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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 14408

FusionGeneSummary for GAS7_ATP8B4

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS7_ATP8B4
Fusion gene ID: 14408
HgeneTgene
Gene symbol

GAS7

ATP8B4

Gene ID

8522

79895

Gene namegrowth arrest specific 7ATPase phospholipid transporting 8B4 (putative)
Synonyms-ATPIM
Cytomap

17p13.1

15q21.2

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 7probable phospholipid-transporting ATPase IMATPase, class I, type 8B, member 4P4-ATPase flippase complex alpha subunit ATP8B4potential phospholipid-transporting ATPase IM
Modification date2018052320180523
UniProtAcc

O60861

Q8TF62

Ensembl transtripts involved in fusion geneENST00000437099, ENST00000323816, 
ENST00000432992, ENST00000540214, 
ENST00000585266, ENST00000580865, 
ENST00000583882, ENST00000542249, 
ENST00000396115, ENST00000579158, 
ENST00000578655, 
ENST00000284509, 
ENST00000559829, ENST00000558959, 
Fusion gene scores* DoF score10 X 7 X 6=4207 X 6 X 5=210
# samples 127
** MAII scorelog2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS7 [Title/Abstract] AND ATP8B4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-SG-A849-01AGAS7chr17

10101525

-ATP8B4chr15

50273491

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000437099ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000437099ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000437099ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000323816ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000323816ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000323816ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
Frame-shiftENST00000432992ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
Frame-shiftENST00000432992ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
5CDS-5UTRENST00000432992ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
5UTR-3CDSENST00000540214ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
5UTR-3CDSENST00000540214ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
5UTR-5UTRENST00000540214ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000585266ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000585266ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000585266ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000580865ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000580865ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000580865ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000583882ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000583882ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000583882ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000542249ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000542249ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000542249ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000396115ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000396115ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000396115ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000579158ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000579158ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000579158ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000578655ENST00000284509GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-3CDSENST00000578655ENST00000559829GAS7chr17

10101525

-ATP8B4chr15

50273491

-
intron-5UTRENST00000578655ENST00000558959GAS7chr17

10101525

-ATP8B4chr15

50273491

-

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FusionProtFeatures for GAS7_ATP8B4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS7

O60861

ATP8B4

Q8TF62

May play a role in promoting maturation andmorphological differentiation of cerebellar neurons. Component of a P4-ATPase flippase complex whichcatalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GAS7_ATP8B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GAS7_ATP8B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GAS7PACSIN1, GAS7, ATXN1L, CREB3L2, HNRNPU, KHDRBS1, SF1, SF3A1, SFPQ, RPLP0, ABI1, CYFIP1, CYFIP2, DIAPH1, FMNL1, WAS, WASF2, APBB1IP, NCKAP1, NCKAP1L, GAPDH, WDYHV1, NCKIPSDATP8B4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GAS7_ATP8B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GAS7_ATP8B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS7C0028754Obesity1CTD_human