFeatures for GATAD2B_TNFSF18 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GATAD2B | TNFSF18 |
| Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2A.Targets MBD3 to discrete loci in the nucleus. May play a role insynapse development. {ECO:0000269|PubMed:12183469,ECO:0000269|PubMed:16415179}. | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower thethreshold for T-cell activation and T-cell proliferation.Important for interactions between activated T-lymphocytes andendothelial cells. Mediates activation of NF-kappa-B. Triggersincreased phosphorylation of STAT1 and up-regulates expression ofVCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion toendothelial cells (PubMed:23892569). Regulates migration ofmonocytes from the splenic reservoir to sites of inflammation (Bysimilarity). {ECO:0000250|UniProtKB:Q7TS55,ECO:0000269|PubMed:17449724, ECO:0000269|PubMed:18040044,ECO:0000269|PubMed:23892569}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GATAD2B_TNFSF18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GATAD2B_TNFSF18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GATAD2B | MBD2, MBD3, RBBP7, RBBP4, MTA2, HDAC1, HDAC2, FOXP1, FOXP2, HIST2H2AC, HIST2H2BE, HIST1H3A, HIST1H4A, PARK7, CHD4, SOX2, MTA1, NDUFA2, NDUFA7, NOTCH1, MTA3, SMAD2, ZBTB1, PRKAB2, GOLGA2, TRIM27, TRAF1, CALCOCO2, TEX11, RPGRIP1, CEP70, USHBP1, BRCA1, SUZ12, EED, RNF2, SUMO2, SIRT6, ZNF219, PHF20L1, CHD3, CHD5, KPNA5, CDK2AP1, ZBTB33, MBD3L1, ZBTB46, NTRK1, GATAD2A, RBPMS, HIST1H3E, KPNA1, TCF20, HMG20A, ZMYND8, NFATC1, FOXC1, FOXG1, FOXJ2, FOXQ1, FOXS1, NFATC2, CPNE5, ZBED1, TXNIP, MAGEE1, FAM219A, L3MBTL2, QPRT, TCF19, IKZF1, IKZF3, CROT, CDC16, PSME3, NCAPH2, MTNR1A, TRIM25, UHRF2, ZNF827 | TNFSF18 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GATAD2B_TNFSF18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GATAD2B_TNFSF18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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