FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14451

FusionGeneSummary for GATAD2B_GATAD2B

check button Fusion gene summary
Fusion gene informationFusion gene name: GATAD2B_GATAD2B
Fusion gene ID: 14451
HgeneTgene
Gene symbol

GATAD2B

GATAD2B

Gene ID

57459

57459

Gene nameGATA zinc finger domain containing 2BGATA zinc finger domain containing 2B
SynonymsMRD18|P66beta|p68MRD18|P66beta|p68
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complextranscriptional repressor p66-betaGATA zinc finger domain-containing protein 2Btranscription repressor p66 beta component of the MeCP1 complex
Modification date2018052320180523
UniProtAcc

Q8WXI9

Q8WXI9

Ensembl transtripts involved in fusion geneENST00000368655, ENST00000368655, 
Fusion gene scores* DoF score23 X 6 X 12=16567 X 6 X 3=126
# samples 257
** MAII scorelog2(25/1656*10)=-2.72770267283724
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GATAD2B [Title/Abstract] AND GATAD2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW073861GATAD2Bchr1

153779245

+GATAD2Bchr1

153777758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000368655ENST00000368655GATAD2Bchr1

153779245

+GATAD2Bchr1

153777758

+

Top

FusionProtFeatures for GATAD2B_GATAD2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GATAD2B

Q8WXI9

GATAD2B

Q8WXI9

Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2A.Targets MBD3 to discrete loci in the nucleus. May play a role insynapse development. {ECO:0000269|PubMed:12183469,ECO:0000269|PubMed:16415179}. Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2A.Targets MBD3 to discrete loci in the nucleus. May play a role insynapse development. {ECO:0000269|PubMed:12183469,ECO:0000269|PubMed:16415179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GATAD2B_GATAD2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GATAD2B_GATAD2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GATAD2B_GATAD2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GATAD2B_GATAD2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource