FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 14437

FusionGeneSummary for GATAD2A_PRDM2

check button Fusion gene summary
Fusion gene informationFusion gene name: GATAD2A_PRDM2
Fusion gene ID: 14437
HgeneTgene
Gene symbol

GATAD2A

PRDM2

Gene ID

54815

7799

Gene nameGATA zinc finger domain containing 2APR/SET domain 2
Synonymsp66alphaHUMHOXY1|KMT8|KMT8A|MTB-ZF|RIZ|RIZ1|RIZ2
Cytomap

19p13.11

1p36.21

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor p66-alphaGATA zinc finger domain-containing protein 2APR domain zinc finger protein 2GATA-3 binding protein G3BMTE-binding proteinPR domain 2PR domain containing 2, with ZNF domainPR domain-containing protein 2lysine N-methyltransferase 8retinoblastoma protein-binding zinc finger proteinretinoblastom
Modification date2018052320180523
UniProtAcc

Q86YP4

Q13029

Ensembl transtripts involved in fusion geneENST00000252577, ENST00000360315, 
ENST00000537887, ENST00000404158, 
ENST00000358713, ENST00000429563, 
ENST00000473184, 
ENST00000376048, 
ENST00000311066, ENST00000235372, 
ENST00000502727, ENST00000413440, 
ENST00000343137, ENST00000503842, 
ENST00000505823, 
Fusion gene scores* DoF score13 X 8 X 9=9364 X 4 X 3=48
# samples 155
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GATAD2A [Title/Abstract] AND PRDM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469

TgenePRDM2

GO:0045944

positive regulation of transcription by RNA polymerase II

8654390


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP381437GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
ChiTaRS3.1AK000843GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000252577ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000252577ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000360315ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000537887ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000404158ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
3UTR-intronENST00000358713ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000429563ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000376048GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000311066GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000235372GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000502727GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000413440GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000343137GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000503842GATAD2Achr19

19617422

+PRDM2chr1

14100959

+
intron-intronENST00000473184ENST00000505823GATAD2Achr19

19617422

+PRDM2chr1

14100959

+

Top

FusionProtFeatures for GATAD2A_PRDM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GATAD2A

Q86YP4

PRDM2

Q13029

Transcriptional repressor. Enhances MBD2-mediatedrepression. Efficient repression requires the presence of GATAD2B.{ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. S-adenosyl-L-methionine-dependent histonemethyltransferase that specifically methylates 'Lys-9' of histoneH3. May function as a DNA-binding transcription factor. Binds tothe macrophage-specific TPA-responsive element (MTE) of the HMOX1(heme oxygenase 1) gene and may act as a transcriptional activatorof this gene. {ECO:0000269|PubMed:14633678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GATAD2A_PRDM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GATAD2A_PRDM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GATAD2A_PRDM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GATAD2A_PRDM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM2C0005695Bladder Neoplasm1CTD_human
TgenePRDM2C0040136Thyroid Neoplasm1CTD_human
TgenePRDM2C0236733Amphetamine-Related Disorders1CTD_human